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HFOs are automatically detected during slow-wave sleep (0.1–500 Hz; 2048 Hz) and confirmed by manual review. Results show HFOs in all 11 DS participants but not in 5 euploid controls, emerging before AD dementia and LOMEDS diagnoses and suggesting age-related rate increases.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/high-frequency-oscillations-during-sleep-in-down-syndrome/459257/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/high-frequency-oscillations-during-sleep-in-down-syndrome/459257.png","ImageObject",300,407,{"name":92,"@type":93},"Olivia Brown","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What question does the study address about Down syndrome and Alzheimer’s disease?","Question",{"text":112,"@type":113},"The study examines whether high frequency oscillations during sleep occur in Down syndrome and whether they precede symptomatic Alzheimer’s disease dementia and LOMEDS diagnoses.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were high frequency oscillations detected in this research?",{"text":117,"@type":113},"Wideband polysomnography using the international 10-20 system was performed, HFOs were automatically detected during slow-wave sleep, and then reviewed manually.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main findings when comparing Down syndrome cases with euploid controls?",{"text":121,"@type":113},"HFOs were detected in all Down syndrome cases but not in controls, with a mean rate of 7.4±2.0 HFOs/min, and HFOs emerged before AD dementia and LOMEDS.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},459257,1791045718,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":81,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":39,"preview_page_count":4},16904993612988,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","DOI: 10. 1002/alz70856_105985  \nBIOMARKERS  \nPOSTER PRESENTATION  \nBIOMARKERS (NON-NEUROIMAGING)  \nHigh Frequency Oscillations During Sleep in Down Syndrome  \nChristos Panagiotis Lisgaras1, 2  Sandra Giménez3, 4, 5  Maria Carmona-Iragui4, 6, 7 Lucía Maure-Blesa8, 9  Esther M Blessing 10, 11  Juan Fortea6, 12, 13   \nRicardo S. Osorio 11, 14, 15  \n1 New York University Grossman School of Medicine, New York, NY, USA  \n2 Nathan S. Kline Institute for Psychiatric Research, Center for Dementia Research, Orangeburg, NY, USA  \n3 Multidisciplinary Sleep unit. Hospital de la Santa Creu i Sant Pau, Institut d’Investigació Biomèdica Sant Pau (IIB SANT PAU), Barcelona, Spain  \n4Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain  \n5Sant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain  \n6 Barcelona Down Medical Center, Fundació CatalanaSíndrome de Down, Barcelona, Spain  \n7 Center for Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain  \n8 CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain  \n9Sant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau, Institut de Recerca Sant PauUniversitat Autònoma de Barcelona, Barcelona, Spain  \n10 New York University, New York City, NY, USA  \n11 Nathan S. Kline Institute, Orangeburg, NY, USA  \n12Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d’Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina-  \nAbstract  \nBackground: Alzheimer’s disease (AD) dementia has near full penetrance in adults with Down syndrome (DS) and is strongly linked to late-onset myoclonic epilepsy syndrome (LOMEDS). However, promising biomarkers of epileptogenicity, such as high frequency oscillations (HFOs>250Hz), have not been studied. This study is the first to use wideband polysomnography in DS to investigate if HFOs occurred and preceded AD dementia and LOMEDS.  \nMethod: Wideband (0. 1-500Hz, 2048Hz) polysomnography was performed using the international 10-20 system. HFOs were automatically detected during slow-wave sleep, followed by manual review.  \nResult: Eleven individuals with DS and five age-matched euploid controls were studied. HFOs were detected in all DS cases but not controls, with a mean rate of 7.4±2.0HFOs/min. HFOs emerged before AD dementia and LOMEDS diagnoses. A trend toward increased HFO rates with age in DS cases warrants further confirmation. Conclusion: HFOs are promising biomarkers that may predict symptomatic AD dementia in adults with DS.  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2025 The Alzheimer’s Association. Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association.  \nAlzheimer’s Dement. 2025;21(Suppl. 2):e105985.  \n[https://doi.org/10.1002/alz70856_105985](https://doi.org/10.1002/alz70856_105985)  \nwi[leyonlinelibrary.com/journal/alz](leyonlinelibrary.com/journal/alz)  \n1of3  \nBIOMARKERS  \nUniversitat Autònoma de Barcelona, Barcelona, Spain  \n13 Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain  \n14 Center for Sleep and Brain Health, Department of Psychiatry, NYU Langone Health, New York, NY, USA  \n15 NYU Grossman School of Medicine, New York, NY, USA  \nCorrespondence  \nChristos Panagiotis Lisgaras, New York University Grossman School of Medicine, New York, NY, USA. [Email:](Email: Christos.Lisgaras@nki.rfmh.org)[ Christos.Lisgaras@nki.rfmh.org](Email: Christos.Lisgaras@nki.rfmh.org)  \nBIOMARKERS","cbCaic1qaIctFaCi","https://ap.wps.com/l/cbCaic1qaIctFaCi","pdf",643647,"English","# Background\n# Method\n# Results\n# Conclusion","[{\"question\":\"What question does the study address about Down syndrome and Alzheimer’s disease?\",\"answer\":\"The study examines whether high frequency oscillations during sleep occur in Down syndrome and whether they precede symptomatic Alzheimer’s disease dementia and LOMEDS diagnoses.\"},{\"question\":\"How were high frequency oscillations detected in this research?\",\"answer\":\"Wideband polysomnography using the international 10-20 system was performed, HFOs were automatically detected during slow-wave sleep, and then reviewed manually.\"},{\"question\":\"What were the main findings when comparing Down syndrome cases with euploid controls?\",\"answer\":\"HFOs were detected in all Down syndrome cases but not in controls, with a mean rate of 7.4±2.0 HFOs/min, and HFOs emerged before AD dementia and LOMEDS.\"}]","High Frequency Oscillations During Sleep in Down Syndrome | PDF",1790755525]