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Therapeutic strategies aiming to enhance HDL functionality, including synthetic HDL and ApoA-I mimetics, show promise in animal models. Summary concludes that HDL-protective biology supports AAA pathogenesis control, highlighting HDL-mimetic and HDL-function-improving approaches for future clinical translation.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/hdl-in-abdominal-aortic-aneurysm-mechanistic-insight-and-therapeutic-potential/430079/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/hdl-in-abdominal-aortic-aneurysm-mechanistic-insight-and-therapeutic-potential/430079.png","ImageObject",300,407,{"name":42,"@type":43},"Riley","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-02","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",15,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How does HDL relate to abdominal aortic aneurysm risk?","Question",{"text":63,"@type":64},"Lower HDL-cholesterol levels are consistently associated with a higher risk of AAA. Large epidemiological and genetic studies report an inverse relationship between HDL-C and AAA development and progression.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What mechanisms are described for HDL’s protective effects in AAA?",{"text":68,"@type":64},"HDL is reported to protect via antiinflammatory, antioxidant, and endothelial-protective functions. The review highlights vasoprotective roles including reverse cholesterol transport (RCT), anti-thrombotic, and anti-apoptotic activities.",{"name":70,"@type":61,"acceptedAnswer":71},"What therapeutic strategies targeting HDL functionality are discussed?",{"text":72,"@type":64},"The review discusses approaches aimed at improving or mimicking HDL function, including synthetic HDL (sHDL) and apolipoprotein A-I (ApoA-I) mimetics. These strategies have shown promising results in animal models and are positioned as future avenues for clinical development.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},430079,1790763017,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":146,"preview_page_count":4},1374391975076,"https://ap-avatar.wpscdn.com/avatar/14000253ca4ec9f6853?x-image-process=image/resize,m_fixed,w_180,h_180&k=1783305029341752051","Current Atherosclerosis Reports (2026) 28:6 [https://doi.org/10.1007/s1](https://doi.org/10.1007/s1) 1883-025-01378-9  \nREVIEW  \nHDL in Abdominal Aortic Aneurysm: Mechanistic Insight and Therapeutic Potential  \nJulia C. Catalano1 · Yanhong Guo2 · Brandon M. Bordeau1 · Minzhi Yu1 · Anna Schwendeman1,3  \nReceived: 6 October 2025 / Accepted: 13 December 2025 © The Author(s) 2026  \nAbstract  \nPurpose of Review This review examines the role of high-density lipoprotein (HDL) in the context of abdominal aortic aneurysm (AAA). It focuses on the correlation between HDL and AAA risk, while also exploring the mechanisms by which HDL may protect against AAA progression.  \nRecent Findings Large epidemiological and genetic studies have consistently shown that lower HDL-cholesterol (HDL-C) levels are associated with an increased risk of AAA. HDL exerts a protective effect against AAA formation through its antiinflammatory, antioxidant, and endothelial protective functions. Recent therapeutic strategies aimed at augmenting HDL functionality, including synthetic HDL (sHDL) and apolipoprotein A-I (ApoA-I) mimetics, have demonstrated promising results in animal models.  \nSummary Current evidence supports a protective role for HDL in AAA pathogenesis. Strategies aimed to improve or mimic HDL function represent promising avenues for future AAA treatment, emphasizing the need for continued translational research and clinical development.  \nKeywords Abdominal aortic aneurysm · High-density lipoprotein · Apolipoprotein A-1 · Vascular smooth muscle cells · HDL therapy  \nIntroduction  \nAbdominal aortic aneurysm (AAA) is a life-threatening vascular condition characterized by progressive dilation of the infrarenal aorta greater than 3 cm [1]. AAA is typically asymptomatic and often remains undiagnosed until aortic rupture occurs, an event associated with mortality rates of up to 80%[2, 3]. In the United States, AAA affects approximately 6–8% of adults aged 65 years or older [4]. Current management is  \n􀀍 Minzhi Yu [minzhiyu@umich.edu](minzhiyu@umich.edu)  \n􀀍 Anna Schwendeman [annaschw@umich.edu](annaschw@umich.edu)  \n1 Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA  \n2 Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Medical Center, Ann Arbor, MI, USA  \n3 Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA  \nlimited to surgical repair, generally recommended when aneurysm diameter exceeds 5.5 cm or is rapidly expanding, with the remainder advised to monitor size annually [5]. Despite this, it is estimated that 5–10% of patients under surveillance experience AAA rupture before reaching surgery threshold [6].  \nDyslipidemia is a recognized risk factor for AAA [7, 8]; however, the specific contributions of lipoproteins to AAA pathogenesis remain incompletely understood. High-density lipoprotein (HDL) exerts multiple vasoprotective functions, including reverse cholesterol transport (RCT), anti-inflammatory, anti-thrombotic, and anti-apoptotic activities. Low plasma HDL concentrations are strongly associated with an increased risk of cardiovascular disease, and recent evidence suggests a relationship between HDL deficiency and the development of AAA [9, 10]. Interventions aimed at raising HDL levels or restoring HDL functionality may offer novel strategies for modulating AAA progression. In this review, we provide an overview of HDL biology in AAA, highlighting epidemiological evidence, protective mechanisms, and functional alterations, and discuss how these may inform HDL-based therapeutic approaches aimed at reducing aneurysm progression and rupture.  \n1 3  \nLow HDL is a Risk Factor for AAA  \nHDL are endogenous anti-atherogenic particles that circulate in the plasma. They comprise a hydrophobic core of cholesterol esters and triglycerides enveloped by anamphipathic layer of phospholipids and unesterified cholesterol [11]. Apolipoprotein A-I (ApoA-I),","cbCaipCwX8IdrAey","https://ap.wps.com/l/cbCaipCwX8IdrAey","pdf",1742191,17,"English","# Abstract\n## Purpose of Review\n## Recent Findings\n## Summary\n# Introduction\n## AAA overview and clinical management\n## HDL and dyslipidemia as AAA risk factors\n# Low HDL is a Risk Factor for AAA\n## HDL structure and reverse cholesterol transport\n## Epidemiological evidence linking HDL-C to AAA risk","[{\"question\":\"How does HDL relate to abdominal aortic aneurysm risk?\",\"answer\":\"Lower HDL-cholesterol levels are consistently associated with a higher risk of AAA. Large epidemiological and genetic studies report an inverse relationship between HDL-C and AAA development and progression.\"},{\"question\":\"What mechanisms are described for HDL’s protective effects in AAA?\",\"answer\":\"HDL is reported to protect via antiinflammatory, antioxidant, and endothelial-protective functions. The review highlights vasoprotective roles including reverse cholesterol transport (RCT), anti-thrombotic, and anti-apoptotic activities.\"},{\"question\":\"What therapeutic strategies targeting HDL functionality are discussed?\",\"answer\":\"The review discusses approaches aimed at improving or mimicking HDL function, including synthetic HDL (sHDL) and apolipoprotein A-I (ApoA-I) mimetics. These strategies have shown promising results in animal models and are positioned as future avenues for clinical development.\"}]","HDL in Abdominal Aortic Aneurysm - Mechanistic Insight and Therapeutic Potential | PDF",1790651863,43]