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This review examines their central role in cancer treatment, focusing on mechanisms of action and therapeutic benefits. Medicinal plants contain bioactive compounds such as flavonoids, alkaloids, terpenoids, and polyphenols that can induce apoptosis, suppress proliferation and cell-cycle progression, and interfere with microtubule formation. The review also covers effects on topoisomerase targets, angiogenesis, signaling pathways, tumor microenvironment, drug resistance, and immune activation. It highlights advantages of herbal anti-cancer drugs, including selective toxicity, reduced chemotherapy side effects, improved tolerance, and possible synergistic effects, while identifying key development challenges.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/herbal-therapies-for-cancer-treatment-a-review-of-phytotherapeutic-efficacy/336737/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/herbal-therapies-for-cancer-treatment-a-review-of-phytotherapeutic-efficacy/336737.png","ImageObject",300,407,{"name":92,"@type":93},"Miles","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Which bioactive compounds in medicinal plants are discussed for anti-cancer activity?","Question",{"text":113,"@type":114},"The review highlights flavonoids, alkaloids, terpenoids, and polyphenols as key bioactive compounds with anticancer properties.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How do phytotherapeutic compounds affect cancer cells according to the review?",{"text":118,"@type":114},"They can induce apoptosis, inhibit cell proliferation and cell-cycle progression, disrupt microtubule formation, target topoisomerases, and modulate angiogenesis and signaling pathways.",{"name":120,"@type":111,"acceptedAnswer":121},"What advantages and remaining challenges for herbal anti-cancer drugs are emphasized?",{"text":122,"@type":114},"Herbal therapies may offer selective toxicity to cancer cells and help alleviate chemotherapy side effects, sometimes with synergistic effects. Challenges include the need for more mechanism-focused research, potential drug interactions, optimal dosing, standardization, improved bioavailability and delivery, and regulatory acceptance.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},336737,1790910656,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},13056703019404,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Biologics: Targets and Therapy Dovepress  \nopen access to scientific and medical research  \n Open Access Full Text Article  \nHerbal Therapies for Cancer Treatment:  \nREVIEW  \nA Review of Phytotherapeutic Efficacy  \nAndrej Jenča 1 , *, David K Mills 2 , *, Hadis Ghasemi 3 , *, Elham Saberian4 , *, Andrej Jenča 1 ,  \nAmir Mohammad Karimi Forood 5 , Adriána Petrášová 1 , Janka Jenčová 1 , Zeinab Jabbari Velisdeh2 , Hadi Zare-Zardini 6 , Meysam Ebrahimifar 7  \n1Klinika of Stomatology and Maxillofacial Surgery Akadémia Košice Bacikova, UPJS LF, Kosice, Slovakia; 2Molecular Science and Nanotechnology, College of Engineering and Science, Louisiana Tech University, Ruston, LA, 71272, USA; 3Department of Chemistry, College of Art and Science, Southern Illinois University Edwardsville, Edwardsville, IL, USA; 4Pavol Jozef Šafárik University, Klinika and Akadémia Košice Bacikova, Kosice, Slovakia; 5Biomedical Engineering Department, University of Connecticut, Storrs, CT, USA; 6Department of Biomedical Engineering, Meybod University, Meybod, Iran; 7Department of Toxicology, Faculty of Pharmacy, Islamic Azad University, Shahreza Branch, Shahreza  \n*These authors contributed equally to this work  \nCorrespondence: Hadi Zare-Zardini; Meysam Ebrahimifar, Email [hzare@meybod.ac.ir](hzare@meybod.ac.ir); [ebrahimifar67@gmail.com](ebrahimifar67@gmail.com)  \n\n| Abstract: Natural products have proven to be promising anti-cancer agents due to their diverse chemical structures and bioactivity. This review examines their central role in cancer treatment, focusing on their mechanisms of action and therapeutic benefits. Medicinal plants contain bioactive compounds, such as flavonoids, alkaloids, terpenoids and polyphenols, which exhibit various anticancer properties. These compounds induce apoptosis, inhibit cell proliferation and cell cycle progression, interfere with microtubule formation, act on topoisomerase targets, inhibit angiogenesis, modulate key signaling pathways, improve the tumor microenvironment, reverse drug resistance and activate immune cells. Herbal anti-cancer drugs offer therapeutic advantages, particularly selective toxicity against cancer cells, reducing the adverse side effects associated with conventional chemotherapy. Recent studies and clinical trials highlight the benefits of herbal medicines in alleviating side effects, improving tolerance to chemotherapy and the occurrence of synergistic effects with conventional treatments. For example, the herbal medicine SH003 was found to be safe and potentially effective in the treatment of solid cancers, while Fucoidan showed anti-inflammatory properties that are beneficial for patients with advanced cancer. The current research landscape on herbal anticancer agents is extensive. Numerous studies and clinical trials are investigating their efficacy, safety and mechanisms of action in various cancers such as lung, prostate, breast and hepatocellular carcinoma. Promising developments include the polypharmacological approach, combination therapies, immunomodulation and the improvement of quality of life. However, there are still challenges in the development and use of natural products as anti-cancer drugs, such as the need for further research into their mechanisms of action, possible drug interactions and optimal dosage. Standardizing herbal extracts, improving bioavailability and delivery, and overcoming regulatory and acceptance hurdles are critical issues that need to be addressed. Nonetheless, the promising anticancer effects and therapeutic benefits of natural products warrant further investigation and development. Multidisciplinary collaboration is essential to advance herbal cancer therapy and integrate these agents into mainstream cancer treatment.\u003Cbr>Keywords: herbal, anti-cancer, chemotherapy, cancer therapy, drug resistance |\n| --- |\n| Introduction\u003Cbr>Cancer is a serious metabolic disease and remains a major cause of mortality despite advances in diagnostic tools, treatment and","cbCaii3JhY1NGVJ4","https://ap.wps.com/l/cbCaii3JhY1NGVJ4","pdf",3486783,27,"English","# Abstract\n# Introduction\n## Background and challenges in cancer treatment\n## Overview of common therapies and treatment selection","[{\"question\":\"Which bioactive compounds in medicinal plants are discussed for anti-cancer activity?\",\"answer\":\"The review highlights flavonoids, alkaloids, terpenoids, and polyphenols as key bioactive compounds with anticancer properties.\"},{\"question\":\"How do phytotherapeutic compounds affect cancer cells according to the review?\",\"answer\":\"They can induce apoptosis, inhibit cell proliferation and cell-cycle progression, disrupt microtubule formation, target topoisomerases, and modulate angiogenesis and signaling pathways.\"},{\"question\":\"What advantages and remaining challenges for herbal anti-cancer drugs are emphasized?\",\"answer\":\"Herbal therapies may offer selective toxicity to cancer cells and help alleviate chemotherapy side effects, sometimes with synergistic effects. Challenges include the need for more mechanism-focused research, potential drug interactions, optimal dosing, standardization, improved bioavailability and delivery, and regulatory acceptance.\"}]","Herbal Therapies for Cancer Treatment - A Review of Phytotherapeutic Efficacy | PDF",1790016410,68]