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\n[https://doi.org/10.1093/bjsopen/zrae042](https://doi.org/10.1093/bjsopen/zrae042)  \nOriginal Article  \nHealth-related quality of life by type of breast surgery in women with primary breast cancer: prospective longitudinal cohort study  \nKim Gulis1,2,* , Julia Ellbrant2,3 , Pär-Ola Bendahl4, Tor Svensjö1,† and Lisa Rydén2,3,†   \n1Department of Surgery, Kristianstad Central Hospital, Kristianstad, Sweden 2Department of Clinical Sciences Lund, Division of Surgery, Lund University, Lund, Sweden 3Department of Surgery, Skåne University Hospital, Malmö, Sweden  \n4Department of Clinical Sciences Lund, Division of Oncology, Lund University, Lund, Sweden  \n*Correspondence to: Kim Gulis, Department of Surgery, Kristianstad Central Hospital, JA Hedlundsväg 5, Kristianstad SE-29133, Sweden ([e-mail: Kim.Gulis@med.lu.se](e-mail: Kim.Gulis@med.lu.se))†These authors shared the last authorship.  \nAbstract  \nBackground: Health-related quality of life and patient-related outcome measures for patients with cancer have gained increased interest over the last decade. However, few prospective studies with longitudinal data evaluated health-related quality of life inpatients with breast cancer. This study aimed to investigate how health-related quality of life changed from the time of diagnosis to 1 year after breast cancer surgery for the main surgical techniques.  \nMethods: This prospective longitudinal single-centre study included patients with primary breast cancer diagnosed in 2019–2020 who underwent surgery. Patients completed a health-related quality of life questionnaire (Breast-Q) at baseline. One year after surgery, they completed the Breast-Q a second time, the EORTC (European Organization for Research and Treatment of Cancer) quality of life questionnaire-C30 and the quality of life questionnaire-BR23 . Analysis of variance and Kruskal–Wallis tests were used to evaluate the differences in health-related quality of life between surgical groups. Analysis of covariance with robust standard errors was used to adjust for confounders.  \nResults: In total, 340 patients were included in the study; 160 patients received oncoplastic partial mastectomy, 112 received partial mastectomy, 42 received mastectomy and 26 had mastectomy with immediate reconstruction. Patients that had partial mastectomy or oncoplastic partial mastectomy were more satisfied with their breasts (P \u003C 0.001), had a better body image (P = 0.006) and higher sexual functioning scores (P = 0.027) than patients who had a mastectomy with/without reconstruction. The oncoplastic and mastectomy with reconstruction groups had more breast symptoms than other groups (P \u003C 0.001), and the mastectomy group had the least symptoms from the chest area.  \nConclusion: Partial mastectomy and oncoplastic partial mastectomy have the best outcomes in terms of breast satisfaction, body image and sexual functioning. This highlights the importance of preserving the breast when feasible and underscores that breast reconstruction is not equal to breast conservation.  \nRegistration number: NCT04227613 ([http://www.clinicaltrials.gov](http://www.clinicaltrials.gov)).  \nIntroduction  \nBreast cancer affects over 8000 women in Sweden every year and is the most common type of cancer in women1. In 2020, 2.3 million women were diagnosed with breast cancer globally and there were 685 000 breast cancer deaths2. However, the breast cancer prognosis has improved substantially over recent decades because of early diagnosis and multimodal therapy3. Observational studies have repeatedly shown that women who are treated with breast-conserving surgery (BCS) and radiotherapy have the same survival rate as patients treated with mastectomy4 ,5. More recent studies suggested a small increase in survival in favour of BCS with radiation compared with mastectomy6 ,7.  \nApplying oncoplastic breast surgery (OPBS) in BCS allows amore generous resection of breast tissue, which reduces the rate of positive ","cbCaicesISim3pwj","https://ap.wps.com/l/cbCaicesISim3pwj","pdf",415911,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What question did the study aim to answer?\",\"answer\":\"It investigated how health-related quality of life changed from the time of diagnosis to one year after breast cancer surgery, comparing the main surgical techniques.\"},{\"question\":\"How were outcomes measured in the study?\",\"answer\":\"Patients completed Breast-Q at baseline and again one year after surgery, along with EORTC QLQ-C30 and QLQ-BR23.\"},{\"question\":\"Which surgical types showed the best reported outcomes?\",\"answer\":\"Partial mastectomy and oncoplastic partial mastectomy had the best outcomes for breast satisfaction, body image, and sexual functioning compared with mastectomy (with or without reconstruction).\"}]","Health-related quality of life by type of breast surgery in women with primary breast cancer: prospective longitudinal cohort study | PDF",1790002379,23]