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This study evaluates how auditory and speech-perception performance relates to neuroimaging neurodegeneration (N), amyloid (A), and tau (T) measures to support early AD detection. Method: 121 participants underwent auditory testing and MRI/amyloid/tau PET quantification, using ANCOVA and partial Pearson correlations controlling for age, sex, and intracranial volume.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/hearing-and-speech-perception-are-associated-with-atn-biomarkers-of-alzheimers-disease-poster-presentation/456214/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/hearing-and-speech-perception-are-associated-with-atn-biomarkers-of-alzheimers-disease-poster-presentation/456214.png","ImageObject",300,407,{"name":92,"@type":93},"Elsa","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-07","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the study’s main goal?","Question",{"text":112,"@type":113},"To determine whether auditory and speech-perception performance is associated with Alzheimer’s disease A/T/N biomarkers derived from neuroimaging.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were auditory abilities and biomarkers measured?",{"text":117,"@type":113},"Auditory tests included CUNY sentences, Speech-in-Noise (QuickSiN), and Letter Number Sequencing (LNS). Neuroimaging included cortical volume from MRI (N), cortical Centiloid from amyloid PET (A), and meta-temporal tau SUVR from tau PET (T).",{"name":119,"@type":110,"acceptedAnswer":120},"Which biomarkers showed significant associations with speech or auditory measures?",{"text":121,"@type":113},"Cortical amyloid correlated with SNR loss and multiple CUNY subscores, while meta-temporal tau SUVR associated with several CUNY measures and LNS raw scores, with no association reported for SNR measures.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},456214,1790790440,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":24},137455077381,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","DOI: 10. 1002/alz70856_107173  \nBIOMARKERS  \nPOSTER PRESENTATION  \nBIOMARKERS (NON-NEUROIMAGING)  \nHearing and Speech Perception are Associated with A/T/N Biomarkers of Alzheimer’s Disease  \nElodie Foster 1  Carolyn Herbert2  Aaron Vosmeier 1  Savannah Hottle 1  Liana G. Apostolova 1, 3  Jared R. Brosch 1  David G. Clark 1, 3  Martin R Farlow 1 Sunu Mathew 1  Fredrick Unverzagt 1  Sophia Wang 1  Sujuan Gao4  Charles W Yates2  David Pisoni2  Andrew J. Saykin 1, 5  Shannon L Risacher1, 6  \n1 Indiana Alzheimer’s Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA  \n2 Department of Otolaryngology-Head & Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA  \n3 Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA  \n4 Indiana Alzheimer’s Disease Research Center, Indianapolis, IN, USA  \n5 Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA  \n6 Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA  \nCorrespondence  \nShannon L Risacher, Indiana Alzheimer’s Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA. [Email:](Email: srisache@iu.edu)[ srisache@iu.edu](Email: srisache@iu.edu)  \nAbstract  \nBackground: Hearing loss is linked to dementia, yet its relationship with Alzheimer’s disease (AD) biomarkers remains unclear. This study examines associations between performance on auditory and speech perception measures with neuroimaging measures of neurodegeneration (N; cortical volume), amyloid (A), and tau (T) to aid early AD detection.  \nMethod: 121 participants from the Indiana Alzheimer’s Disease Research Center underwent auditory testing and neuroimaging. Auditory assessments included CUNY sentences, Speech-in-Noise (QuickSiN), and Letter Number Sequencing (LNS). Neuroimaging measures included MRI-based cortical volume extracted with Freesurfer v6 (N), cortical Centiloid value from amyloid PET (A), and bilateral mean meta-temporal tau standardized uptake value ratio from tau PET (T). A one-way ANCOVA was used to compare differences in auditory tests between diagnostic groups, while partial Pearson correlations were used to assess associations of auditory tests with A/T/N biomarkers, covaried for age, sex, and total intracranial volume (N only).  \nResult: The sample (age=71.90±6. 6; 63. 9% female) included 49 cognitively normal older adults, 40 with subjective cognitive decline, 23 with mild cognitive impairment (MCI) due to AD, 7 with MCI due to other conditions, and 2 with AD. Significant diagnostic differences were observed in SNR loss on QuickSiN (p = .006) and CUNY subtests, including AV words(p \u003C.001), AV sentences(p = .037), andA words(p = .002). Cortical amyloid correlated with SNR loss (r=.231, p = .045) and CUNY subscores, including auditory (Au) words (r= -. 272, p = .018) and word gain (r= -. 250, p = .031). LNS raw scores correlated with cortical volume (r= -. 311, p = .008). Associations were  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2025 The Alzheimer’s Association. Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association.  \nAlzheimer’s Dement. 2025;21(Suppl. 2):e107173.  \n[https://doi.org/10.1002/alz70856_107173](https://doi.org/10.1002/alz70856_107173)  \nwi[leyonlinelibrary.com/journal/alz](leyonlinelibrary.com/journal/alz)  \n1of2  \nBIOMARKERS  \nfound between cortical volume and CUNY audiovisual (AV) words (r=.254, p = .023), A words (r=.395, p \u003C .001), and sentence gain (r= -. 261, p = .020), but not with SNR loss. Meta-temporal tau SUVR was associated with CUNYA words (r= -. 294, p = .021), A sent (r= -. 276, p = .031), word gain (r=.303, p = .016), and LNS raw scores (r= -. 276, p = .036","cbCaijfrrQ3g1WuS","https://ap.wps.com/l/cbCaijfrrQ3g1WuS","pdf",96473,"English","# Abstract\n## Background\n## Method\n## Result\n## Conclusion","[{\"question\":\"What is the study’s main goal?\",\"answer\":\"To determine whether auditory and speech-perception performance is associated with Alzheimer’s disease A/T/N biomarkers derived from neuroimaging.\"},{\"question\":\"How were auditory abilities and biomarkers measured?\",\"answer\":\"Auditory tests included CUNY sentences, Speech-in-Noise (QuickSiN), and Letter Number Sequencing (LNS). Neuroimaging included cortical volume from MRI (N), cortical Centiloid from amyloid PET (A), and meta-temporal tau SUVR from tau PET (T).\"},{\"question\":\"Which biomarkers showed significant associations with speech or auditory measures?\",\"answer\":\"Cortical amyloid correlated with SNR loss and multiple CUNY subscores, while meta-temporal tau SUVR associated with several CUNY measures and LNS raw scores, with no association reported for SNR measures.\"}]","Hearing and Speech Perception are Associated with A/T/N Biomarkers of Alzheimer’s Disease - Poster Presentation | PDF",1790745353]