[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332591-105":59,"doc-detail-332591-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","gut-and-oral-microbiota-in-gynecological-cancers-interaction-mechanism-and-therapeutic-value","Gut and oral microbiota in gynecological cancers: interaction, mechanism, and therapeutic value","","Gut and oral microbiota are implicated in the development and worsening of gynecologic cancers through bidirectional communication that can drive mucosal destruction, inflammatory signaling, genomic instability, and cancer progression. The review outlines mechanistic crosstalk between gut and oral microbial communities and summarizes how shifts in microbiome composition relate to tumor development. It also discusses emerging therapeutic strategies that target microbiota modulation to improve outcomes and enhance responses to cancer treatment.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/gut-and-oral-microbiota-in-gynecological-cancers-interaction-mechanism-and-therapeutic-value/332591/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/gut-and-oral-microbiota-in-gynecological-cancers-interaction-mechanism-and-therapeutic-value/332591.png","ImageObject",300,407,{"name":92,"@type":93},"Rowan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How do gut and oral microbiota interact in gynecological cancer development?","Question",{"text":112,"@type":113},"They can communicate through multiple routes, contributing to mucosal damage, inflammatory responses, and genomic instability that promote tumor progression and worsening.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What role does the microbiome play beyond being a passive observer?",{"text":117,"@type":113},"The microbiome actively affects immune, metabolic, and endocrine systems, which can influence host physiology and cancer-related processes.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is microbiota modulation considered a therapeutic strategy?",{"text":121,"@type":113},"By targeting microbiome composition and function, new approaches aim to influence cancer development mechanisms and potentially improve responses to chemotherapy, radiation therapy, and immunotherapy.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332591,1790129879,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1099514067415,"https://ap-avatar.wpscdn.com/avatar/100002539d78ffe74a7?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779092875211072502","npj | biofilms and microbiomes Review article  \n\n| Published in partnership with Nanyang Technological University |  | |\n| --- | --- | --- |\n| [https://doi.org/10.1038/s41522-024-00577-7](https://doi.org/10.1038/s41522-024-00577-7) |  |  |\n| Gut and oral microbiota in gynecological cancers: interaction, mechanism, and therapeutic value\u003Cbr> Check for updates |  |  |\n| Jian Wu 1,3 , Jiarui Li2,3, Meina Yan1 & Ze Xiang2  |  |  |\n| Gynecologic cancers develop from the female reproductive organs. Microbial dysbiosis in the gut and oral cavity can communicate with each other through various ways, leading to mucosal destruction, inflammatory response, genomic instability, and ultimately inducing cancer and worsening. Here, we introduce the mechanisms of interactions between gut and oral microbiota and their changes in the development of gynecologic tumors. In addition, new therapeutic approaches based on microbiota modulation are discussed. |  |  |\n| Cancer is one of the leading causes of premature death all around the world and a huge threat to public health1. Due to the strong influence of demographic changes such as population aging and growth on different trends in cancer incidence in different regions, the number of cancer patients worldwide is expected to double in the next 50 years2. National cancer incidence rates from the GLOBOCAN database ofthe International Agency for Research on Cancer within the Global Cancer Observatory estimate that the six most commonly diagnosed cancers worldwide are currently: stomach, colorectal, lung, breast, cervical and prostate cancers1, among which cervical cancer (CC) is the most common type of gynecological cancer. In addition, gynecological cancers also include endometrial cancer (EC) and ovarian cancer (OC) commonly, vaginal cancer and vulvar cancer rarely3.\u003Cbr>Different part of the human body (gut, skin, lungs, oral cavity) is colonized by a variety ofcommensal, symbiotic and pathogenic microbiota, including bacteria, archaea, fungi, protists, and viruses4,5. Additionally, the human microbiota, commonly referred to as “the hidden organ,” contributes more genetic data than the total human genome by a factor of over 1506. The community of microbes in a particular environment is called microbiota, while the microbes, their genomes, and the surrounding environment are called microbiome7. In the past two decades, due to the rapid development ofthe technology of cultivating independent genomes, alot of related research has been carried out, and studies such as the Human Microbiome Project (HMP) provide insights into the composition of atypical healthy microbiome8. Recent advances in microbiome research have demonstrated that the microbiome is not just a passive bystander, but plays an important role in altering the immune, metabolic and endocrine systems, which in turn affects the physiological functions of the host9–11. More importantly, microbes have shown a complex relationship with cancer development. Although cancer is generally considered to be caused by a | combination ofhost genetic and environmental factors, microbes have been implicated in ~20% of human malignancies12.\u003Cbr>As one of HMP’s five research priorities (oral cavity, nasal, vaginal, intestinal, skin), the gut microbiome is considered the most important microbiome for maintaining human health. It is estimated that the human gastrointestinal tract harbors as many as 100 trillion microbes, with 200–1000 species of bacteria, numbering around 40 trillion13. The exact number of bacterial species shared within the digestive system or among individuals remains undetermined. For instance, a study of 124 European individuals revealed a total of approximately 1150 bacterial species, with most individuals harboring around 160 species14. Another study identified 632 bacterial species in a cohort of 1135 Dutch individuals15; and at least 1235 species-level phylotypes (SLPs) were found in the gut microbiota of 120Chinese individuals16. Bacteria ","cbCaiaUF5uFOsJb3","https://ap.wps.com/l/cbCaiaUF5uFOsJb3","pdf",1132448,13,"English","# Background and significance\n## Global cancer burden and gynecologic cancer scope\n## Microbiota and microbiome concepts\n# Microbiome roles in cancer development\n## How microbes influence immunity, metabolism, and endocrine systems\n## Microbes in malignancies and cancer mechanisms\n# Gut microbiome in detail\n## Composition, enterotypes, and functional variation\n## Microbial crosstalk and effects on tumor biology\n## Modulation of therapy response\n# Oral microbiome in detail\n## Oral microbial diversity and ecological stability\n## Links between periodontal microbes and cancer\n# Interaction pathways and therapeutic value","[{\"question\":\"How do gut and oral microbiota interact in gynecological cancer development?\",\"answer\":\"They can communicate through multiple routes, contributing to mucosal damage, inflammatory responses, and genomic instability that promote tumor progression and worsening.\"},{\"question\":\"What role does the microbiome play beyond being a passive observer?\",\"answer\":\"The microbiome actively affects immune, metabolic, and endocrine systems, which can influence host physiology and cancer-related processes.\"},{\"question\":\"Why is microbiota modulation considered a therapeutic strategy?\",\"answer\":\"By targeting microbiome composition and function, new approaches aim to influence cancer development mechanisms and potentially improve responses to chemotherapy, radiation therapy, and immunotherapy.\"}]","Gut and oral microbiota in gynecological cancers: interaction, mechanism, and therapeutic value | PDF",1789998849,33]