[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-452709-105":59,"doc-detail-452709-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","hepatic-lenticular-degeneration-with-renal-tumors-a-case-series","Hepatic Lenticular Degeneration With Renal Tumors - A Case Series","","This article presents a case series of hepatic lenticular degeneration (Wilson's disease) complicated by renal tumors, describing patient clinical manifestations, diagnostic workflows, treatment strategies, pathological findings, and outcomes. The cases suggest early onset disease, multiple and complex tumor pathological types, and a comparatively poor prognosis. Analysis of these presentations aims to clarify a rare multisystem combination and support evidence-based clinical diagnosis and management.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/hepatic-lenticular-degeneration-with-renal-tumors-a-case-series/452709/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/hepatic-lenticular-degeneration-with-renal-tumors-a-case-series/452709.png","ImageObject",300,407,{"name":92,"@type":93},"ahduag","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What condition links hepatic lenticular degeneration and renal tumors in this case series?","Question",{"text":112,"@type":113},"Hepatic lenticular degeneration is described as Wilson's disease, complicated by renal tumors in the reported patients.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What key clinical features do the authors emphasize across the cases?",{"text":117,"@type":113},"The cases highlight early onset, atypical imaging manifestations, and complex pathological subtypes with high malignancy.",{"name":119,"@type":110,"acceptedAnswer":120},"How is copper metabolism discussed in relation to Wilson's disease and organ damage?",{"text":121,"@type":113},"Copper homeostasis is said to be maintained by biliary excretion, and excessive copper accumulation is described as causing cytotoxicity and multisystem harm, including hepatic and neurological/psychiatric effects.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},452709,1791113298,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},3985747870414,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Clinical Case Reports  \nCASE SERIES  OPEN ACCESS   \nHepatic Lenticular Degeneration With Renal Tumors: A Case Series  \nHaibing Xiao1,2,3  | Mintian Fei1,2,3 | Haoqiang Shi1,2,3 | Xinfeng Ma4 | Qili Xu1,2,3 | Yu Gao1,2,3 | Cheng Yang1,2,3 | Yu Yin5 | Jun Zhou1,2,3 | Chaozhao Liang1,2,3  \n1Department of Urology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, People's Republic of  \nChina | 2Institute of Urology, Anhui Medical University, Hefei, Anhui, People's Republic of China | 3Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, Anhui, People's Republic of China | 4Affiliated Hospital of Institute of Neurology, Anhui University of Traditional Chinese Medicine, Hefei, Anhui, People's Republic of China | 5Department of Pathology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China  \nCorrespondence: Yu Yin ([yinyu@ahmu.edu.cn](yinyu@ahmu.edu.cn)) | Jun Zhou ([zhoujun@ahmu.edu.cn](zhoujun@ahmu.edu.cn)) | Chaozhao Liang ([liang_chaozhao@ahmu.edu.cn](liang_chaozhao@ahmu.edu.cn))  \nReceived: 13 October 2024 | Revised: 12 September 2025 | Accepted: 20 September 2025  \nKeywords: case report | copper metabolism | renal cancer | Wilson's disease  \n\n| ABSTRACT\u003Cbr>This article presents a series of cases involving hepatic lenticular degeneration (Wilson's disease) complicated by renal tumors. It details the clinical manifestations, diagnostic procedures, treatment strategies, pathological features and outcomes of these patients. We found that this type of patient has an early-onset disease, complex tumor pathological types, and may have a relatively poor prognosis. Through the analysis of these cases, we aim to enhance the understanding of this complex condition and provide valuable references for clinical practice. |  |\n| --- | --- |\n| 1 | Introduction | into the secretory pathway, where it is incorporated into apoceruloplasmin to synthesize functional ceruloplasmin and |\n| Copper (Cu), an important element, serves as a vital catalytic | excreted into bile. Wilson's illness is caused by the buildup of |\n| cofactor in several biological processes, including mitochon- | copper in afflicted tissues [4] . The excessive buildup of copper |\n| drial respiration, antioxidant defense, and the synthesis of | in several organs might result in multisystem harm. These may |\n| bio-compounds. Significantly, the intracellular concentration | result in hepatic, neurological, and psychiatric symptoms. Renal |\n| of Cu is maintained within a rather limited range. An incre- | impairment may manifest at any stage of withdrawal delirium |\n| mental increase in Cu may lead to cytotoxicity and may lead | [5], however, the correlation between WD and renal tumors has |\n| to cell death. Therefore, the absorption, transportation, and excretion of Cu are rigorously controlled [1, 2] . Copper homeo- | not been significantly reported. |\n| stasis is maintained exclusively via biliary excretion, as normal | Renal cell carcinoma (RCC) constitutes approximately 5% of |\n| food intake and absorption are usually above the metabolic re- | adult cancers, with an anticipated 431,288 new cases and 179,368 |\n| quirement. Copper builds up in organs including the liver and | fatalities in 2020, highlighting geographic heterogeneity across |\n| brain in Wilson's disease (WD), a hereditary condition caused | 20 global areas [6]. Clear cell renal cell carcinoma (ccRCC) is the |\n| by improper biliary excretion [3] . It is caused by mutations in | most common subtype of RCC and accounts for approximately |\n| the ATP7B gene on chromosome 13, which encodes a coppertransporting P-type ATPase (ATP7B) located in the trans- | 75%–80% of these tumors [7–10] . |\n| Golgi network of hepatocytes. ATP7B is responsible for the | Renal cancer in WD patients has not been reported till 2023. |\n| transportation of copper fr","cbCaibFIZ9TdIsHU","https://ap.wps.com/l/cbCaibFIZ9TdIsHU","pdf",996047,"English","# Abstract\n# Introduction\n## Copper metabolism in Wilson's disease\n## Renal cell carcinoma and related reports\n# Key Clinical Message\n# Case Report\n## Case 1","[{\"question\":\"What condition links hepatic lenticular degeneration and renal tumors in this case series?\",\"answer\":\"Hepatic lenticular degeneration is described as Wilson's disease, complicated by renal tumors in the reported patients.\"},{\"question\":\"What key clinical features do the authors emphasize across the cases?\",\"answer\":\"The cases highlight early onset, atypical imaging manifestations, and complex pathological subtypes with high malignancy.\"},{\"question\":\"How is copper metabolism discussed in relation to Wilson's disease and organ damage?\",\"answer\":\"Copper homeostasis is said to be maintained by biliary excretion, and excessive copper accumulation is described as causing cytotoxicity and multisystem harm, including hepatic and neurological/psychiatric effects.\"}]","Hepatic Lenticular Degeneration With Renal Tumors - A Case Series | PDF",1790737602,18]