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When disordered proliferation persists, ISCs can transition into a cancerous state. Gut microbiota at the mucosal barrier surface interacts continuously with ISCs; microbial metabolites regulate ISC and progenitor proliferation via transcription factors. In steady state, differentiated colonocytes degrade these metabolites, protecting ISCs within gut crypts. Future gut flora and metabolites may enable therapeutic control of ISC differentiation in enteropathies.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/gut-microbiota-modulating-intestinal-stem-cell-differentiation-editorial/341408/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/gut-microbiota-modulating-intestinal-stem-cell-differentiation-editorial/341408.png","ImageObject",300,407,{"name":92,"@type":93},"Noah","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is intestinal stem cell (ISC) differentiation important in inflammatory states?","Question",{"text":113,"@type":114},"ISC proliferation and differentiation are critical for replacing damaged gut mucosal epithelial cells, which helps ameliorate gut inflammation.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How can dysregulated ISC proliferation contribute to cancer?",{"text":118,"@type":114},"When disordered proliferation continues, ISCs can enter a cancerous state, supporting intestinal cancer development.",{"name":120,"@type":111,"acceptedAnswer":121},"What role does gut microbiota play in regulating ISC behavior?",{"text":122,"@type":114},"Gut microbiota interacts with ISCs over the mucosal barrier surface; microbial metabolites regulate ISC and progenitor proliferation through transcription factors.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},341408,1790647810,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},8796095462418,"https://ap-avatar.wpscdn.com/avatar/80000253c1241d02b47?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778826106357471780","| W | J | S | C | World Journal of\u003Cbr>Stem Cells |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Stem Cells 2024 June 26; 16(6): 619-622  \nDOI: 10.4252/wjsc.v16.i6.619 ISSN 1948-0210 (online)  \nEDITORIAL  \nGut microbiota modulating intestinal stem cell differentiation  \nLin He, Chen Zhu, Xiang-Feng Zhou, Shu-E Zeng, Le Zhang, Kuan Li  \nSpecialty type: Cell and tissue engineering  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade A  \nNovelty: Grade A  \nCreativity or Innovation: Grade A  \nScientific Significance: Grade A  \nP-Reviewer: Salvadori M, Italy  \nReceived: February 22, 2024  \nRevised: May 6, 2024  \nAccepted: May 20, 2024  \nPublished online: June 26, 2024  \nProcessing time: 124 Days and 1.5 Hours  \nLin He, Xiang-Feng Zhou, Kuan Li, Department of Alcohol and Drug Dependence Treatment, The Mental Hospital of Yunnan Province, Kunming 650224, Yunnan Province, China  \nChen Zhu, Department of Physical Education, Kunming Medical University, Kunming 650500, Yunnan Province, China  \nShu-E Zeng, Department of Geriatric Psychiatry, The Mental Hospital of Yunnan Province, Kunming 650224, Yunnan Province, China  \nLe Zhang, Sleep Medicine Center, The Mental Hospital of Yunnan Province, Kunming 650224, Yunnan Province, China  \nCorresponding author: Kuan Li, PhD, Doctor, Department of Alcohol and Drug Dependence Treatment, The Mental Hospital of Yunnan Province, No. 733 Chuanjin Road, Panlong District, Kunming 650224, Yunnan Province, [China.](China. n_kli_sxwang@163.com)[ n_kli_sxwang@163.com](China. n_kli_sxwang@163.com)  \nAbstract  \nProliferation and differentiation of intestinal stem cell (ISC) to replace damaged gut mucosal epithelial cells in inflammatory states is a critical step in ameliorating gut inflammation. However, when this disordered proliferation continues, it induces the ISC to enter a cancerous state. The gut microbiota on the free surface of the gut mucosal barrier is able to interact with ISC on a sustained basis. Microbiota metabolites are able to regulate the proliferation of gut stem and progenitor cells through transcription factors, while in steady state, differentiated colonocytes are able to break down such metabolites, thereby protecting stem cells at the gut crypt. In the future, the gut flora and its metabolites mediating the regulation of ISC differentiation will be a potential treatment for enteropathies.  \nKey Words: Intestinal stem cells; Gut microbiota; Gut stem niche; Microenvironment; Probiotics  \n©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: The dysbiosis may cause intestinal cancer. when the proliferation of the stem cells attempting to repair the loss of integrity of the gut barrier. The correction of the gut stem niche dysbiosis by the assumption of some beneficial microbiota could be a specific therapy of this disease.  \n WJSC  [https://www.wjgnet.com](https://www.wjgnet.com) 619 June 26, 2024  Volume 16  Issue 6   \nHe L et al. Gut microbiota and ISC  \nCitation: He L, Zhu C, Zhou XF, Zeng SE, Zhang L, Li K. Gut microbiota modulating intestinal stem cell differentiation. World J Stem Cells 2024; 16(6): 619-622  \nURL: [https://www.wjgnet.com/1948-0210/full/v16/i6/619.htm](https://www.wjgnet.com/1948-0210/full/v16/i6/619.htm)  \nDOI: [https://dx.doi.org/10.4252/wjsc.v16.i6.619](https://dx.doi.org/10.4252/wjsc.v16.i6.619)  \nINTRODUCTION  \nInflammatory bowel disease and irritable bowel syndrome have become global diseases. In the inflammatory state that occurs, proliferation and differentiation of intestinal stem cells (ISCs) to replace damaged gut mucosal epithelial cells is a critical step in ameliorating gut inflammation[1] . ISCs at the gut crypts have the ability to continuously proliferate and differentiate into different types of gut mucosal epi","cbCaivHyvwI9GnMm","https://ap.wps.com/l/cbCaivHyvwI9GnMm","pdf",353696,"English","# Abstract\n# Core Tip\n# Introduction\n# Stem Cell Niche Regulate ISCs\n## Competitive inhibition\n## Balance of renewal and differentiation","[{\"question\":\"Why is intestinal stem cell (ISC) differentiation important in inflammatory states?\",\"answer\":\"ISC proliferation and differentiation are critical for replacing damaged gut mucosal epithelial cells, which helps ameliorate gut inflammation.\"},{\"question\":\"How can dysregulated ISC proliferation contribute to cancer?\",\"answer\":\"When disordered proliferation continues, ISCs can enter a cancerous state, supporting intestinal cancer development.\"},{\"question\":\"What role does gut microbiota play in regulating ISC behavior?\",\"answer\":\"Gut microbiota interacts with ISCs over the mucosal barrier surface; microbial metabolites regulate ISC and progenitor proliferation through transcription factors.\"}]","Gut microbiota modulating intestinal stem cell differentiation - Editorial | PDF",1790041772,13]