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This case report describes a 34-year-old pregnant woman who developed bilateral limb weakness at 36 weeks of gestation and was diagnosed with GBS after multidisciplinary evaluation. She received intravenous immunoglobulin (IVIG) and high-dose corticosteroids, with subsequent clinical improvement. The report highlights the dynamic obstetric progression of GBS and the importance of early recognition and coordinated care for maternal and neonatal outcomes.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/guillain-barre-syndrome-in-the-third-trimester-of-pregnancy-a-case-report-and-literature-review/460095/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/guillain-barre-syndrome-in-the-third-trimester-of-pregnancy-a-case-report-and-literature-review/460095.png","ImageObject",300,407,{"name":92,"@type":93},"Blitz","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the key clinical hallmark of Guillain-Barré syndrome in this report?","Question",{"text":112,"@type":113},"The report describes rapidly progressive muscle weakness with areflexia (diminished deep tendon reflexes).","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was GBS suspected and confirmed in the patient?",{"text":117,"@type":113},"GBS was suspected based on progressive limb weakness, dyspnea, examination findings of decreased muscle strength and diminished reflexes with preserved sensation, and electromyography showing partial motor conduction block.",{"name":119,"@type":110,"acceptedAnswer":120},"What treatment was given, and what was the outcome?",{"text":121,"@type":113},"The patient was treated with intravenous immunoglobulin (IVIG) and high-dose corticosteroids, leading to significant clinical improvement and discharge for continued rehabilitation.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},460095,1790773211,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},24464137899374,"https://us-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","e-ISSN 1941-5923  \n© Am J Case Rep, 2025; 26: e949852 DOI: 10. 12659/AJCR.949852  \nReceived: 2025.05.16  \nAccepted: 2025.11.05  \nAvailable online: 2025.11.17  \nPublished: 2025.12.25  \nAuthors’ Contribution: Study Design A  \nData Collection B Statistical Analysis C Data Interpretation D Manuscript Preparation E Literature Search F Funds Collection G  \nABCDEF BF  \nADE  \nCorresponding Author: Financial support: Conflict of interest:  \nGuillain-Barré Syndrome in the Third Trimester of Pregnancy: A Case Report and Literature Review  \nLiang Gao Mouchang Qiu Hua Qian  \nDepartment of Obstetrics and Gynecology, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, Jiangsu, PR China  \nHua Qian, e-mail: [qhtzrmyy@163.com](qhtzrmyy@163.com)  \nNone declared  \nNone declared  \nPatient: Female, 34-year-old  \nFinal Diagnosis: Guillain-Barré syndrome (GBS)  \nSymptoms: Bilateral limb weakness  \nClinical Procedure: —  \nSpecialty: Neurology • Obstetrics and Gynecology  \nObjective: Rare disease  \nBackground: Guillain-Barré syndrome (GBS) is a rare autoimmune peripheral neuropathy. Its hallmark features include rapidly progressive muscle weakness and areflexia. This report describes a 34-year-old woman in the third trimester of pregnancy who presented with limb weakness and was diagnosed with GBS. The patient underwent treatment with intravenous immunoglobulin (IVIG) and high-dose corticosteroid therapy.  \nCase Report: A 34-year-old pregnant woman developed bilateral limb weakness at 36 weeks of gestation. Upon hospital admission and clinical evaluation, multidisciplinary consultation was conducted. Considering her history of diarrhea 1 week earlier, the presence of dyspnea, bilateral limb muscle weakness, physical examination findings of decreased muscle strength and diminished deep tendon reflexes with preserved limb sensation, GBS was suspected as the primary diagnosis. As her condition continued to deteriorate, she underwent an emergency cesarean delivery under spinal anesthesia. Postoperatively, her muscle weakness progressively worsened. IVIG and high-dose corticosteroid therapy was initiated, resulting in significant clinical improvement. Both mother and infant were subsequently discharged to a local hospital for continued rehabilitation.  \nConclusions: This case underscores the dynamic progression of GBS, particularly in obstetric populations, and emphasizes the critical role of early recognition and multidisciplinary collaboration in optimizing maternal and neonatal outcomes. The report aims to enhance clinical awareness, improve diagnostic accuracy, and inform therapeutic strategies for similar cases.  \nKeywords: Guillain-Barré Syndrome (GBS)• Pregnancy • Intravenous Immunoglobulin (IVIG)• Limb Weakness  \nFull-text PDF: [https://www.amjcaserep.com/abstract/index/idArt/949852](https://www.amjcaserep.com/abstract/index/idArt/949852)  \n1976  1  —  30  \nPublisher’s note: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher  \nThis work is licensed under Creative Common AttributionNonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)  \ne949852-1  \nIndexed in: [PMC] [PubMed] [Emerging Sources Citation Index (ESCI)][Web of Science by Clarivate]  \nGao [L. et](L. et) al: Guillain-Barré syndrome in pregnancy © Am J Case Rep, 2025; 26: e949852  \nIntroduction  \nGuillain-Barré syndrome (GBS) is an acute or subacute peripheral nerve disorder caused by the immune system abnormally damaging nerve myelin sheaths or axons [1]. Viral infections serve as significant triggers for GBS [2]. GBS typically manifestsas symmetric weakness and sensory abnormalities in the distal lower limbs. As the condition progresses, respiratory muscle weakn","cbCainFLh7mLAbdb","https://ap.wps.com/l/cbCainFLh7mLAbdb","pdf",167009,"English","# Introduction\n# Case Report\n# Conclusions","[{\"question\":\"What is the key clinical hallmark of Guillain-Barré syndrome in this report?\",\"answer\":\"The report describes rapidly progressive muscle weakness with areflexia (diminished deep tendon reflexes).\"},{\"question\":\"How was GBS suspected and confirmed in the patient?\",\"answer\":\"GBS was suspected based on progressive limb weakness, dyspnea, examination findings of decreased muscle strength and diminished reflexes with preserved sensation, and electromyography showing partial motor conduction block.\"},{\"question\":\"What treatment was given, and what was the outcome?\",\"answer\":\"The patient was treated with intravenous immunoglobulin (IVIG) and high-dose corticosteroids, leading to significant clinical improvement and discharge for continued rehabilitation.\"}]","Guillain-Barré Syndrome in the Third Trimester of Pregnancy - A Case Report and Literature Review | PDF",1790757723,13]