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Pathogenic bacteria such as Fusobacterium nucleatum and Helicobacter pylori promote tumorigenesis via genotoxicity, host metabolic reprogramming, and remodeling of the tumor immune microenvironment. Dysbiotic gut microbiome states also reduce responses to cancer therapeutics. This PRISMA-2020 systematic review analyzes molecular mechanisms linking gut microbiome to tumor development and discusses precision intervention strategies, including future multi-omics and AI-enabled monitoring and modulation.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/gut-microbiome-in-gastrointestinal-neoplasms-from-mechanisms-to-precision-therapeutic-strategies/366336/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/gut-microbiome-in-gastrointestinal-neoplasms-from-mechanisms-to-precision-therapeutic-strategies/366336.png","ImageObject",300,407,{"name":92,"@type":93},"Stanford","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",18,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What roles do gut pathogens like F. nucleatum and H. pylori play in gastrointestinal neoplasms?","Question",{"text":113,"@type":114},"They promote tumorigenesis through multiple mechanisms, including genotoxic damage, host metabolic reprogramming, and remodeling of the tumor immune microenvironment.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does a dysbiotic gut microbiome affect cancer treatment outcomes?",{"text":118,"@type":114},"A dysbiotic gut microbiome state compromises patient response rates to cancer therapeutics, particularly immunotherapy and other treatments mentioned in the review.",{"name":120,"@type":111,"acceptedAnswer":121},"What future directions does the review propose for microbiome-guided precision medicine?",{"text":122,"@type":114},"It outlines integrating multi-omics and artificial intelligence to enable dynamic monitoring and real-time modulation of microbial activity, supporting personalized microbiome-based precision medicine.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},366336,1790443952,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":31},2336477552062,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Song et al. Gut Pathogens (2025) 17:57 [https://doi.org/10.1186/s13099-025-00734-z](https://doi.org/10.1186/s13099-025-00734-z)  \nGut Pathogens  \n REVIEW Open Access  \nGut microbiome in gastrointestinal neoplasms: from mechanisms to precision therapeutic strategies  \nJiaqian Song1, Wei Zhang2* and Deqiang Wang3*  \nAbstract  \nBackground The incidence of Gastrointestinal Neoplasms (GI neoplasms) continues to increase globally. Colorectal cancer (CRC), in particular, has emerged as the second leading cause of cancer-related mortality worldwide. Now, Specific pathogenic bacteria, such as Fusobacterium nucleatum (F. nucleatum) and Helicobacter pylori (H. pylori), critically promote tumorigenesis through multiple mechanisms, including the induction of genotoxic damage,  \nhost metabolic reprogramming, and remodeling of the tumor immune microenvironment. Notably, a dysbiotic Gut Microbiome (GM) state significantly compromises patient response rates to cancer therapeutics. This review aims to systematically analyze the core molecular mechanism of GM affecting tumor development and explore the precise intervention strategies guided by clinical translation.  \nMethods This systematic review adhered to the PRISMA-2020 guidelines. We conducted a comprehensive literature search in PubMed (2008–2025) using key terms including“Gut Microbiome”,“Gastrointestinal Neoplasms”,“Fecal Microbiota Transplantation (FMT)”,“immunotherapy resistance”,“precision-based interventions”, and “emerging research frontiers”. Preclinical and clinical studies investigating the mechanisms, diagnostic applications, and therapeutic interventions of the GM in GI neoplasms were included.  \nResults This review systematically elucidates the tripartite mechanisms by which the GM influences the initiation and progression of GI neoplasms. And we innovatively proposed the“Proinflammation-metabolism-Immune framework (Dysbiosis of the GM jointly leads to the occurrence, development and metastasis of GI neoplasms by driving three interrelated processes: chronic inflammation (Proinflammation), reshaping the Metabolism of the host and TME(Metabolism), and inhibiting or altering the host Immune surveillance (Immune))”To deepen the understanding of host-microbe interactions. Based on this framework, we focused on discussing the therapeutic strategy targeting GM and confirmed its significant impact on the efficacy of anti-cancer treatment. Although these strategies have demonstrated clinical potential, current research is still mainly confined to preclinical models and the early clinical trial stage. To address this, we outline future directions: Integrating emerging technologies like multi-omics and artificial intelligence will enable dynamic monitoring and real-time modulation of microbial activity. This integration aims to establish a novel paradigm for microbiome-based personalized precision medicine.  \n*Correspondence: Wei Zhang [zw8839200@163.com](zw8839200@163.com)[ ](zw8839200@163.com)Deqiang Wang [deqiang_wang@aliyun.com](deqiang_wang@aliyun.com)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the pe","cbCainhuSwgxtbFY","https://ap.wps.com/l/cbCainhuSwgxtbFY","pdf",1853285,"English","# Abstract\n## Background\n## Methods\n## Results\n## Discussion\n# Introduction\n## Gut microbiome-host regulatory network and dysbiosis\n## Impact on therapy response","[{\"question\":\"What roles do gut pathogens like F. nucleatum and H. pylori play in gastrointestinal neoplasms?\",\"answer\":\"They promote tumorigenesis through multiple mechanisms, including genotoxic damage, host metabolic reprogramming, and remodeling of the tumor immune microenvironment.\"},{\"question\":\"How does a dysbiotic gut microbiome affect cancer treatment outcomes?\",\"answer\":\"A dysbiotic gut microbiome state compromises patient response rates to cancer therapeutics, particularly immunotherapy and other treatments mentioned in the review.\"},{\"question\":\"What future directions does the review propose for microbiome-guided precision medicine?\",\"answer\":\"It outlines integrating multi-omics and artificial intelligence to enable dynamic monitoring and real-time modulation of microbial activity, supporting personalized microbiome-based precision medicine.\"}]","Gut microbiome in gastrointestinal neoplasms: from mechanisms to precision therapeutic strategies | PDF",1790164876]