[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-368446-105":59,"doc-detail-368446-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","gut-microbiota-and-their-influence-in-brain-cancer-milieu","Gut microbiota and their influence in brain cancer milieu","","Gut microbial communities act as adaptive, evolving entities shaped by selective pressures, performing roles in nutrition, metabolism, and immune regulation across the body. Research on the gut microbiome has revealed reciprocal links between the gut microbiota and cognitive functioning, where gut dysbiosis disrupts homeostatic cognition. Such dysbiosis is associated with chronic diseases including brain cancer subtypes like glioma and glioblastoma. This review details mechanistic dysbiosis-driven progression, microbial metabolite regulation (e.g., short-chain fatty acids, amino acids, lipids), and microbiota-mediated effects on therapeutic regimen efficiency, supporting biomarker and target development for improved outcomes.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/gut-microbiota-and-their-influence-in-brain-cancer-milieu/368446/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/gut-microbiota-and-their-influence-in-brain-cancer-milieu/368446.png","ImageObject",300,407,{"name":92,"@type":93},"Connor ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How does gut dysbiosis relate to cognitive functioning?","Question",{"text":113,"@type":114},"Dysbiosis in gut microbial composition disturbs homeostatic cognitive functioning through the reciprocal interaction between the gut microbiome and cognition.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which brain cancer types are discussed in relation to dysbiosis?",{"text":118,"@type":114},"The review links gut dysbiosis with brain cancer, including glioma and glioblastoma, as part of dysbiosis-mediated progression.",{"name":120,"@type":111,"acceptedAnswer":121},"What roles do gut microbial metabolites play in tumour progression?",{"text":122,"@type":114},"Microbial metabolites produced by gut microbiota, such as short-chain fatty acids, amino acids, and lipids, are described as regulatory factors influencing tumour progression.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},368446,1790218066,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},687207022233,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","BharathwajChetty et al. Journal of Neuroinflammation (2025) 22:129 Journal of Neuroinflammation  \n[https://doi.org/10.1186/s12974-025-03434-2](https://doi.org/10.1186/s12974-025-03434-2)  \nREVIEW Open Access  \nGut microbiota and their influence in brain cancer milieu  \nBandari BharathwajChetty 1, Aviral Kumar 1, Pranav Deevi 1,2, Mohamed Abbas3, Athba Alqahtani4, Liping Liang5, Gautam Sethi6,7*, Le Liu8,9* and Ajaikumar B Kunnumakkara 1,2*  \nAbstract  \nMicrobial communities are not simply remnants of the past but dynamic entities that continuously evolve under the selective pressures of nature, reflecting the intricate and adaptive processes of evolution. The microbiota residing in the various regions of the human body has numerous roles in different physiological processes such as nutrition, metabolism, immune regulation, etc. In the zeal of achieving empirical insights into the ambit of the gut microbiome, the research over the years led to the revelation of reciprocal interaction between the gut microbiome and the cognitive functioning of the human body. Dysbiosis in the gut microbial composition disturbs the homeostatic cognitive functioning of the human body. This dysbiosis has been associated with various chronic diseases, including brain cancer, such as glioma, glioblastoma, etc. This review explores the mechanistic role of dysbiosis-mediated progression of brain cancers and their subtypes. Moreover, it demonstrates the regulatory role of microbial metabolites produced by the gut microbiota, such as short-chain fatty acids, amino acids, lipids, etc., in the tumour progression. Further, we also provide valuable insights into the microbiota mediating the efficiency of therapeutic regimens, thereby leveraging gut microbiota as potential biomarkers and targets for improved treatment outcomes.  \nKeywords Gut microbiome, Gut brain axis, Brain cancer, Glioma, Glioblastoma, Tumour micro-environment, Metabolites, Immune modulation, Probiotics  \n*Correspondence: Gautam Sethi[phcgs@nus.edu.sg](phcgs@nus.edu.sg)[ ](phcgs@nus.edu.sg)Le Liu [1402744723@smu.edu.cn](1402744723@smu.edu.cn)  \nAjaikumar B Kunnumakkara[kunnumakkara@iitg.ac.in](kunnumakkara@iitg.ac.in)  \n1Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati 781039, Assam, India  \n2International Joint M. Tech Degree in Food Science and Technology, Department of Chemical Engineering, Indian Institute of Technology Guwahati (IITG), Guwahati 781039, Assam, India  \n3Electrical Engineering Department, College of Engineering, King Khalid University, Abha 61421, Saudi Arabia  \n4Research Centre, King Fahad Medical City, Riyadh 11525, Saudi Arabia 5Guangzhou Key Laboratory of Digestive Diseases, Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, China  \n6Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore  \n7NUS Centre for Cancer Research, Yong Loo Lin Scool of Medicine, National University of Singapore, Singapore 117699, Singapore 8Integrated Clinical Microecology Center, Shenzhen Hospital, Southern Medical University, Shenzhen 518000, China  \n9Department of Gastroenterology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images ","cbCaimkTweOlbHol","https://ap.wps.com/l/cbCaimkTweOlbHol","pdf",5201123,35,"English","# Abstract\n## Mechanistic role of gut dysbiosis in brain cancer progression\n## Microbial metabolites and tumour micro-environment regulation\n## Microbiota involvement in therapeutic efficiency","[{\"question\":\"How does gut dysbiosis relate to cognitive functioning?\",\"answer\":\"Dysbiosis in gut microbial composition disturbs homeostatic cognitive functioning through the reciprocal interaction between the gut microbiome and cognition.\"},{\"question\":\"Which brain cancer types are discussed in relation to dysbiosis?\",\"answer\":\"The review links gut dysbiosis with brain cancer, including glioma and glioblastoma, as part of dysbiosis-mediated progression.\"},{\"question\":\"What roles do gut microbial metabolites play in tumour progression?\",\"answer\":\"Microbial metabolites produced by gut microbiota, such as short-chain fatty acids, amino acids, and lipids, are described as regulatory factors influencing tumour progression.\"}]","Gut microbiota and their influence in brain cancer milieu | PDF",1790176980,88]