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Although the mechanisms linking microbiota to renal cell carcinoma (RCC) remain unresolved, dysbiosis is proposed as one contributing pathway. This review summarizes gut-driven mechanisms for RCC, evaluates evidence implicating urinary microbiota, and examines how gut microbiota may affect RCC treatment. It further discusses microbiota composition as a potential predictive marker for immune checkpoint inhibitors and considers microbiota modulation as an adjuvant strategy to improve drug responses.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/gut-and-urinary-microbiota-the-causes-and-potential-treatment-measures-of-renal-cell-carcinoma/382575/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/gut-and-urinary-microbiota-the-causes-and-potential-treatment-measures-of-renal-cell-carcinoma/382575.png","ImageObject",300,407,{"name":92,"@type":93},"Kyle","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main focus of this review on renal cell carcinoma?","Question",{"text":112,"@type":113},"It reviews how gut microbiota may contribute to RCC development, evaluates evidence for urinary microbiota involvement, and discusses microbiota-related roles in RCC treatment, including prediction of immune checkpoint inhibitor efficacy.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why is dysbiosis considered relevant to RCC?",{"text":117,"@type":113},"Dysbiosis is proposed as a possible mechanism by which microbiota may contribute to RCC development and treatment, even though the precise involvement of microbiota in RCC biology is not yet fully clear.",{"name":119,"@type":110,"acceptedAnswer":120},"How might gut microbiota influence immune checkpoint inhibitor therapy in RCC?",{"text":121,"@type":113},"The review proposes that gut microbiota composition could serve as a predictive marker for potential efficacy of immune checkpoint inhibitors in RCC patients.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},382575,1790583445,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},3985741905716,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","TYPE Review  \nPUBLISHED 27 June 2023  \nDOI 10.3389/fimmu.2023.1188520  \nOPEN ACCESS  \nEDITED BY  \nJianzhong Ai,  \nSichuan University, China  \nREVIEWED BY  \nH. Atakan Ekiz,  \nIzmir Institute of Technology, Türkiye Attayeb Mohsen,  \nNational Institutes of Biomedical Innovation, Health and Nutrition, Japan  \n*CORRESPONDENCE Li Yang  \n [ery_yangli@lzu.edu.cn](ery_yangli@lzu.edu.cn)  \n†These authors have contributed equally to this work  \nRECEIVED 17 March 2023  \nACCEPTED 12 June 2023  \nPUBLISHED 27 June 2023  \nCITATION  \nYang J-w, Wan S, Li K-p, Chen S-Y and Yang L (2023) Gut and urinary microbiota:  \nthe causes and potential treatment measures of renal cell carcinoma.  \nFront. Immunol. 14:1188520 .  \ndoi: 10.3389/fimmu.2023.1188520  \nCOPYRIGHT  \n© 2023 Yang, Wan, Li, Chen and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nGut and urinary microbiota: the causes and potential treatment measures of renal cell carcinoma  \nJian-wei Yang †, Shun Wan †, Kun-peng Li †, Si-Yu Chen and Li Yang*  \nDepartment of Urology, The Second Hospital of Lanzhou University, Lanzhou, China  \nMounting evidence suggests that the gut microbiota plays a crucial role in the development and treatment of various cancers. Recent research on the urinary microbiota challenges the long-standing belief that urine is sterile, as urinary microbiota has been implicated in the development of bladder and prostate cancers, similar to the role of gut microbiota in cancer development. Although the precise involvement of microbiota in the proliferation and differentiation of renal cell carcinoma (RCC) remains unclear, dysbiosis is considered one possible mechanism by which microbiota may contribute to RCC development and treatment. This review summarizes potential mechanisms by which gut microbiota may contribute to the development of RCC, and provides evidence for the involvement of urinary microbiota in RCC. We also explore the role of gut microbiota in RCC treatment and propose that the composition of gut microbiota could serve as a predictive marker for the potential efficacy of immune checkpoint inhibitors (ICIs) in RCC patients. Additionally, evidence suggests that modulating the abundance and distribution of microbiota can enhance the therapeutic effects of drugs, suggesting that microbiota may serve as a promising adjuvant therapy for RCC. Overall, we believe that further investigation into the gut and urinary microbiome of RCC patients could yield valuable insights and strategies for the prevention and personalized treatment of RCC.  \nKEYWORDS  \nrenal cell carcinoma, microbiome, immunotherapy, targeted therapy, gut microbiota, urinary microbiota, fecal microbiota transplantation, biomarker  \n1 Introduction  \nRenal cell carcinoma (RCC) is a solid tumor that originates in the renal parenchyma and is resistant to chemotherapy. According to cancer statistics from 2017, RCC accounted for 4.1% of all newly diagnosed cancers, and its incidence has been on the rise (1) . Currently, RCC is the sixth most common cancer in men and the tenth most common cancer in women. Moreover, up to 17% of patients are found to have distant metastasis atthe time of diagnosis (2, 3) .  \nFrontiers in Immunology 01 [frontiersin.org](frontiersin.org)  \nMicrobiota is a normal component of the human body’s ecology, with approximately 4×1013 bacterial microorganisms and up to 3×103 species. Nearly 97% of these microorganisms reside in the colon and participate in normal human physiological processes, but they may also contribute to some pathological reactions (4) . Atthe same time, numerous stud","cbCaia3n00BqTOhK","https://ap.wps.com/l/cbCaia3n00BqTOhK","pdf",1085653,"English","# Introduction\n# Description of microbial detection technologies\n## Next-generation sequencing (NGS)\n## Shotgun whole-genome sequencing (WGS)\n## 16S rRNA amplicon sequencing","[{\"question\":\"What is the main focus of this review on renal cell carcinoma?\",\"answer\":\"It reviews how gut microbiota may contribute to RCC development, evaluates evidence for urinary microbiota involvement, and discusses microbiota-related roles in RCC treatment, including prediction of immune checkpoint inhibitor efficacy.\"},{\"question\":\"Why is dysbiosis considered relevant to RCC?\",\"answer\":\"Dysbiosis is proposed as a possible mechanism by which microbiota may contribute to RCC development and treatment, even though the precise involvement of microbiota in RCC biology is not yet fully clear.\"},{\"question\":\"How might gut microbiota influence immune checkpoint inhibitor therapy in RCC?\",\"answer\":\"The review proposes that gut microbiota composition could serve as a predictive marker for potential efficacy of immune checkpoint inhibitors in RCC patients.\"}]","Gut and urinary microbiota: the causes and potential treatment measures of renal cell carcinoma | PDF",1790251110,25]