[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-415064-105":59,"doc-detail-415064-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","hashimotos-encephalopathy-induced-personality-changes-a-rare-case-report","Hashimoto’s Encephalopathy-Induced Personality Changes: A Rare Case Report","","SREAT, also known as Hashimoto’s encephalopathy (HE), is an autoimmune thyroiditis–associated disorder characterized by dramatic steroid responsiveness and diverse neuropsychiatric presentations. This rare letter describes a 45-year-old woman with prolonged nicotine use disorder and prominent, predominantly impulsive stealing behavior, alongside abnormal affect, impaired judgment, and significant personality change. Extensive psychiatric evaluation excluded primary mania, psychosis, obsessive disorders, seizure features, and other psychoactive substance use. Thyroiditis evidence and elevated anti-thyroid antibodies guided treatment, with parenteral steroids producing marked improvement within 10 days and sustained behavioral remission during follow-up.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/hashimotos-encephalopathy-induced-personality-changes-a-rare-case-report/415064/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/hashimotos-encephalopathy-induced-personality-changes-a-rare-case-report/415064.png","ImageObject",300,407,{"name":92,"@type":93},"Jake","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",15,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is SREAT/Hashimoto’s encephalopathy and what diagnostic feature is highlighted?","Question",{"text":113,"@type":114},"SREAT (steroid-responsive encephalopathy associated with autoimmune thyroiditis) is an autoimmune disorder that can produce broad neuropsychiatric symptoms, with a key hallmark being a dramatic response to steroids.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What clinical behaviors and psychiatric findings were reported in the case?",{"text":118,"@type":114},"The patient showed anxiety, nicotine craving, intense urge to steal, impaired personal judgment, and insight limited to five. The stealing was impulsive, without evidence of psychotic symptoms, persistent low mood, suicidality, aggression, or seizure-like events.",{"name":120,"@type":111,"acceptedAnswer":121},"How was the patient evaluated and what treatment led to improvement?",{"text":122,"@type":114},"Investigations showed hypothyroidism with ultrasound features suggestive of thyroiditis and elevated anti-thyroid peroxidase and anti-thyroglobulin antibodies. Treatment with parenteral methylprednisolone followed by thyroxine supplements produced symptom improvement within 10 days and no recurrence of previously noted behavioral changes during six months of follow-up.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},415064,1790763982,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":81,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":39,"preview_page_count":4},962084928904,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Letter to the Editor  \nHashimoto’s Encephalopathy-Induced Personality Changes: A Rare Case Report  \nS  \nteroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), also known as  \nHashimoto’s encephalopathy (HE), is an autoimmune disorder that can present with a wide range of neuropsychiatric symptoms.1 The characteristic feature of SREAT is the dramatic response to steroids.2 The most commonly associated neuropsychiatric symptoms are psychosis, followed by depression and dementia.1,3 There have been a few reports of SREAT-related generalized anxiety disorder, mania, conversion, and amnestic disorders.3,4 This, to our knowledge, is the first documented case of personality changes associated with SREAT.  \nCase Report  \nA 45-year-old married female was brought by her husband with nicotine use disorder5 for 16 years and stealing behavior for 10 years. She started using nicotine in flavored chewable form, driven by its smell, and later by the kick it gave. She remained abstinent from nicotine for about five years due to its unavailability following the government-imposed ban. However, after five years, she managed to procure it. Due to increased craving for nicotine, she started stealing petty cash from her husband. Then she started stealing expensive items from friends and family, selling them, and then buying jewellery, expensive clothes, and accessories. After a few thefts, she felt guilty and confessed everything to her husband. However, she continued to steal, feeling an urge to do so. About eight years ago, she underwent infertility treatment, during which she was given de-addiction therapy. She eventually conceived through in vitro fertilization. There were no records of thyroid abnormalities in the patient, but the child had neonatal hypothyroidism. Occasionally, she was found to exhibit episodes  \nof abnormal behaviours such as licking water and walking on four legs like a dog, and rolling on the floor, claiming tobe a mentally ill person. She sometimes undressed herself and jumped on the bed to attract her husband’s attention. Husband noticed she became manipulative, self-centred, short-tempered, a habitual liar, and adamant. She was keen on grooming herself well. She was disrespectful toward her relatives, which was unlike her usual self. She was reluctant to care for her child or to handle household chores. There was one event of an impulsive drug overdose following a trivial conflict with her husband and repeated threatening behaviour. She was taken to a psychiatrist and was treated with divalproex (1,000 mg/d), fluvoxamine (80 mg/d), paroxetine (50 mg/d), and aripiprazole (5 mg/day) for an adequate trial with no response. There was no evidence of medication-related exacerbation of symptoms (Figure 1) .  \nMental status examination revealed anxious affect, nicotine craving, an intense urge to steal, impaired personal judgment, and an insight of five. Neurological examination was within normal limits.  \nShe was stealing valuable items, unlike kleptomania, and neither had associated tension or guilt. The acts were predominantly impulsive. There were  \nno hyper-sexuality, hyper-religiosity, or sleep disturbances, which ruled out mania. There were no obsessive thoughts or behaviour. There was no evidence of psychotic symptoms. There was no low mood, suicidality, or aggression. The behavioural changes did not follow any stereotypy, nor were they associated with any seizure-like event, which helped exclude seizure. There was no other psychoactive substance use. It is noteworthy that her sister had a history of nicotine use, but is currently abstinent.  \nInvestigations revealed hypothyroidism, and an ultrasound of the thyroid showed features suggestive of thyroiditis. Anti-thyroid peroxidase and anti-thyroglobulin antibodies were elevated, suggesting Hashimoto’s thyroiditis3,6 (Table 1) .  \nThe neurologist’s opinion was sought, and the patient was treated with parenteral steroids: A methylprednisolone 1 g","cbCairoGnGAdQhL2","https://ap.wps.com/l/cbCairoGnGAdQhL2","pdf",1417680,"English","# Case Report\n## Mental Status and Differential Considerations\n## Investigations\n## Treatment and Outcome\n## Table 1. Reports of Investigations","[{\"question\":\"What is SREAT/Hashimoto’s encephalopathy and what diagnostic feature is highlighted?\",\"answer\":\"SREAT (steroid-responsive encephalopathy associated with autoimmune thyroiditis) is an autoimmune disorder that can produce broad neuropsychiatric symptoms, with a key hallmark being a dramatic response to steroids.\"},{\"question\":\"What clinical behaviors and psychiatric findings were reported in the case?\",\"answer\":\"The patient showed anxiety, nicotine craving, intense urge to steal, impaired personal judgment, and insight limited to five. The stealing was impulsive, without evidence of psychotic symptoms, persistent low mood, suicidality, aggression, or seizure-like events.\"},{\"question\":\"How was the patient evaluated and what treatment led to improvement?\",\"answer\":\"Investigations showed hypothyroidism with ultrasound features suggestive of thyroiditis and elevated anti-thyroid peroxidase and anti-thyroglobulin antibodies. Treatment with parenteral methylprednisolone followed by thyroxine supplements produced symptom improvement within 10 days and no recurrence of previously noted behavioral changes during six months of follow-up.\"}]","Hashimoto’s Encephalopathy-Induced Personality Changes: A Rare Case Report | PDF",1790599868]