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Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastroenterol 2025 December 28; 31(48): 113178  \nDOI: 10.3748/wjg.v31.i48.113178 ISSN 1007-9327 (print) ISSN 2219-2840 (online)  \nLETTER TO THE EDITOR  \nGut microbiota: An overlooked target in dyslipidemia management  \nAmmara Abdul Majeed, Amna Subhan Butt  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade B, Grade B, Grade B, Grade C  \nNovelty: Grade B, Grade C, Grade C, Grade C  \nCreativity or Innovation: Grade B, Grade C, Grade C, Grade C Scientific Significance: Grade B, Grade C, Grade C, Grade C  \nP-Reviewer: Dubey V, Researcher, India; Racz A, MD, PhD, Full Professor, Croatia; Romanchuk OP, PhD, DM, Full Professor, Ukraine  \nReceived: August 18, 2025  \nRevised: October 1, 2025  \nAccepted: November 3, 2025  \nPublished online: December 28, 2025  \nProcessing time: 131 Days and 12.4 Hours  \nAmmara Abdul Majeed, Amna Subhan Butt, Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan  \nCorresponding author: Amna Subhan Butt, Associate Professor, Department of Medicine, Aga Khan University Hospital, Stadium Road, Karachi 74800, [Pakistan.](Pakistan. amna.subhan@aku.edu)[ amna.subhan@aku.edu](Pakistan. amna.subhan@aku.edu)  \nAbstract  \nWith the global rise in sedentary lifestyles, obesity, and unhealthy dietary patterns, dyslipidemia has emerged as a leading modifiable risk factor for atherosclerotic cardiovascular disease. Beyond host genetics and diet, the gut microbiota has gained recognition as a critical regulator of lipid homeostasis through mechanisms involving bile acid metabolism, short-chain fatty acid signaling, and microbial modulation of inflammation. Lv et al provide a comprehensive synthesis of the diet microbe-lipid axis and therapeutic strategies, including probiotics, prebiotics, and fecal microbiota transplantation. In this correspondence, we expand on their framework by highlighting underexplored yet clinically relevant dimensions, including circadian rhythm alignment, pharmacotherapy microbe crosstalk, population-specific microbial signatures, and functional microbial phenotyping. Addressing these overlooked aspects could accelerate the translation of microbiome science into precision dyslipidemia management, with the potential to improve cardiovascular outcomes worldwide.  \nKey Words: Dyslipidemia; Cardiovascular disease; Gut microbiome; Circadian rhythm; Precision medicine  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: Dyslipidemia has emerged as a leading modifiable risk factor for atherosclerotic, cardiovascular and hepatic diseases. Gut microbiota lipid metabolism interactions offer new opportunities for dyslipidemia management, but translating these insights into clinical practice requires more than compositional profiling. This letter emphasizes overlooked dimensions like circadian rhythm alignment, drug-microbe crosstalk, population-specific microbial patterns, and functional microbial signatures to guide precision, and context-aware strategies for cardiovascular risk reduction.  \n WJG  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 28, 2025  Volume 31  Issue 48   \nMajeed AA et al. Gut microbiota modulation in dyslipidemia  \nCitation: Majeed AA, Butt AS. Gut microbiota: An overlooked target in dyslipidemia management. World J Gastroenterol 2025;  \n31(48): 113178  \nURL: [https://www.wjgnet.com/1007-9327/full/v31/i48/113178.htm](https://www.wjgnet.com/1007-9327/full/v31/i48/113178.htm)  \nDOI: [https://dx.doi.org/10.3748/wjg.v31.i48.113178](https://dx.doi.org/10.3748/wjg.v31.i48.113178)  \nThe intricate interplay between gut microbiota (GM) and host lipid metabolism has emer","cbCaigwDRUJfY3Vq","https://ap.wps.com/l/cbCaigwDRUJfY3Vq","pdf",651565,"English","# Abstract\n# Core Tip\n# The intricate interplay between gut microbiota and lipid metabolism\n# Circadian rhythm and the GM axis\n# TRF, good sleep, and a healthy diet","[{\"question\":\"Why is gut microbiota considered an important target in dyslipidemia management?\",\"answer\":\"Gut microbiota regulates lipid homeostasis through bile acid metabolism, short-chain fatty acid signaling, and modulation of inflammation, which can influence dyslipidemia and atherosclerotic cardiovascular risk.\"},{\"question\":\"What additional dimensions does the letter highlight beyond diet microbe-lipid synthesis?\",\"answer\":\"It highlights overlooked, clinically relevant aspects including circadian rhythm alignment, pharmacotherapy–microbe crosstalk, population-specific microbial signatures, and functional microbial phenotyping.\"},{\"question\":\"How can circadian disruption affect dyslipidemia through the gut microbiota?\",\"answer\":\"Circadian misalignment can disturb microbial rhythmicity and promote dysbiosis, leading to altered triglyceride and very low-density lipoprotein levels, reduced high-density lipoprotein, and increased atherosclerotic risk.\"}]","Gut microbiota: An overlooked target in dyslipidemia management - Letter to the Editor | PDF",1790565388,18]