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Overall short-term HRQoL was broadly comparable, with age–comorbidity and time–comorbidity interactions indicating less favorable trajectories in older, multimorbid 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ORIGINAL RESEARCH  \nHealth-Related Quality of Life in Patients End-Stage Kidney Disease with Hypertension:  \nHemodialysis Vs Continuous Ambulatory Peritoneal Dialysis Using EQ-5D-5L at a Tertiary Center in Indonesia  \nWening Wulandari 1–3 , Mohammed Alfaqeeh 1,2, Neily Zakiyah 2,4, Fredrick Dermawan Purba 5,6, Cherry Rahayu7, Asrul Akmal Shafie 8, Dwi Endarti 9, 10, Auliya A Suwantika 2,4,6  \n1Doctoral Program of Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, West Java, Indonesia; 2Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, West Java, Indonesia; 3Department of Pharmacy, Faculty of Health Sciences, Universitas Jenderal Soedirman, Banyumas, Central Java, Indonesia; 4Centre of Excellence for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, West Java, Indonesia; 5Department of Clinical and Health Psychology, Faculty of Psychology, Universitas Padjadjaran, Bandung, West Java, Indonesia; 6Center for Health Technology Assessment, Universitas Padjadjaran, Bandung, West Java, Indonesia; 7Hasan Sadikin Hospital, Bandung, West Java, Indonesia; 8Discipline of Social and Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Gelugor, Penang, Malaysia; 9Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia; 10Center for Pharmacoeconomic and Health Technology Assessment, Universitas Gadjah Mada, Yogyakarta, Indonesia  \nCorrespondence: Auliya A Suwantika, Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jalan Raya Bandung-Sumedang KM 21, Bandung, West Java, 45363, Indonesia, Tel/Fax +62-878-2267-1010, Email [auliya@unpad.ac.id](auliya@unpad.ac.id)  \nBackground: Haemodialysis (HD) is the predominant kidney replacement therapy for end-stage kidney disease (ESKD) in Indonesia, whereas continuous ambulatory peritoneal dialysis (CAPD) is less frequently used. Hypertension is highly prevalent in this population and may impair health-related quality of life (HRQoL) . This study aimed to compare HRQoL between HD and CAPD patients using the EQ-5D-5L instrument.  \nMethods: A prospective observational cohort study was conducted at Dr. Hasan Sadikin General Hospital, Bandung (September 2023– January 2024). Adults with ESKD and hypertension on HD or CAPD for ≥3 months were assessed at baseline, week 2 and week 4 using EQ-5D-5L and EQ-VAS. Socio-demographic and clinical data were obtained from medical records. Baseline differences were examined using χ2/Fisher’s exact and Mann–Whitney U-tests. Longitudinal changes in EQ-5D-5L utility and EQ-VAS were analysed using linear mixed-effects models (LMMs) with random intercepts and fixed effects for time, dialysis modality, age and comorbidity; age×comorbidity and time×comorbidity interactions were explored.  \nResults: Ninety-one patients were included (58 HD, 33 CAPD) . Compared with HD, CAPD patients were younger, more highly educated, more often insured through non-PBI schemes, and had greater comorbidity burden, more frequent use of ≥3 antihypertensive drugs and higher rehospitalisation rates. Mean EQ-5D-5L utility and EQ-VAS scores were similar between modalities at all time points. In LMMs, neither modality nor time showed significant main effects on EQ-5D-5L utility or EQ-VAS (all p>0.05) . For utility, significant age×comorbidity (p=0.002) and time×comorbidity (p=0.032) interactions indicated less favourable trajectories among older, multimorbid patients.  \nConclusion: After accounting for repeated measurements and baseline confounding, short-term overall HRQoL appeared broadly comparable between HD and CAPD. Small numerical advantages for CAPD and the interaction patterns observed in LMMs should be considered hypothesis-generating and require confirmation in larger, methodologically robust studies.","cbCaijv0h6Sf9ZfU","https://ap.wps.com/l/cbCaijv0h6Sf9ZfU","pdf",3127448,16,"English","# Background\n## Study methods\n## Results\n## Conclusion","[{\"question\":\"What was the study objective regarding HRQoL?\",\"answer\":\"To compare health-related quality of life between hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) patients using the EQ-5D-5L instrument.\"},{\"question\":\"How were patients assessed and over what timeline?\",\"answer\":\"Adults with ESKD and hypertension on HD or CAPD for at least 3 months were assessed at baseline, week 2, and week 4 using EQ-5D-5L and EQ-VAS.\"},{\"question\":\"What did the results show about overall short-term HRQoL between modalities?\",\"answer\":\"After accounting for repeated measurements and baseline confounding, short-term overall HRQoL appeared broadly comparable between HD and CAPD.\"}]","Health-Related Quality of Life in Patients End-Stage Kidney Disease with Hypertension - Hemodialysis Vs Continuous Ambulatory Peritoneal Dialysis Using EQ-5D-5L at a Tertiary Center in Indonesia | PDF",1790563692]