[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-376434-105":59,"doc-detail-376434-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","heat-shock-proteins-in-head-and-neck-squamous-cell-carcinoma","Heat Shock Proteins in Head and Neck Squamous Cell Carcinoma","","Heat shock proteins (HSPs) are induced by stressful stimuli such as temperature changes, inflammation, infection, and environmental exposures. Many HSPs are overexpressed in malignancies, where they shape the tumor microenvironment and affect cancer cell behavior and survival. Breast, prostate, colon, and lung cancers have reported clinical trials, yet head and neck squamous cell carcinomas lack comparable evidence. This review summarizes HSP roles in HNSCC physiology and evaluates them as molecular-therapy targets.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/heat-shock-proteins-in-head-and-neck-squamous-cell-carcinoma/376434/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/heat-shock-proteins-in-head-and-neck-squamous-cell-carcinoma/376434.png","ImageObject",300,407,{"name":92,"@type":93},"PakDamar76","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What stimuli induce heat shock proteins (HSPs)?","Question",{"text":112,"@type":113},"HSPs are produced in response to stressful conditions, including high temperature, hypoxia, nutrient deprivation, ischemia, infection, and inflammation.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do HSPs influence tumor biology in general?",{"text":117,"@type":113},"Dysregulated HSP expression is linked to diseases including cancer, and HSPs are implicated in tumor initiation, progression, and drug resistance through effects on cellular protein homeostasis.",{"name":119,"@type":110,"acceptedAnswer":120},"Why are HSPs considered potential targets for therapy in head and neck squamous cell carcinoma?",{"text":121,"@type":113},"The review explains that HSPs can modulate tumor microenvironment and cancer cell survival, and it discusses the possible use of HSP inhibitors as molecular therapy approaches in HNSCC, despite limited clinical trial data.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},376434,1790639660,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962090893057,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Review  \nHeat Shock Proteins in Head and Neck Squamous Cell Carcinoma  \nPiotr Cierpikowski 1, * and Julia Bar 2, *  \n1 Department of Maxillofacial Surgery, The Ludwik Rydygier Specialist Hospital, Osiedle Zlotej Jesieni 1, 31-826 Krakow, Poland  \n2 Department of Immunopathology and Molecular Biology, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland  \n* Correspondence: [cierpikowski@gmail.com](cierpikowski@gmail.com) (P.C.); [julia.bar@umw.edu.pl](julia.bar@umw.edu.pl) (J.B.); Tel.: +48-12-646-83-91 (P.C.);+48-697-770-614 (J.B.)  \nAbstract  \nHeat shock proteins (HSPs) are produced in response to stressful conditions, such as temperature, inflammation, infection, or exposure to environmental factors. HSPs are overexpressed in some malignancies, where they modulate the tumor microenvironment and influence cancer cell behavior and survival. Clinical trials for breast, prostate, colon, and lung cancers exist, but not for head and neck squamous cell carcinomas (HNSCCs) . Nonetheless, clinical studies on HSPs in HNSCC are still lacking. We review the role of HSPs with regard to physiology and as potential targets for molecular therapy in HNSCC.  \nKeywords: heat shock proteins; head and neck cancer; molecular targeted therapy  \nAcademic Editor: Jozsef Dudas  \nReceived: 18 October 2025  \nRevised: 22 November 2025  \nAccepted: 25 November 2025  \nPublished: 28 November 2025  \nCitation: Cierpikowski, P.; Bar, J. Heat Shock Proteins in Head and Neck Squamous Cell Carcinoma. Cells 2025, 14, 1897. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cells14231897  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \n1. Introduction  \nHeat shock proteins (HSPs) are a family of molecular chaperones that play a role in protein synthesis, secretion, folding, stabilization, translocation, and proteolysis [1,2] . Although the precise role of HSPs in tumor biology is unclear, HSPs appear to be involved in carcinogenesis and drug resistance [2–4] .  \nThis paper is a summary of the current knowledge on HSPs (especially HSP27, HSP70, and HSP90) in head and neck squamous cell carcinoma (HNSCC) . We also consider the potential role of HSPs in their pathogenesis and the possible use of HSP inhibitors in therapy.  \n2. The HSP Family: Characteristics and Classification of HSPs  \nHSPs play a regulatory role as chaperones in protein-folding homeostasis and are involved in proliferation, differentiation, apoptosis, and responses to stress [3,5–8] . HSPs are activated by stressors such as high temperature, hypoxia, lack of nutrients, ischemia, infection, and inflammation [2,4] . They prevent protein aggregation by binding to misfolded proteins and helping them refold when the stress subsides [2] . HSPs prevent the accumulation of damaged proteins by regulating the ubiquitin–proteasome system, which is involved in the degradation of aggregated or improperly folded proteins [4] . HSPs constitute 5–10% of all proteins in normal cells and increase in response to stress [4,9] . They range in size from 10 kDa to >100 kDa and are divided into small HSPs [sHSPs—HSP20 and HSP27], HSP40, HSP60, HSP70, and HSP90, and large HSPs [HSP105 and HSP110][4,10,11] .  \nTen sHSPs [HSPB1 to HSPB10] are first responders to cellular stress and do not use ATP [3,4,6,12] . Their α-crystallin domain (ACD) sequence is located near the C-terminus [11] . HSPB1, also called HSP27, is its most prominent member [6] .  \nThe HSP40 family is divided into three subclasses: Type I (DNAJA), Type II (DNAJB), and Type III (DNAJC) [8] . They have a highly conserved J-domain composed of four α-helices. They may interact with HSP70 by stimulating ATPase activity [6,8] . HSP40 ass","cbCaiqXn8Pd1WL7x","https://ap.wps.com/l/cbCaiqXn8Pd1WL7x","pdf",804308,21,"English","# Introduction\n# The HSP Family: Characteristics and Classification of HSPs\n# The Role of HSPs in Cancer","[{\"question\":\"What stimuli induce heat shock proteins (HSPs)?\",\"answer\":\"HSPs are produced in response to stressful conditions, including high temperature, hypoxia, nutrient deprivation, ischemia, infection, and inflammation.\"},{\"question\":\"How do HSPs influence tumor biology in general?\",\"answer\":\"Dysregulated HSP expression is linked to diseases including cancer, and HSPs are implicated in tumor initiation, progression, and drug resistance through effects on cellular protein homeostasis.\"},{\"question\":\"Why are HSPs considered potential targets for therapy in head and neck squamous cell carcinoma?\",\"answer\":\"The review explains that HSPs can modulate tumor microenvironment and cancer cell survival, and it discusses the possible use of HSP inhibitors as molecular therapy approaches in HNSCC, despite limited clinical trial data.\"}]","Heat Shock Proteins in Head and Neck Squamous Cell Carcinoma | PDF",1790219187,53]