[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332431-105":59,"doc-detail-332431-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","heat-shock-proteins-as-hallmarks-of-cancer-insights-from-molecular-mechanisms-to-therapeutic-strategies","Heat shock proteins as hallmarks of cancer - insights from molecular mechanisms to therapeutic strategies","","Heat shock proteins act as essential molecular chaperones that stabilize protein structures, enable repair or degradation of damaged proteins, and maintain proteostasis and cellular function. Research shows that heat shock proteins are frequently overexpressed in cancers and are tightly linked to tumor initiation and progression. This review connects heat shock proteins with hallmarks of cancer and summarizes small-molecule inhibitors targeting them, including combination strategies with dual-target approaches.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/heat-shock-proteins-as-hallmarks-of-cancer-insights-from-molecular-mechanisms-to-therapeutic-strategies/332431/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/heat-shock-proteins-as-hallmarks-of-cancer-insights-from-molecular-mechanisms-to-therapeutic-strategies/332431.png","ImageObject",300,407,{"name":92,"@type":93},"Theodore","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What roles do heat shock proteins play in cells?","Question",{"text":112,"@type":113},"They function as molecular chaperones that stabilize protein structures, support repair or degradation of damaged proteins, and maintain proteostasis and cellular functions.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How are heat shock proteins linked to cancer development?",{"text":117,"@type":113},"Heat shock proteins are highly expressed in cancers and are closely associated with tumorigenesis and progression, influencing multiple cancer hallmarks through signaling pathway modulation.",{"name":119,"@type":110,"acceptedAnswer":120},"What therapeutic strategies does the review emphasize?",{"text":121,"@type":113},"It summarizes small-molecule inhibitors targeting heat shock proteins and discusses combination therapy strategies that pair heat shock proteins with promising dual-target inhibitors.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332431,1790197203,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},7971461740886,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","Zuo etal. Journal of Hematology & Oncology (2024) 17:81 [https://doi.org/10.1186/s13045-024-01601-1](https://doi.org/10.1186/s13045-024-01601-1)  \nJournal of Hematology & Oncology  \n REVIEW Open Access  \nHeat shock proteins as hallmarks of cancer:   insights from molecular mechanisms to therapeutic strategies  \nWei-Fang Zuo1†, Qiwen Pang1†, Xinyu Zhu1†, Qian-QianYang1, Qian Zhao3, Gu He2*, Bo Han1 and Wei Huang1*  \nAbstract  \nHeat shock proteins are essential molecular chaperones that play crucial roles in stabilizing protein structures, facilitating the repair or degradation of damaged proteins, and maintaining proteostasis and cellular functions. Extensive research has demonstrated that heat shock proteins are highly expressed in cancers and closely associated with tumorigenesis and progression. The \"Hallmarks of Cancer\" are the core features of cancer biology that collectively define a series of functional characteristics acquired by cells as they transition from a normal state to a state of tumor growth, including sustained proliferative signaling, evasion of growth suppressors, resistance to cell death, enabled replicative immortality, the induction of angiogenesis, and the activation of invasion and metastasis. The pivotal roles of heat shock proteins in modulating the hallmarks of cancer through the activation or inhibition of various signaling pathways has been well documented. Therefore, this review provides an overview of the roles of heat shock proteins in vital biological processes from the perspective of the hallmarks of cancer and summarizes the small-molecule inhibitors that target heat shock proteins to regulate various cancer hallmarks. Moreover, we further discuss combination therapy strategies involving heat shock proteins and promising dual-target inhibitors to highlight the potential of targeting heat shock proteins for cancer treatment. In summary, this review highlights how targeting heat shock proteins could regulate the hallmarks of cancer, which will provide valuable information to better elucidate and understand the roles of heat shock proteins in oncology and the mechanisms of cancer occurrence and development and aid in the development of more efficacious and less toxic novel anticancer agents.  \nKeywords Cancer, Heat shock protein, Hallmarks of cancer, Target therapy, Combination strategy, Dual inhibitors  \n†Wei-Fang Zuo, Qiwen Pang and Xinyu Zhu have contributed equally to this work  \n*Correspondence: Gu He[hegu@scu.edu.cn](hegu@scu.edu.cn)[ ](hegu@scu.edu.cn)Wei Huang  \n[huangwei@cdutcm.edu.cn](huangwei@cdutcm.edu.cn)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/.)[.](http://creativecommons.org/licenses/by-nc-nd/4.0/.)  \nZuo etal. Journal of Hematology & Oncology (2024) 17:81 Page 2 of 58  \nGraphic abstract  \nBackground  \nProteins are pivotal constituents within living organisms, embodying th","cbCainlLPbSAkJsi","https://ap.wps.com/l/cbCainlLPbSAkJsi","pdf",4153874,58,"English","# Abstract\n# Background\n## Protein folding, marginal stability, and misfolding\n## Cellular protein quality control systems\n## Molecular chaperones and the ubiquitin–proteasome system\n## Heat shock proteins (HSPs) and historical discovery","[{\"question\":\"What roles do heat shock proteins play in cells?\",\"answer\":\"They function as molecular chaperones that stabilize protein structures, support repair or degradation of damaged proteins, and maintain proteostasis and cellular functions.\"},{\"question\":\"How are heat shock proteins linked to cancer development?\",\"answer\":\"Heat shock proteins are highly expressed in cancers and are closely associated with tumorigenesis and progression, influencing multiple cancer hallmarks through signaling pathway modulation.\"},{\"question\":\"What therapeutic strategies does the review emphasize?\",\"answer\":\"It summarizes small-molecule inhibitors targeting heat shock proteins and discusses combination therapy strategies that pair heat shock proteins with promising dual-target inhibitors.\"}]","Heat shock proteins as hallmarks of cancer - insights from molecular mechanisms to therapeutic strategies | PDF",1789998166,146]