[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-340865-105":59,"doc-detail-340865-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","hematological-neoplasms-with-eosinophilia-review","Hematological Neoplasms with Eosinophilia - Review","","Eosinophilia represents a complex diagnostic challenge requiring multidisciplinary assessment. Peripheral blood eosinophils normally range from 0.3–5%, with values above 0.5 × 10^9/L indicating eosinophilia and ≥1.5 × 10^9/L defining hypereosinophilia; bone marrow involvement is considered when eosinophils exceed 6% of nucleated cells. Causes include reactive (non-hematologic allergic, drug, infectious, or immunologic) and hematology-associated forms, including reactive/secondary eosinophilopoietic cytokine production or clonal neoplastic processes. This review outlines cytomorphology, immunophenotype, biological activity, and broad differential diagnosis, highlighting diagnostic pitfalls and suspicion markers such as splenomegaly and lymphadenopathy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/hematological-neoplasms-with-eosinophilia-review/340865/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/hematological-neoplasms-with-eosinophilia-review/340865.png","ImageObject",300,407,{"name":92,"@type":93},"Logic","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":56},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How is eosinophilia defined in peripheral blood and bone marrow?","Question",{"text":112,"@type":113},"Peripheral eosinophilia is indicated by counts above 0.5 × 10^9/L; hypereosinophilia is defined at counts ≥1.5 × 10^9/L. In bone marrow aspirate, eosinophilia is considered when eosinophils form more than 6% of total nuclear cells.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What are the most common causes of reactive eosinophilia?",{"text":117,"@type":113},"Reactive eosinophilia most commonly arises from non-hematologic conditions, including allergic diseases, drug reactions, infections, and immunological diseases. Solid tumors can also be non-hematologic neoplastic causes.",{"name":119,"@type":110,"acceptedAnswer":120},"Why can eosinophilia be a guiding sign for certain hematologic malignancies?",{"text":121,"@type":113},"Advances in molecular techniques have defined hematologic malignancies with eosinophilia, including myeloid/lymphoid neoplasms with tyrosine kinase gene fusions. In such cases, accurate diagnosis supports targeted therapy, improving quality of life and survival.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},340865,1790197828,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":56,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1099513958762,"https://ap-avatar.wpscdn.com/avatar/1000023916a998db790?x-image-process=image/resize,m_fixed,w_180,h_180&k=1784791008015729253","cancers   \nReview  \nHematological Neoplasms with Eosinophilia  \nRosario M. Morales-Camacho 1, *, Teresa Caballero-Velázquez 1, Juan José Borrero 2, Ricardo Bernal 1 and Concepción Prats-Martín 1, *  \nCitation: Morales-Camacho, R.M.; Caballero-Velázquez, T.; Borrero, J.J.; Bernal, R.; Prats-Martín, C. Hematological Neoplasms with Eosinophilia. Cancers 2024, 16, 337 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cancers16020337  \nAcademic Editors: Xavier Calvo, Leonor Arenillas and Anna Candoni  \nReceived: 30 November 2023  \nRevised: 5 January 2024  \nAccepted: 10 January 2024  \nPublished: 12 January 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Hematology, Virgen del Rocío University Hospital, Seville Biomedicine Institute (IBiS/CSIC), University of Seville, 41013 Seville, Spain; [ricardobernal1@gmail.com](ricardobernal1@gmail.com) (R.B.)  \n2 Department of Pathology, Virgen del Rocío University Hospital, 41013 Seville, Spain; [jborreromt@yahoo.es](jborreromt@yahoo.es)  \n* Correspondence: rosafranco_ 24@yahoo.es (R.M.M.-C.); concha_prats@yahoo.es (C.P.-M.); Tel.: +34-955013261 (R.M.M.-C. & C.P.-M.)  \nSimple Summary: The diagnostic assessment of eosinophilias is complex, requiring a multidisciplinary approach and often involving diagnostic challenges. This work aims for a better understanding of the cytomorphological features, immunophenotype, and biological activity of the eosinophil. Additionally, the concepts of peripheral and bone marrow eosinophilia and their potential causes are reviewed. Finally, the review focuses on the broad differential diagnosis of hematologic diseases that may underlie eosinophilia and how to diagnose them. Among the findings that should raise suspicion of hematologic diseases associated with eosinophilia are the presence of splenomegaly and/or lymphadenopathy or an abnormal blood count. In recent years, with advances in molecular techniques, new hematologic malignancies such as myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions are being defined, where eosinophilia can serve as a guiding sign. In these cases, an accurate diagnosis allows for the use of targeted therapy with an improvement in the quality of life and survival of patients.  \nAbstract: Eosinophils in peripheral blood account for 0.3–5% of leukocytes, which is equivalent to 0.05–0.5 × 109/L. A count above 0 .5 × 109/L is considered to indicate eosinophilia, while a count equal to or above 1 .5 × 109/L is defined as hypereosinophilia. In bone marrow aspirate, eosinophilia is considered when eosinophils make up more than 6% of the total nuclear cells. In daily clinical practice, the most common causes of reactive eosinophilia are non-hematologic, whether they are non-neoplastic (allergic diseases, drugs, infections, or immunological diseases) or neoplastic (solid tumors) . Eosinophilia that is associated with a hematological malignancy may be reactive or secondary to the production of eosinophilopoietic cytokines, and this is mainly seen in lymphoid neoplasms (Hodgkin lymphoma, mature T-cell neoplasms, lymphocytic variant of hypereosinophilic syndrome, and B-acute lymphoblastic leukemia/lymphoma) . Eosinophilia that is associated with a hematological malignancy may also be neoplastic or primary, derived from the malignant clone, usually in myeloid neoplasms or with its origin in stem cells (myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions, acute myeloid leukemia with core binding factor translocations, mastocytosis, myeloproliferative neoplasms, myelodysplastic/myeloproliferative neoplasms, and myelodysplastic neoplasms","cbCaieENY6OeUc5T","https://ap.wps.com/l/cbCaieENY6OeUc5T","pdf",5607678,28,"English","# Review\n## The Eosinophil\n## Eosinophilia Definitions and Causes\n## Diagnostic Challenges and Suspicion Markers\n## Differential Diagnosis of Hematologic Malignancies with Eosinophilia","[{\"question\":\"How is eosinophilia defined in peripheral blood and bone marrow?\",\"answer\":\"Peripheral eosinophilia is indicated by counts above 0.5 × 10^9/L; hypereosinophilia is defined at counts ≥1.5 × 10^9/L. In bone marrow aspirate, eosinophilia is considered when eosinophils form more than 6% of total nuclear cells.\"},{\"question\":\"What are the most common causes of reactive eosinophilia?\",\"answer\":\"Reactive eosinophilia most commonly arises from non-hematologic conditions, including allergic diseases, drug reactions, infections, and immunological diseases. Solid tumors can also be non-hematologic neoplastic causes.\"},{\"question\":\"Why can eosinophilia be a guiding sign for certain hematologic malignancies?\",\"answer\":\"Advances in molecular techniques have defined hematologic malignancies with eosinophilia, including myeloid/lymphoid neoplasms with tyrosine kinase gene fusions. In such cases, accurate diagnosis supports targeted therapy, improving quality of life and survival.\"}]","Hematological Neoplasms with Eosinophilia - Review | PDF",1790039243,71]