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This systematic review and meta-analysis searched public databases through June 2023 and evaluated taxonomic and functional features of gut microbiota in CP, PDAC, and controls. Fourteen studies (n=1511) showed reduced α-diversity and altered β-diversity in patients versus healthy controls, with phylum- and genus-level shifts and functional/metabolomic differences. No significant microbiota differences were found between PDAC and CP specifically.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/gut-microbiome-changes-associated-with-chronic-pancreatitis-and-pancreatic-cancer-a-systematic-review-and-meta-analysis-read-online/340052/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/gut-microbiome-changes-associated-with-chronic-pancreatitis-and-pancreatic-cancer-a-systematic-review-and-meta-analysis-read-online/340052.png","ImageObject",300,407,{"name":92,"@type":93},"Miles","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",16,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the goal of this systematic review and meta-analysis?","Question",{"text":113,"@type":114},"To analyze taxonomic and functional characteristics of the gut microbiome in patients with chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC). The study also considered implications for noninvasive diagnostics and interventions.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How many studies and participants were included, and what main diversity differences were found?",{"text":118,"@type":114},"The meta-analysis included 14 studies with 1511 individuals total across PDAC (n=285), CP (n=342), and control (n=649) groups. Patients showed a slight decrease in α-diversity (Shannon) and statistically significant differences in β-diversity versus healthy controls.",{"name":120,"@type":111,"acceptedAnswer":121},"Did the gut microbiome differ between PDAC patients and CP patients?",{"text":122,"@type":114},"No. The study found no significant differences in gut microbiota between PDAC and CP patients.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},340052,1790501411,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},13056703019404,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","’Systematic Review and/or Meta-analysis  \nGut microbiome changes associated with chronic pancreatitis and pancreatic cancer: a systematic review and meta-analysis  \nJiaze Hong, MD, Yufan Fu, MD, PhD, Xiaoqian Chen, MD, PhD, YuruiZhang, MD, PhD, Xinyi Li, MD, Tianhang Li, MD, Yilin Liu, MD, Mengke Fan, MD, PhD*, Rong Lin, MD, PhD*  \nBackground: The study of changes in the microbiome in chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) holds significant potential for developing noninvasive diagnostic tools as well as innovative interventions to alter the progression of diseases. This systematic review and meta-analysis aimed to analyze in detail the taxonomic and functional characteristics of the gut microbiome in patients with CP and PDAC.  \nMethods: Two researchers conducted a systematic search across public databases to gather all published research up to June 2023. Diversity and gut microbiota composition are the main outcomes the authors focus on.  \nResults: This meta-analysis included 14 studies, involving a total of 1511 individuals in the PDAC (n = 285), CP (n = 342), and control (n = 649) groups. Our results show a significant difference in the composition of gut microbiota between PDAC/CP patients compared to healthy controls (HC), as evidenced by a slight decrease in α-diversity, including Shannon (SMD = −0 .33; P = 0.002 and SMD = −0.59; P \u003C 0.001, respectively) and a statistically significant β-diversity (P \u003C 0.05) . The pooled results showed that at the phylum level, the proportion of Firmicutes was lower in PDAC and CP patients than in HC patients. At the genus level, more than two studies demonstrated that four genera were significantly increased in PDAC patients compared to HC (e.g. Escherichia-Shigella and Veillonella) . CP patients had an increase in four genera (e.g. Escherichia-Shigella and Klebsiella) and a decrease in eight genera (e.g. Coprococcus and Bifidobacterium) compared to HC. Functional/metabolomics results from various studies also showed differences between PDAC/CP patients and HC. In addition, this study found no significant differences in gut microbiota between PDAC and CP patients.  \nConclusions: Current evidence suggests changes in gut microbiota is associated with PDAC/CP, commonly reflected by a reduction in beneficial species and an increase in the pathogenic species. Further studies are needed to confirm these findings and explore therapeutic possibilities.  \nKeywords: chronic pancreatitis, gut microbiome, meta-analysis, pancreatic cancer  \nIntroduction  \nThe human microbiota is a leading field of dynamic research in our time, with a predominant focus on the distal gastrointestinal tract, which harbors most of our microbes[1]. The human gut is home to avast community of 100 trillion microorganisms encompassing more than1000distinct resident bacterial species[2]. In the digestive tract, the  \npredominant bacteria are Firmicutes and Bacteroidetes, which account for ~80–90% of the population[3]. Human physiology is significantly impacted by the gut microbiota, as it influences metabolism, regulates the immune system of mucosal tissues, aids in digestion, and maintains intestinal architecture[4]. Dysbiosis of the gut microbiota is linked to various illnesses, including localized gastrointestinal disorders and metabolic, respiratory, hepatic, and neurological disorders[5].  \nDepartment of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China Jiaze Hong and Yufan Fu have shared the co-first author.  \nRong Lin and Mengke Fan have shared the co-corresponding author.  \nSponsorships or competing interests that may be relevant to content are disclosed at the end of this article.  \n*Corresponding author. Address: Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, People’s Republic of China. Tel.: +86 156 2918 0035; fax: +8","cbCainuThbnhCE1A","https://ap.wps.com/l/cbCainuThbnhCE1A","pdf",903633,14,"English","# Background\n# Methods\n# Results\n## Diversity and composition outcomes\n## Taxonomic and functional findings\n# Conclusions\n# Keywords","[{\"question\":\"What was the goal of this systematic review and meta-analysis?\",\"answer\":\"To analyze taxonomic and functional characteristics of the gut microbiome in patients with chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC). The study also considered implications for noninvasive diagnostics and interventions.\"},{\"question\":\"How many studies and participants were included, and what main diversity differences were found?\",\"answer\":\"The meta-analysis included 14 studies with 1511 individuals total across PDAC (n=285), CP (n=342), and control (n=649) groups. Patients showed a slight decrease in α-diversity (Shannon) and statistically significant differences in β-diversity versus healthy controls.\"},{\"question\":\"Did the gut microbiome differ between PDAC patients and CP patients?\",\"answer\":\"No. The study found no significant differences in gut microbiota between PDAC and CP patients.\"}]","Gut microbiome changes associated with chronic pancreatitis and pancreatic cancer - a systematic review and meta-analysis - read online | PDF",1790033932,35]