[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-334047-105":59,"doc-detail-334047-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","hdac1-a-promising-target-for-cancer-treatment-insights-from-a-thorough-analysis-of-tumor-functions","HDAC1 - a promising target for cancer treatment - insights from a thorough analysis of tumor functions","","HDAC1 is identified as a clinically relevant epigenetic enzyme linked to tumor development and prognosis, yet previous studies often focused on single cancers. This work performs a pan-cancer investigation across 33 tumor types using public databases and experimental validation, including tube formation assays and immunohistochemistry. Results show high HDAC1 expression, associations between HDAC1 mRNA levels and patient outcomes, and functional inhibition of endothelial migration by HDAC1 knockdown-conditioned media. Findings also connect HDAC1 to inflammation-related infiltration and phosphorylation patterns, supporting HDAC1 as a candidate target for adjuvant therapies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/hdac1-a-promising-target-for-cancer-treatment-insights-from-a-thorough-analysis-of-tumor-functions/334047/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/hdac1-a-promising-target-for-cancer-treatment-insights-from-a-thorough-analysis-of-tumor-functions/334047.png","ImageObject",300,407,{"name":92,"@type":93},"Skyler","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main research objective of the study on HDAC1?","Question",{"text":112,"@type":113},"To evaluate the prognostic and oncogenic effects of HDAC1 across 33 tumor types through pan-cancer analysis and supporting experiments.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which databases and experimental approaches were used to study HDAC1 functions?",{"text":117,"@type":113},"TCGA and GEO databases were used, along with TIMER2, GEPIA2, GTEx, CPTAC, and UALCAN. Functional assays included tube formation, and protein expression was assessed using immunohistochemistry; siRNA knockdown was applied in HCC cell lines.",{"name":119,"@type":110,"acceptedAnswer":120},"What key findings connect HDAC1 with cancer progression and patient prognosis?",{"text":121,"@type":113},"HDAC1 showed high expression across many tumors, and HDAC1 mRNA levels correlated with patient prognosis. Conditioned media from HDAC1 siRNA-treated HCC cells inhibited HUVEC tube formation and migration, and HDAC1 expression related to inflammatory cell infiltration in multiple cancers.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},334047,1790998850,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36},2336464648746,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","HDAC1: a promising target for cancer treatment: insights from a thorough analysis of tumor functions  \nJiaojiao Xie1,2\\#, Rui Liu3\\#, Ying Cai4, Dina Liu4^  \n1Department of Respiratory Medicine, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China; 2Department of Emergency, Chongqing Western Hospital, Chongqing, China; 3Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China; 4Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Chongqing Medical University, Chongqing, China Contributions: (I) Conception and design: D Liu; (II) Administrative support: J Xie; (III) Provision of study materials or patients: R Liu; (IV) Collection and assembly of data: R Liu; (V) Data analysis and interpretation: Y Cai; (VI) Manuscript writing: All authors; (VII) Final approval of  \nmanuscript: All authors.  \n\\#These authors contributed equally to this work.  \nCorrespondence to: Dina Liu, PhD. Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Chongqing Medical University, 76\\#, Linjiang Road, Yuzhong District, Chongqing 400000, [China. Email: DinaLiu@cqmu.edu.cn](China. Email: DinaLiu@cqmu.edu.cn).  \nBackground: Many significant findings from recent studies have revealed the significance of histone deacetylase 1 (HDAC1) in the development of tumors and its strong association with tumor prognosis; these studies have mainly focused on one single cancer such as in lung cancer, breast cancer, and hepatocellular carcinoma (HCC) . To date, there has been no comprehensive analysis and pan-analysis conducted from the overall perspective of cancer across all types. Hence, we analyzed public databases, conducted tube formation assay, and immunohistochemistry (IHC) staining of HDAC1 on six kinds of clinical samples to explore the prognostic and oncogenic effects of HDAC1 on 33 tumors for the first time. There currently remains a lack of efficient testing methods, therapies, and diagnostic and prognostic markers of tumor formation and  \ndevelopment in different tumors.  \nMethods: Our initial objective was to investigate the possible cancer-causing functions of HDAC1 in 33 different types of tumors by utilizing The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, and many different online websites, such as Tumor IMmune Estimation Resource 2 (TIMER2), Gene Expression Profiling Interactive Analysis 2 (GEPIA2), Genotype Tissue Expression (GTEx) database, Clinical Proteomic Tumor Analysis Consortium (CPTAC) dataset, and University of ALabama at Brimingham CANcer data analysis portal (UALCAN) tool, and so on. We even used small interfering RNA  \n(siRNA) to knock down HDAC2 in HCC cell lines. IHC of HDAC1 was performed.  \nResults: HDAC1 exhibited high expression in numerous tumors, and strong correlations were observed between the messenger RNA (mRNA) levels of HDAC1 and the prognosis of individuals diagnosed with tumors. Human umbilical vein endothelial cells (HUVECs) tube formation and migration were significantly inhibited by conditioned media from HCC cells treated with siRNA of HDAC1 . Several types of cancer have been found to exhibit elevated levels of phosphorylation at S421 . Furthermore, as in bladder urothelial carcinoma (BLCA), breast invasive carcinoma (BRCA), and kidney renal papillary cell carcinoma (KIRP),  \nHDAC1 expression was found to be correlated with inflammatory cell infiltration.  \nConclusions: The levels of HDAC1 are expected to adapt to clinical adjuvant targeted therapy in most  \ntypes of solid cancer.  \nKeywords: Histone deacetylase 1 (HDAC1); epigenetic enzyme; tumorigenesis; inflammation; cancer therapy  \n^ ORCID: 0000-0001-5456-0159.  \n© AME Publishing Company. Trans","cbCaiclwfL6IK0cs","https://ap.wps.com/l/cbCaiclwfL6IK0cs","pdf",3884118,16,"English","# Introduction\n# Methods\n# Results\n# Conclusions\n# Highlight box: Key findings and what is known/new","[{\"question\":\"What is the main research objective of the study on HDAC1?\",\"answer\":\"To evaluate the prognostic and oncogenic effects of HDAC1 across 33 tumor types through pan-cancer analysis and supporting experiments.\"},{\"question\":\"Which databases and experimental approaches were used to study HDAC1 functions?\",\"answer\":\"TCGA and GEO databases were used, along with TIMER2, GEPIA2, GTEx, CPTAC, and UALCAN. Functional assays included tube formation, and protein expression was assessed using immunohistochemistry; siRNA knockdown was applied in HCC cell lines.\"},{\"question\":\"What key findings connect HDAC1 with cancer progression and patient prognosis?\",\"answer\":\"HDAC1 showed high expression across many tumors, and HDAC1 mRNA levels correlated with patient prognosis. Conditioned media from HDAC1 siRNA-treated HCC cells inhibited HUVEC tube formation and migration, and HDAC1 expression related to inflammatory cell infiltration in multiple cancers.\"}]","HDAC1 - a promising target for cancer treatment - insights from a thorough analysis of tumor functions | PDF",1790005133]