[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-458403-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-458403-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","heart-rate-variability-and-intrinsic-autonomic-coupling-in-ehlersdanlos-syndrome","Heart Rate Variability and Intrinsic Autonomic Coupling in Ehlers–Danlos Syndrome","","Study of Ehlers-Danlos syndrome (EDS) addresses connective-tissue disorders with growing recognition of cardiovascular autonomic dysfunction, where systematic physiologic evaluation has remained limited. This cross-sectional work evaluates autonomic function using standardized autonomic testing and short-term heart rate variability (HRV) from a five-minute supine ECG, deriving indices via FFT. Thirty EDS patients are compared with 30 age- and sex-matched controls, and resting heart rate is correlated with HRV to assess intrinsic autonomic coupling.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/heart-rate-variability-and-intrinsic-autonomic-coupling-in-ehlersdanlos-syndrome/458403/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/heart-rate-variability-and-intrinsic-autonomic-coupling-in-ehlersdanlos-syndrome/458403.png","ImageObject",300,407,{"name":42,"@type":43},"นรินทร์","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main objective of this study in Ehlers–Danlos syndrome?","Question",{"text":63,"@type":64},"To characterize cardiovascular autonomic function in EDS using standardized autonomic testing and HRV indices, and to explore intrinsic autonomic coupling by relating resting heart rate to HRV parameters.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were heart rate variability and autonomic function measured?",{"text":68,"@type":64},"Participants underwent short-term HRV analysis from a five-minute supine ECG and standard autonomic testing, including head-up tilt. HRV indices were calculated using Fast Fourier Transform (FFT) algorithms.",{"name":70,"@type":61,"acceptedAnswer":71},"What were the key findings comparing EDS patients with healthy controls?",{"text":72,"@type":64},"EDS patients showed higher resting heart rate and altered HRV markers, including lower parasympathetic time-domain indices and changes in frequency-domain measures. Orthostatic intolerance was more common in the EDS group, and resting heart rate correlated with multiple HRV outcomes.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},458403,1790904645,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":97,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},2336475104957,"https://ap-avatar.wpscdn.com/avatar/22000c4c6bd8a5076e1?x-image-process=image/resize,m_fixed,w_180,h_180&k=1787554080175789136","Review began 11/16/2025  \nReview ended 12/03/2025  \nPublished 12/08/2025  \n© Copyright 2025  \nAlauddin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CCBY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.98693  \nOpen Access Original Article  \nHeart Rate Variability and Intrinsic Autonomic Coupling in Ehlers–Danlos Syndrome  \nWaqas Alauddin 1, Prajakta M. Radke 2 , Nithya Janardhana 3, Ishita Singh 4 , Ayush Sharma 5, Shashwat Arora 6, Brishabh R. Prajesh 1, Rishika Shree 1, Zaki Shaikh 2  \n1. Physiology, Naraina Medical College and Research Centre, Kanpur, IND 2. Physiology, Mahatma Gandhi Mission Medical College, Nerul, IND 3. Medicine, Adichunchanagiri Institute of Medical Sciences, Karnataka, IND 4. Medicine, Lala Lajpat Rai Memorial Medical College, Meerut, IND 5. Medicine, Amar Shaheed Jodha Singh Atayiya Thakur Dariyao Singh Medical College, Fatehpur, IND 6. Medicine, Naraina Medical College and Research Centre, Kanpur, IND  \nCorresponding author: Prajakta M. Radke, [prajaktaradke@gmail.com](prajaktaradke@gmail.com)  \nAbstract  \nBackground  \nEhlers-Danlos syndrome (EDS) encompasses a group of connective tissue disorders often extending beyond musculoskeletal involvement. Emerging evidence indicates a high prevalence of cardiovascular autonomic dysfunction in this population, yet systematic physiologic evaluations remain limited.  \nObjective  \nTo characterize cardiovascular autonomic function in EDS using standardized autonomic testing and heart rate variability (HRV) indices, and to explore intrinsic autonomic coupling by correlating resting heart rate with HRV parameters.  \nMethods  \nThis cross-sectional study included 30 clinically diagnosed patients with EDS and 30 age-and sex-matched healthy controls. Short-term HRV analysis (five-minute supine ECG) and standard autonomic testing, including head-up tilt, were performed under controlled laboratory conditions. HRV indices were derived using Fast Fourier Transform (FFT) algorithms. Group differences were evaluated with independent t-tests, and correlations between resting heart rate and HRV measures were analyzed using Pearson’s correlation.  \nResults  \nCompared with controls, patients with EDS exhibited higher resting heart rate (87.3± 11.6 vs 75.2±9.8 bpm), lower parasympathetic time-domain indices (standard deviation of normal-to-normal intervals or SDNN 35.4±9.7 vs 49.1± 11.4 ms; root mean square of successive differences (RMSSD; 20.7±6.9 vs 31.6±8.8 ms), and altered frequency-domain markers (low frequency (LF) power 671±205 vs 542± 176 ms² ; high frequency (HF) power 174±81 vs 272± 106 ms² ; LF/HF ratio 3.7± 1.3 vs 1.8±0. 7) . Orthostatic intolerance was observed in 16 (53 .3%) of the patients with EDS versus three (10%) of the controls. Correlation analysis revealed that in EDS, resting HR correlated negatively with SDNN (r= -0.45, p=0 .01), RMSSD (r= -0.52, p\u003C0 .01), and HF power (r= -0.39, p=0 .03), while showing a positive correlation with LF/HF ratio (r=0 .58, p\u003C0 .001) .  \nConclusion  \nPatients with EDS had autonomic dysregulation, with sympathetic predominance and diminished vagal modulation. The intrinsic coupling between resting heart rate and HRV indices suggests impaired cardiovascular autonomic integration. HRV profiling is a valuable noninvasive biomarker for early identification and longitudinal monitoring of autonomic dysfunction in EDS, potentially enhancing disease characterization and guiding individualized therapeutic strategies.  \nCategories: Neurology, Cardiology, Internal Medicine  \nKeywords: autonomic nervous system, cardiovascular autonomic dysfunction, dysautonomia, ehlers-danlos syndrome, heart rate variability, orthostatic intolerance, parasympathetic nervous system, parasympathetic tone, postural tachycardia syndrome, sympathetic nervous system  \nIntroduction  \nE","cbCaiqPJSsE4p0R1","https://ap.wps.com/l/cbCaiqPJSsE4p0R1","pdf",132596,"English","# Abstract\n## Background\n## Objective\n## Methods\n## Results\n## Conclusion\n# Introduction\n## EDS and autonomic dysfunction\n## HRV and autonomic balance","[{\"question\":\"What is the main objective of this study in Ehlers–Danlos syndrome?\",\"answer\":\"To characterize cardiovascular autonomic function in EDS using standardized autonomic testing and HRV indices, and to explore intrinsic autonomic coupling by relating resting heart rate to HRV parameters.\"},{\"question\":\"How were heart rate variability and autonomic function measured?\",\"answer\":\"Participants underwent short-term HRV analysis from a five-minute supine ECG and standard autonomic testing, including head-up tilt. HRV indices were calculated using Fast Fourier Transform (FFT) algorithms.\"},{\"question\":\"What were the key findings comparing EDS patients with healthy controls?\",\"answer\":\"EDS patients showed higher resting heart rate and altered HRV markers, including lower parasympathetic time-domain indices and changes in frequency-domain measures. Orthostatic intolerance was more common in the EDS group, and resting heart rate correlated with multiple HRV outcomes.\"}]","Heart Rate Variability and Intrinsic Autonomic Coupling in Ehlers–Danlos Syndrome | PDF",1790752864,13]