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While these enzymes support early diagnosis, they do not reliably specify disease etiology and offer limited mechanistic insight into progression. The discussion highlights increased cytokines—especially IL-6, TNF-α, and IL-8—as candidates for predicting severity. Integrating such biomarkers with enzymatic and prognostic scoring systems may improve accuracy and enable earlier, more effective patient management.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/harnessing-early-enzymatic-biomarkers-and-cytokines-for-risk-prediction-in-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis/406430/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/harnessing-early-enzymatic-biomarkers-and-cytokines-for-risk-prediction-in-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis/406430.png","ImageObject",300,407,{"name":92,"@type":93},"Cart","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",16,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why are 4-hour serum amylase and lipase considered for early prediction after ERCP pancreatitis?","Question",{"text":113,"@type":114},"Because they can enable early diagnosis and reflect early pancreatic injury mechanisms shortly after ERCP, helping identify patients soon after the procedure.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What limitations do amylase and lipase have for risk prediction?",{"text":118,"@type":114},"They lack specificity for disease etiology and provide limited insight into the molecular mechanisms driving disease severity and progression.",{"name":120,"@type":111,"acceptedAnswer":121},"Which cytokines are highlighted as potential predictors of post-ERCP pancreatitis severity?",{"text":122,"@type":114},"Interleukin-6 (IL-6) is emphasized, along with tumor necrosis factor-alpha (TNF-α) and IL-8, which are increased in post-ERCP pancreatitis and may predict severity.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},406430,1790866145,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},18829141979164,"https://eur-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","| W | J | G | World Journal of\u003Cbr>Gastroenterology |\n| --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastroenterol 2025 December 28; 31(48): 114786  \nDOI: 10.3748/wjg.v31.i48.114786 ISSN 1007-9327 (print) ISSN 2219-2840 (online)  \nEDITORIAL  \nHarnessing early enzymatic biomarkers and cytokines for risk prediction in post-endoscopic retrograde cholangiopancreatography pancreatitis  \nAbdellatif Bouayad  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade B, Grade B  \nNovelty: Grade B, Grade C  \nCreativity or Innovation: Grade B, Grade C  \nScientific Significance: Grade B, Grade B  \nP-Reviewer: Saeed S, PhD, China; Yang F, MD, Professor, China  \nReceived: September 27, 2025  \nRevised: October 28, 2025  \nAccepted: November 12, 2025  \nPublished online: December 28, 2025  \nProcessing time: 90 Days and 9.5 Hours  \nAbdellatif Bouayad, Laboratory of Immunology, Mohammed First University, Faculty of Medicine and Pharmacy Oujda, Oujda-Angad 4867, Oriental, Morocco  \nCorresponding author: Abdellatif Bouayad, MD, Associate Professor, Laboratory of Immunology, Mohammed First University, Faculty of Medicine and Pharmacy Oujda, 4867 Oujda l’Université, Oujda-Angad 4867, Oriental, [Morocco.](Morocco. a.bouayad@ump.ac.ma)[ a.bouayad@ump.ac.ma](Morocco. a.bouayad@ump.ac.ma)  \nAbstract  \nThis editorial critically analyses the recent article by Jung et al, which investigates the utility of 4-hour serum amylase and lipase as early blood markers for postendoscopic retrograde cholangiopancreatography (ERCP) acute pancreatitis prediction. Although these enzymes are valuable for the early diagnosis of postERCP pancreatitis, they lack specificity for disease etiology and provide limited insight into the molecular mechanisms underlying disease progression. Several cytokines, notably interleukin (IL)-6, tumor necrosis factor-alpha, and IL-8, are increased in post-ERCP pancreatitis and may serve as potential predictors for disease severity. The incorporation of these biomarkers in early enzymatic biomarkers and established prognostic scoring systems could further enhance their accuracy and allow for earlier, more effective management of patients with postERCP pancreatitis.  \nKey Words: Cytokines; Enzymatic biomarkers; Post-endoscopic retrograde cholangiopancreatography pancreatitis; Early diagnosis; Prognosis  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: Although high serum 4-hour amylase and lipase levels enable early diagnosis of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis, they have limited prognostic value and lack etiological specificity. Interleukin (IL)-6 has emerged as an early inflammatory biomarker for predicting post-ERCP pancreatitis severity. However, detection and quantification of this cytokine remain costly. Validation of rapid, cost-effective, and point-of-care IL-6 immunoassays is essential for their integration into routine clinical practice for post-ERCP pancreatitis risk prediction.  \n WJG  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 28, 2025  Volume 31  Issue 48   \nBouayad A. Biomarkers and cytokines in post-ERCP pancreatitis  \nCitation: Bouayad A. Harnessing early enzymatic biomarkers and cytokines for risk prediction in post-endoscopic retrograde cholangiopancreatography pancreatitis. World J Gastroenterol 2025; 31(48): 114786  \nURL: [https://www.wjgnet.com/1007-9327/full/v31/i48/114786.htm](https://www.wjgnet.com/1007-9327/full/v31/i48/114786.htm)  \nDOI: [https://dx.doi.org/10.3748/wjg.v31.i48.114786](https://dx.doi.org/10.3748/wjg.v31.i48.114786)  \nINTRODUCTION  \nAcute post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis is an inflammatory condition of the pancreas characterized ","cbCail1xjwoik1PG","https://ap.wps.com/l/cbCail1xjwoik1PG","pdf",601616,"English","# Editorial\n## Abstract\n## Key Words\n## Core Tip\n## Introduction\n## Early enzymatic biomarkers and their limitations in the diagnosis of post-ERCP pancreatitis","[{\"question\":\"Why are 4-hour serum amylase and lipase considered for early prediction after ERCP pancreatitis?\",\"answer\":\"Because they can enable early diagnosis and reflect early pancreatic injury mechanisms shortly after ERCP, helping identify patients soon after the procedure.\"},{\"question\":\"What limitations do amylase and lipase have for risk prediction?\",\"answer\":\"They lack specificity for disease etiology and provide limited insight into the molecular mechanisms driving disease severity and progression.\"},{\"question\":\"Which cytokines are highlighted as potential predictors of post-ERCP pancreatitis severity?\",\"answer\":\"Interleukin-6 (IL-6) is emphasized, along with tumor necrosis factor-alpha (TNF-α) and IL-8, which are increased in post-ERCP pancreatitis and may predict severity.\"}]","Harnessing early enzymatic biomarkers and cytokines for risk prediction in post-endoscopic retrograde cholangiopancreatography pancreatitis | PDF",1790565618,18]