[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-379050-105":59,"doc-detail-379050-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","hesperidin-a-bioflavonoid-in-cancer-therapy-a-review-for-a-mechanism-of-action-through-the-modulation-of-cell-signaling-pathways","Hesperidin, a Bioflavonoid in Cancer Therapy - A Review for a Mechanism of Action through the Modulation of Cell Signaling Pathways","","Cancer remains among the most frequent causes of death worldwide, while standard therapies such as radiation and chemotherapy can produce significant adverse effects. Natural bioactive products are presented as supportive options through regulating oxidative stress, inflammation, and cell signaling. This review focuses on hesperidin, a citrus flavonoid with antioxidant, anti-inflammatory, hepatoprotective and cardio-protective attributes, summarizing its anticancer actions via modulation of apoptosis, cell cycle, angiogenesis, and ERK/MAPK signaling pathways, including potential synergy with anticancer drugs and other natural compounds.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/hesperidin-a-bioflavonoid-in-cancer-therapy-a-review-for-a-mechanism-of-action-through-the-modulation-of-cell-signaling-pathways/379050/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/hesperidin-a-bioflavonoid-in-cancer-therapy-a-review-for-a-mechanism-of-action-through-the-modulation-of-cell-signaling-pathways/379050.png","ImageObject",300,407,{"name":92,"@type":93},"WPS_1786070896","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-26","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is cancer therapy challenging in current medical practice?","Question",{"text":112,"@type":113},"Cancer is a major cause of mortality, and common treatments such as radiation therapy and chemotherapy can lead to various adverse effects and high cost.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What is hesperidin and why is it relevant to cancer treatment?",{"text":117,"@type":113},"Hesperidin is a citrus flavonoid with antioxidant and anti-inflammatory properties, and it is proposed as a promising anticancer alternative through modulation of signaling pathways.",{"name":119,"@type":110,"acceptedAnswer":120},"Which cell signaling processes does the review highlight for hesperidin’s anticancer effects?",{"text":121,"@type":113},"The review describes effects related to apoptosis and cell cycle regulation, angiogenesis, and signaling pathways such as ERK/MAPK, alongside modulation of inflammation and other signal transduction molecules.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},379050,1790359771,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},549768072016,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","molecules   \nReview  \nHesperidin, a Bioflavonoid in Cancer Therapy: A Review for a Mechanism of Action through the Modulation of Cell Signaling Pathways  \nArshad Husain Rahmani, Ali Yousif Babiker and Shehwaz Anwar *  \nCitation: Rahmani, A.H.; Babiker, A.Y.; Anwar, S. Hesperidin, a Bioflavonoid in Cancer Therapy: AReview for a Mechanism of Action through the Modulation of Cell Signaling Pathways. Molecules 2023, 28, 5152. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)molecules28135152  \nAcademic Editors: Sylwia Katarzyna Naliwajko, Michal Tomczyk and Muhammad Ilias  \nReceived: 6 May 2023  \nRevised: 13 June 2023  \nAccepted: 23 June 2023  \nPublished: 30 June 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51542, Saudi Arabia  \n* Correspondence: [shehwazanwar25@gmail.com](shehwazanwar25@gmail.com)  \nAbstract: Cancer represents one of the most frequent causes of death in the world. The current therapeutic options, including radiation therapy and chemotherapy, have various adverse effects on patients' health. In this vista, the bioactive ingredient of natural products plays a vital role in disease management via the inhibition and activation of biological processes such as oxidative stress, inflammation, and cell signaling molecules. Although natural products are not a substitute for medicine, they can be effective adjuvants or a type of supporting therapy. Hesperidin, a flavonoid commonly found in citrus fruits, with its potential antioxidant, anti-inflammatory, and hepatoprotective properties, and cardio-preventive factor for disease prevention, is well-known. Furthermore, its anticancer potential has been suggested to be a promising alternative in cancer treatment or management through the modulation of signal transduction pathways, which includes apoptosis, cell cycle, angiogenesis, ERK/MAPK, signal transducer, and the activator of transcription and other cell signaling molecules. Moreover, its role in the synergistic effects with anticancer drugs and other natural compounds has been described properly. The present article describes how hesperidin affects various cancers by modulating the various cell signaling pathways.  \nKeywords: hesperidin; apoptosis; inflammation; signal transduction; cancer therapy  \n1. Introduction  \nCancer represents one of the major causes of mortality around the world. According to cancer statistics, there will soon be a total of 1,918,030 new cases of cancer and 609,360 cancer-related fatalities [1]. The therapeutic choices against cancer include radiation therapy, chemotherapy surgical procedure, and target and gene therapy [2]. The growth and progression of cancer are largely attributed to exogenous variables such as nutrition, the environment, tobacco, chemicals, lifestyle, obesity, diet, and infectious organisms, as well as intrinsic factors such as inherited mutations, genetic predisposition, and immune conditions [3–5]. The current modes of treatment cause adverse effects, in addition to being expensive.  \nNatural products and their bioactive molecules play a significant role in disease management, with lesser adverse effects. Studies conducted in the past have shown that natural substances or their key components can improve health by decreasing oxidative stress and inflammation [6–8], managing diabetes [9], and contributing to the regulation of cell signaling pathways [10–13] .  \nHesperidin is a flavonoid that comes under the flavanone group [14](Figure 1), which is among the most typical and widely distributed groups of plant phenol compounds. Citrus frui","cbCaieOurmJTZoa8","https://ap.wps.com/l/cbCaieOurmJTZoa8","pdf",4116823,28,"English","# Abstract\n# Keywords\n# Introduction\n# Potential Mechanisms of Hesperidin in the Preventative and Therapeutic Management of Cancer\n## Inflammation","[{\"question\":\"Why is cancer therapy challenging in current medical practice?\",\"answer\":\"Cancer is a major cause of mortality, and common treatments such as radiation therapy and chemotherapy can lead to various adverse effects and high cost.\"},{\"question\":\"What is hesperidin and why is it relevant to cancer treatment?\",\"answer\":\"Hesperidin is a citrus flavonoid with antioxidant and anti-inflammatory properties, and it is proposed as a promising anticancer alternative through modulation of signaling pathways.\"},{\"question\":\"Which cell signaling processes does the review highlight for hesperidin’s anticancer effects?\",\"answer\":\"The review describes effects related to apoptosis and cell cycle regulation, angiogenesis, and signaling pathways such as ERK/MAPK, alongside modulation of inflammation and other signal transduction molecules.\"}]","Hesperidin, a Bioflavonoid in Cancer Therapy - A Review for a Mechanism of Action through the Modulation of Cell Signaling Pathways | PDF",1790233886,71]