[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-detail-431935-en":59,"doc-seo-431935-105":81},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":5,"data":60},{"doc_id":61,"user_id":62,"nickname":63,"user_avatar":64,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":66,"doc_content":67,"file_id":68,"file_url":69,"file_type":70,"file_size":71,"view_count":72,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":73,"language_code":74,"site_id":75,"html_lang":74,"table_of_contents":76,"faqs":77,"seo_title":78,"seo_description":66,"update_tm":79,"read_time":80,"preview_page_count":4},431935,3985747874027,"iuabcfuw","https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Hemoglobin-SC-Algorithm - Clinical Screening Protocol","This document outlines the clinical algorithmic workflow for evaluating Hemoglobin SC (HbS/C) screening results within a newborn screening context. It provides a structured diagnostic pathway, starting from the initial FSC (Hemoglobin Sickle Cell) findings, proceeding through confirmatory tests such as CBC, capillary zone electrophoresis, IEF, or HPLC, and concluding with genetic counseling recommendations. The resource serves as a professional guideline for medical geneticists and clinicians to facilitate consistent, high-quality diagnostic processes for hemoglobinopathies. It emphasizes the necessity of professional judgment in interpreting results, differentiating between confirmed hemoglobinopathies and false-positive cases. The inclusion of molecular genetic testing options highlights the advanced diagnostic approach for definitive identification of hemoglobin traits, supporting comprehensive patient care and genetic education in accordance with standards set by the American College of Medical Genetics and Genomics.","# FSC:Hemoglobin SIC Screening Result\n\nKey  \nunshaded ovals.  \nHgb=hemoglobin level  \n·Diagnostic outcomes are shown in boxes.  \nHPLC=high performance liquid chromatography  \n·Dashed line reflects an optional test.EF=isoelectric focusingMCV=mean corpuscular volume  \nThis practice resource is designed primarily as an educational resource for medical geneticists and other clinicians to help them provide quality medical services.Adherence to this practice resource is completely voluntary and does notnecessarily assure a successful medical outcome.This practice resource should not be considered inclusive of all proper procedures and tests or exclusive of other procedures and tests that are reasonably directed to obtaining thesameresults.In determining the propriety of any specific procedure or test,the clinician should apply his or her own professional judgmentto the specific clinical circumstances presented by the individual patient or specime.Clinicians areencouraged to document the reasons for the use of a particular procedure or test,whether or not it is in conformance with this practice resource.Clinicians also are advised to take notic of the date this practice resource was adopted,andto consider other medical and scientific information that becomes available after that date.It also would be prudent to consider whether intellectual property interests may restrict the performance of certain tests and other procedures.◎American College of Medical Genetics and Genomics,2023 Content Updated:September 2023(Funded in part through MCHB/HRSA/HHS grant\\#U22MC03957;\\#UH9MC30770;National Coordinating Center for the ReqionalGenetics Networks)","cbCaifkmqIOWZsKN","https://ap.wps.com/l/cbCaifkmqIOWZsKN","pdf",138462,13,"English","en",105,"# Clinical Screening Algorithm\n## Diagnostic Workflow\n## Professional Clinical Guidelines","[{\"question\":\"What initial steps should be taken following an abnormal FSC screening result?\",\"answer\":\"The protocol recommends consulting with a sickle cell expert and performing follow-up tests including a complete blood count (CBC), red blood cell smear, and advanced hemoglobin analysis via capillary zone electrophoresis, IEF, or HPLC.\"},{\"question\":\"What is the clinical significance of a HbA result in this algorithm?\",\"answer\":\"If the secondary testing results indicate HbA and are not consistent with a hemoglobinopathy, the initial newborn screening result is considered a false positive, and this should be reported to the appropriate screening program.\"},{\"question\":\"When is molecular genetic testing indicated?\",\"answer\":\"Molecular genetic testing is identified as an optional, secondary step indicated following the confirmation of HbS/C results to provide further diagnostic clarity prior to referring the patient for genetic counseling.\"}]","Hemoglobin-SC-Algorithm - Clinical Screening Protocol | PDF",1790657265,3,{"code":4,"msg":82,"data":83},"ok",{"site_id":75,"language":74,"slug":84,"title":65,"keywords":85,"description":66,"schema_data":86,"social_meta":139,"head_meta":141,"extra_data":143,"updated_unix":144},"hemoglobin-sc-algorithm-clinical-screening-protocol","",{"@graph":87,"@context":138},[88,101,121],{"@type":89,"itemListElement":90},"BreadcrumbList",[91,95,97,99],{"item":92,"name":93,"@type":94,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":96,"name":9,"@type":94,"position":14},"https://docshare.wps.com/document/",{"item":98,"name":35,"@type":94,"position":80},"https://docshare.wps.com/document/healthcare/",{"item":100,"name":65,"@type":94,"position":19},"https://docshare.wps.com/document/hemoglobin-sc-algorithm-clinical-screening-protocol/431935/",{"url":100,"name":65,"@type":102,"image":103,"author":108,"headline":65,"publisher":110,"fileFormat":113,"inLanguage":74,"description":66,"dateModified":114,"datePublished":115,"encodingFormat":113,"isAccessibleForFree":116,"interactionStatistic":117},"DigitalDocument",{"url":104,"@type":105,"width":106,"height":107},"https://docshare.wps.com/thumbnails/hemoglobin-sc-algorithm-clinical-screening-protocol/431935.png","ImageObject",300,407,{"name":63,"@type":109},"Person",{"url":92,"name":111,"@type":112},"DocShare","Organization","application/pdf","2026-10-31","2026-09-29",true,{"@type":118,"interactionType":119,"userInteractionCount":72},"InteractionCounter",{"@type":120},"ViewAction",{"@type":122,"mainEntity":123},"FAQPage",[124,130,134],{"name":125,"@type":126,"acceptedAnswer":127},"What initial steps should be taken following an abnormal FSC screening result?","Question",{"text":128,"@type":129},"The protocol recommends consulting with a sickle cell expert and performing follow-up tests including a complete blood count (CBC), red blood cell smear, and advanced hemoglobin analysis via capillary zone electrophoresis, IEF, or HPLC.","Answer",{"name":131,"@type":126,"acceptedAnswer":132},"What is the clinical significance of a HbA result in this algorithm?",{"text":133,"@type":129},"If the secondary testing results indicate HbA and are not consistent with a hemoglobinopathy, the initial newborn screening result is considered a false positive, and this should be reported to the appropriate screening program.",{"name":135,"@type":126,"acceptedAnswer":136},"When is molecular genetic testing indicated?",{"text":137,"@type":129},"Molecular genetic testing is identified as an optional, secondary step indicated following the confirmation of HbS/C results to provide further diagnostic clarity prior to referring the patient for genetic counseling.","https://schema.org",{"og:url":100,"og:type":140,"og:title":65,"og:site_name":111,"og:description":66},"article",{"robots":142,"canonical":100},"index,follow",{"doc_id":61,"site_id":75},1790862751]