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Updated evidence is reviewed on disease burden, progression from acute to chronic HBV infection, and reduced immune responses to hepatitis B vaccination. The review also addresses optimal vaccination schedules for CKD, including effects of CKD stages, newer vaccine options for non-responders, revaccination approaches, and durability of vaccine-induced immunity. Additional focus covers HBV transmission risk from HBsAg-positive donors and perioperative management when donor status differs from recipient status.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/hepatitis-b-and-chronic-kidney-disease-bench-to-bedside/406773/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/hepatitis-b-and-chronic-kidney-disease-bench-to-bedside/406773.png","ImageObject",300,407,{"name":92,"@type":93},"Blitz","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why are hepatitis B virus (HBV) and chronic kidney disease (CKD) closely connected?","Question",{"text":113,"@type":114},"CKD is associated with impaired immune status and increased risk of HBV exposure, leading to a complex relationship between the two conditions.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What aspects of hepatitis B vaccination in CKD does the review emphasize?",{"text":118,"@type":114},"It emphasizes serological and cell-mediated immune responses, how CKD stages influence vaccine response, strategies for non-responders, revaccination, and the durability of vaccine-induced immunity.",{"name":120,"@type":111,"acceptedAnswer":121},"How does HBV infection contribute to kidney diseases in people with CKD?",{"text":122,"@type":114},"HBV can predispose CKD populations to various kidney diseases through direct or indirect mechanisms, and renal injury may occur during chronic HBV even without cirrhosis, including in relation to antiviral treatments and cirrhosis.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},406773,1790792500,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":41,"preview_page_count":4},24464137899374,"https://us-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","| W | J | N | World Journal of\u003Cbr>Nephrology |\n| --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Nephrol 2025 December 25; 14(4): 109767  \nDOI: 10.5527/wjn.v14.i4.109767 ISSN 2220-6124 (online)  \nMINIREVIEWS  \nHepatitis B and chronic kidney disease: Bench to bedside  \nSurender Singh, Rajani Singh, Anupma Kaul, Amit Goel  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade B, Grade B, Grade B, Grade C, Grade C Novelty: Grade C, Grade C, Grade C, Grade C, Grade C  \nCreativity or Innovation: Grade C, Grade C, Grade C, Grade C, Grade D  \nScientific Significance: Grade B, Grade B, Grade C, Grade C, Grade C  \nP-Reviewer: Feyissa GD, Assistant Professor, Ethiopia; Hou WM, MD, China; Le KLK, MD, Lecturer, Viet Nam  \nReceived: May 21, 2025  \nRevised: August 17, 2025  \nAccepted: November 27, 2025  \nPublished online: December 25, 2025  \nProcessing time: 216 Days and 15.9 Hours  \nSurender Singh, Rajani Singh, Amit Goel, Department of Hepatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India  \nAnupma Kaul, Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India  \nCorresponding author: Amit Goel, Professor, Department of Hepatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, Uttar Pradesh, India.  \n[agoel.ag@gmail.com](agoel.ag@gmail.com)  \nAbstract  \nChronic kidney disease (CKD) has an intricate relationship with hepatitis B virus (HBV) due to impaired immune status and repeated risk for HBV exposure in people with CKD. Extensive discussion is required on issues related to disease burden, progression of acute HBV infection to chronic infection, impaired immune response to the hepatitis B vaccine, optimal vaccination schedules and strategies, etc. In this review, we attempted to summarize the updated existing knowledge on these topics. In addition, the implication of HBV in the pathogenesis of glomerular disease is also discussed. This review extensively focused on issues related to hepatitis B vaccine induced immune response in CKD patients—serological and cell-mediated immune responses to the vaccine, with particular emphasis on effect of CKD stages on vaccine response, newer types of hepatitis B vaccines for non-responders, revaccination strategies, and the durability of vaccine-induced immunity. We also discussed the literature on risk of HBV transmission following organ from hepatitis B surface antigen (HBsAg)-positive donors, along with perioperative management when the donor is HBsAg-positive but the recipient is HBsAg-negative.  \nKey Words: Hepatitis B; Chronic kidney disease; Vaccination; Dialysis; Renal transplant  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \n WJN  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 25, 2025  Volume 14  Issue 4   \nSingh S et al. Hepatitis B and CKD  \nCore Tip: Hepatitis B virus (HBV) infection is prevalent in chronic kidney disease (CKD) patients, particularly those on hemodialysis. Vaccination against hepatitis B is recommended for all those with CKD. Highly effective oral antiviral drugs with a strong barrier to resistance are available for HBV treatment but they require dose adjustment based on a patients'creatinine clearance. Given the ever-increasing number of patients with CKD and HBV, it is crucial to raise awareness regarding its modes of transmission, prevention strategies, and available treatment modalities.  \nCitation: Singh S, Singh R, Kaul A, Goel A. Hepatitis B and chronic kidney disease: Bench to bedside. World JNephrol 2025; 14(4): 109767  \nURL: [https://www.wjgnet.com/2220-6124/full/v14/i4/109767.htm](https://www.wjgnet.com/2220-6124/ful","cbCaikkdGdx7SWtJ","https://ap.wps.com/l/cbCaikkdGdx7SWtJ","pdf",564444,12,"English","# Abstract\n# Core Tip\n# Introduction\n# Hepatitis B-Related Kidney Disease","[{\"question\":\"Why are hepatitis B virus (HBV) and chronic kidney disease (CKD) closely connected?\",\"answer\":\"CKD is associated with impaired immune status and increased risk of HBV exposure, leading to a complex relationship between the two conditions.\"},{\"question\":\"What aspects of hepatitis B vaccination in CKD does the review emphasize?\",\"answer\":\"It emphasizes serological and cell-mediated immune responses, how CKD stages influence vaccine response, strategies for non-responders, revaccination, and the durability of vaccine-induced immunity.\"},{\"question\":\"How does HBV infection contribute to kidney diseases in people with CKD?\",\"answer\":\"HBV can predispose CKD populations to various kidney diseases through direct or indirect mechanisms, and renal injury may occur during chronic HBV even without cirrhosis, including in relation to antiviral treatments and cirrhosis.\"}]","Hepatitis B and chronic kidney disease: Bench to bedside | PDF",1790567759]