[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-426250-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-426250-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","handgrip-strength-depressive-symptoms-and-cognitive-function-in-older-mexican-american-adults","HANDGRIP STRENGTH, DEPRESSIVE SYMPTOMS, AND COGNITIVE FUNCTION IN OLDER MEXICAN AMERICAN ADULTS","","High depressive symptoms (DS) relate to cognitive decline, while higher handgrip strength (HGS) relates to less cognitive decline. This study assessed nativity differences in the HGS–DS association with cognitive impairment (CI) over 12 years among 984 Mexican American adults aged 75+ with baseline MMSE ≥ 21. CI was MMSE \u003C 21, HGS was low/high by sex cutoffs, and high DS used CES-D ≥ 16, adjusting for socio-demographics and health. Findings support targeting both DS and physical strength to improve cognition.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/handgrip-strength-depressive-symptoms-and-cognitive-function-in-older-mexican-american-adults/426250/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/handgrip-strength-depressive-symptoms-and-cognitive-function-in-older-mexican-american-adults/426250.png","ImageObject",300,407,{"name":42,"@type":43},"eBook King","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-12","2026-09-28",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How were cognitive impairment and handgrip strength defined in the study?","Question",{"text":63,"@type":64},"Cognitive impairment (CI) was defined as an MMSE score \u003C 21. Handgrip strength (HGS) was classified as low or high using sex-specific cutoffs: \u003C27/≥27 kg for men and \u003C16/≥16 kg for women.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What relationship did the study find between HGS, depressive symptoms, and CI over time?",{"text":68,"@type":64},"Across participants, lower DS together with low or high HGS was associated with markedly lower odds of CI over time compared with the low HGS-high DS group, after adjusting for covariates.",{"name":70,"@type":61,"acceptedAnswer":71},"Did the association between depressive symptoms and CI differ by nativity?",{"text":72,"@type":64},"Yes. Among foreign-born participants with high DS, high HGS was significantly associated with lower odds of CI over time, while this association was not observed among US-born participants with high DS.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},426250,1790740927,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":22,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":30},962088006270,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Innovation in Aging, 2025, Vol. 9, No. S2 1127  \nAbstract citation ID: igaf122.3781  \nHANDGRIP STRENGTH, DEPRESSIVE SYMPTOMS,  \nAND COGNITIVE FUNCTION IN OLDER MEXICAN  \nAMERICAN ADULTS  \nDivya Kashyap1, and Soham AlSnih2, 1. University of Texas Medical Branch, Galveston, Texas, United States, 2. The University of Texas Medical Branch at Galveston, Texas, Galveston, Texas, United States  \nHigh depressive symptoms (DS) are associated with cognitive decline, while high handgrip strength (HGS) is associated with lower cognitive decline. This study examined nativity differences in the relationship between HGS and DS with cognitive impairment (CI) over a 12-year period among 984 Mexican American adults aged 75 and older who scored ≥21 on the Mini-Mental State Examination (MMSE) at baseline. CI was defined as an MMSE score \u003C 21. HGS was classified as low or high (\u003C 27/≥27 kg for men, \u003C 16/≥16 kg for women), and high DS was defined as ascore ≥16 on the Center for Epidemiologic Studies Depression Scale. Covariates included socio-demographics and health characteristics. Participants were categorized into four groups: low HGS-high DS, low HGS-low DS, high HGS-low DS, and high HGS-high DS. Among US-born participants, those in the low HGS-low DS and high HGS-low DS groups had 59% and 60% lower odds of CI over time, respectively, compared to the low HGS-high DS group, controlling for covariates. Foreign-born participants in the low HGS-low DS, high HGS-low DS, and high HGS-high DS groups had 67%, 73%, and 80% lower odds of CI over time, respectively, compared to the low HGS-high DS group, controlling for covariates. Among foreign-born participants with high DS, high HGS was significantly associated with 24% lower odds of CI over time, but this association was not found among US-born participants with high DS, controlling for covariates. These findings suggest that interventions targeting both DS and physical strength may benefit cognitive health in this population.","cbCairrOUhReDYFW","https://ap.wps.com/l/cbCairrOUhReDYFW","pdf",1005992,"English","# Study Objective and Design\n## Participants and Measures\n## Grouping, Covariates, and Outcomes","[{\"question\":\"How were cognitive impairment and handgrip strength defined in the study?\",\"answer\":\"Cognitive impairment (CI) was defined as an MMSE score \\u003c 21. Handgrip strength (HGS) was classified as low or high using sex-specific cutoffs: \\u003c27/≥27 kg for men and \\u003c16/≥16 kg for women.\"},{\"question\":\"What relationship did the study find between HGS, depressive symptoms, and CI over time?\",\"answer\":\"Across participants, lower DS together with low or high HGS was associated with markedly lower odds of CI over time compared with the low HGS-high DS group, after adjusting for covariates.\"},{\"question\":\"Did the association between depressive symptoms and CI differ by nativity?\",\"answer\":\"Yes. Among foreign-born participants with high DS, high HGS was significantly associated with lower odds of CI over time, while this association was not observed among US-born participants with high DS.\"}]","HANDGRIP STRENGTH, DEPRESSIVE SYMPTOMS, AND COGNITIVE FUNCTION IN OLDER MEXICAN AMERICAN ADULTS | PDF",1790639929]