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The report targets abnormal fallopian tube pathology linked to serous ovarian neoplasia in at-risk perimenopausal women. A 45-year case with pelvic imaging-detected ovarian mass illustrates tubal origin and the potential for earlier detection, supported by increased tubal secretory cells and STIC evidence.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/high-grade-serous-ovarian-cancer-hgsoc-with-fallopian-tube-involvement/332454/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/high-grade-serous-ovarian-cancer-hgsoc-with-fallopian-tube-involvement/332454.png","ImageObject",300,407,{"name":92,"@type":93},"Theodore","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main clinical focus of the article?","Question",{"text":112,"@type":113},"The article focuses on the association between abnormal fallopian tube pathology and serous ovarian neoplasia in at-risk perimenopausal women, particularly regarding high-grade serous ovarian cancer origin.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What symptoms and diagnostic findings are described in the case?",{"text":117,"@type":113},"The case describes a 45-year-old woman with nonspecific abdominal pain, loss of appetite, and weight loss, where pelvic MRI detected an ovarian mass.",{"name":119,"@type":110,"acceptedAnswer":120},"How does the article explain the potential for prevention or earlier detection?",{"text":121,"@type":113},"It argues that the fallopian tube may be a primary origin for pelvic disease, suggesting earlier detection through imaging such as early CT and annual ultrasound, alongside evidence of tubal secretory cell increase and STIC lesions.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332454,1790115085,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},7971461740886,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","CASE REPORT  \nR J M E  \nRomanian Journal of Morphology & Embryology  \n[http://www.rjme.ro/](http://www.rjme.ro/)  \nHigh-grade serous ovarian cancer (HGSOC) with fallopian tube involvement  \nADINA ELENA TĂNASE1), IUSTINA PETRA SOLOMON-CONDRIUC1,2), RALUCA ANAMARIA MOGOŞ1,2), GABRIEL COSTĂCHESCU1), CRISTINA DAVID1), CĂTĂLIN MIHAI BUZDUGĂ3), DRAGOŞ VIOREL SCRIPCARIU4), CLAUDIA FLORIDA COSTEA5,6), ANDREI IONUŢ CUCU7,8), GABRIEL VALENTIN TĂNASE9),  \nDANIELA MARIA TĂNASE10), DRAGOŞ NEMESCU1), ANA MARIA DUMITRESCU11), ALEXANDRU CĂRĂULEANU1)  \n1) Department of Obstetrics and Gynecology, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania  \n2) Doctoral School, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania  \n3) Department of Endocrinology, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania  \n4) Department of General Surgery, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania  \n5) Department of Ophthalmology, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania  \n6)2nd Ophthalmology Clinic, Prof. Dr. Nicolae Oblu Emergency Clinical Hospital, Iaşi, Romania  \n7) Department of Biomedical Sciences, Faculty of Medicine and Biological Sciences, Ştefan cel Mare University of Suceava, Romania  \n8)2nd Neurosurgery Clinic, Prof. Dr. Nicolae Oblu Emergency Clinical Hospital, Iaşi, Romania  \n9) Department of Anesthesia and Intensive Care, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania  \n10) Department of Internal Medicine, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania  \n11) Department of Anatomy, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania  \nAbstract  \nIntroduction: Literature data present new studies about precancerous lesions of pelvic serous carcinoma that originate from the tubal secretory cells. It has long been thought that ovarian cancer cannot be prevented by prophylactic screening or surgery. In recent years, gynecologistshave adapted to new principles and so, during routine hysterectomies in perimenopausal women for benign uterine pathologies, salpingooophorectomy is performed as a prophylactic approach. Aim: The purpose of our article was to draw attention to the association between abnormal fallopian tube pathology and the presence of serous ovarian neoplasia in perimenopausal women at risk. Case presentation: Wereport the case of a 45-year-old woman who had unspecific symptoms of abdominal pain and loss of appetite and weight. A pelvic magnetic resonance imaging was performed, and an ovarian mass was detected. Our case shows that the fallopian tube can be the primary point of origin for a pelvic disease, therefore prevention is possible with early computed tomography scan and annual ultrasound. The patient presented with a T1c staging post-surgery and her chances of survival could have decreased if she had postponed medical examination longer. We found a significant increase in the absolute number of tubal secretory cells in patients with ovarian neoplasia, which supports the assumption that serous tubal intraepithelial carcinoma lesions are found especially in the serous ovarian type. Conclusions: Our article is a strong suggestion that serous ovarian cancer originates from the fallopian tube and can potentially serve as a sensitive biomarker for early serous carcinogenesis within the fallopian tube.  \nKeywords: high-grade serous ovarian cancer, STIC lesion, fallopian tube.  \n􀀕 Introduction  \nWomen diagnosed with invasive high-grade serous ovarian cancer (HGSOC) have a limited time to undergo surgery and treatment, as their survival rate and prognosis are usually unfavorable. Early detection is the key to improving life quality, as well as their prognosis [1] . Several studies showed modifications in the fallopian tube, referred to as serous tubal intraepithelial lesion or STIL, and early ","cbCais4oCKE4zq3x","https://ap.wps.com/l/cbCais4oCKE4zq3x","pdf",1701360,"English","# Abstract\n## Introduction\n## Case presentation\n## Conclusions","[{\"question\":\"What is the main clinical focus of the article?\",\"answer\":\"The article focuses on the association between abnormal fallopian tube pathology and serous ovarian neoplasia in at-risk perimenopausal women, particularly regarding high-grade serous ovarian cancer origin.\"},{\"question\":\"What symptoms and diagnostic findings are described in the case?\",\"answer\":\"The case describes a 45-year-old woman with nonspecific abdominal pain, loss of appetite, and weight loss, where pelvic MRI detected an ovarian mass.\"},{\"question\":\"How does the article explain the potential for prevention or earlier detection?\",\"answer\":\"It argues that the fallopian tube may be a primary origin for pelvic disease, suggesting earlier detection through imaging such as early CT and annual ultrasound, alongside evidence of tubal secretory cell increase and STIC lesions.\"}]","High-grade serous ovarian cancer (HGSOC) with fallopian tube involvement | PDF",1789998251,13]