[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-427694-105":59,"doc-detail-427694-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","heterogeneity-in-aging-exploring-grip-strength-variability-in-population-based-age-sex-cohorts","HETEROGENEITY IN AGING - EXPLORING GRIP STRENGTH VARIABILITY IN POPULATION-BASED AGE-SEX COHORTS","","Heterogeneity in aging, defined as variability in traits linked to chronological age, has been recognized in geriatric medicine but remains sparsely tested. Using grip strength as an objective marker of physical function and frailty, a study of 73,134 UK Biobank adults assessed grip strength variability across age-sex cohorts cross-sectionally and longitudinally. Females showed no cross-sectional differences and no longitudinal change within age groups, whereas males exhibited significant cross-sectional decreases and longitudinal increases. Results indicate sex-specific aging heterogeneity patterns.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/heterogeneity-in-aging-exploring-grip-strength-variability-in-population-based-age-sex-cohorts/427694/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/heterogeneity-in-aging-exploring-grip-strength-variability-in-population-based-age-sex-cohorts/427694.png","ImageObject",300,407,{"name":92,"@type":93},"\tCallum ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-20","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How was grip strength used in this study of aging heterogeneity?","Question",{"text":112,"@type":113},"Grip strength served as an objective measure of physical function and frailty to evaluate variability patterns across cohorts.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What sample and design were used for the analysis?",{"text":117,"@type":113},"The study used adults from the UK Biobank database (n=73,134) and examined patterns cross-sectionally and longitudinally across defined age groups.",{"name":119,"@type":110,"acceptedAnswer":120},"How did females and males differ in grip strength variability with age?",{"text":121,"@type":113},"Females showed no significant cross-sectional differences between successively older age groups and no longitudinal change within age cohorts, while males showed cross-sectional decreases and longitudinal increases.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},427694,1790717609,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":24},137451211410,"https://ap-avatar.wpscdn.com/avatar/2000bb0a9246f588df?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786362646172706240","876 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.2964  \nHETEROGENEITY IN AGING: EXPLORING GRIP STRENGTH VARIABILITY IN POPULATION-BASED AGE-SEX COHORTS  \nRichard Fortinsky1, Katherine Zavez1, Lisa Barry1, George Kuchel2, and Ofer Harel1, 1. University of Connecticut, Farmington, Connecticut, United States, 2. UCONN HEALTH, Farmington, Connecticut, United States  \nHeterogeneity in aging is defined as variability in characteristics associated with chronological age. The concept of increased heterogeneity of health-related characteristics with increasing age has long been recognized as a tenet of geriatric medicine. However, a surprisingly limited amount of research has tested this concept. We used grip strength, an objective measure of physical function and frailty, to explore patterns of grip strength variability in population-based age-sex cohorts cross-sectionally and longitudinally. We constructed a study cohort from the UK Biobank database consisting of adults (52% female) with two measures of grip strength (n = 73,134). Age groups at initial measurement were: 40-44, 45-49, 50-54, 55-59, 60-64, and 65-69.  \nIn females and males separately, we compared: (1) patterns of grip strength variability across successively older age groups atone time point; and (2) changes over time in grip strength variability for individuals within the same age group cohort. Cross-sectional results revealed that, for females, grip strength variability did not differ significantly between pairs of successively older age groups; for males, we found statistically significant decreases in grip strength variability across successively older age groups. Longitudinal results showed that grip strength variability did not change over time within age group cohorts among females. In contrast, grip strength variability increased  \nInnovation in Aging, 2025, Vol. 9, No. S2 877  \nover time within nearly all age group cohorts among males. We conclude that heterogeneity in grip strength with aging operates differently for females and males, and that patterns of heterogeneity for males are strikingly different depending on whether age is explored cross-sectionally or longitudinally.","cbCaitjw1tIBCpK8","https://ap.wps.com/l/cbCaitjw1tIBCpK8","pdf",64193,"English","# Abstract\n## Background and concept\n## Study design and cohort\n## Cross-sectional results by sex\n## Longitudinal results by sex\n## Conclusions","[{\"question\":\"How was grip strength used in this study of aging heterogeneity?\",\"answer\":\"Grip strength served as an objective measure of physical function and frailty to evaluate variability patterns across cohorts.\"},{\"question\":\"What sample and design were used for the analysis?\",\"answer\":\"The study used adults from the UK Biobank database (n=73,134) and examined patterns cross-sectionally and longitudinally across defined age groups.\"},{\"question\":\"How did females and males differ in grip strength variability with age?\",\"answer\":\"Females showed no significant cross-sectional differences between successively older age groups and no longitudinal change within age cohorts, while males showed cross-sectional decreases and longitudinal increases.\"}]","HETEROGENEITY IN AGING - EXPLORING GRIP STRENGTH VARIABILITY IN POPULATION-BASED AGE-SEX COHORTS | PDF",1790644577]