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The work applies fermentative granulation to valorize solid-free thin stillage using a high-rate chain elongation process without exogenous electron-donating intermediates. An expanded granular sludge bed reactor produced caproic acid at sustained rates, achieving high COD-to-caproic acid conversion with lactic acid serving as the electron donor.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/granular-fermentation-enables-high-rate-caproic-acid-production-accepted-manuscript/606617/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/granular-fermentation-enables-high-rate-caproic-acid-production-accepted-manuscript/606617.png","ImageObject",300,407,{"name":92,"@type":93},"Stanley","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-10-16",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What problem does the paper address in chain elongation processes?","Question",{"text":112,"@type":113},"It addresses low volumetric production rates that have hindered applying microbial chain elongation to valorize (agro)industrial wastes or sidestreams.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is caproic acid produced in this study?",{"text":117,"@type":113},"Through a fermentative expanded granular sludge bed reactor that applies fermentative granulation to solid-free thin stillage for high-rate chain elongation.",{"name":119,"@type":110,"acceptedAnswer":120},"What role does lactic acid play in the process?",{"text":121,"@type":113},"Lactic acid serves as the electron donating intermediate; no net ethanol was consumed during the stable operation period.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},606617,1792231190,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},2336477405376,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Green Chemistry  \nAccepted Manuscript  \nView Article Online  \nView Journal  \nThis article can be cited before page numbers have been issued, to do this please use: J. M. CarvajalArroyo, P. Candry, S. J. Andersen, R. Props, T. W. Seviour, R. Ganigué and K. Rabaey, Green Chem., 2019, DOI: 10. 1039/C8GC03648A.  \nVolume 18  \nNumber 7  \n7 April 2016  \nPages 1821–2242  \nGreen Chemistry  \nCutting-edge research for a greener sustainable future [www.rsc.org/greenchem](www.rsc.org/greenchem)  \nISSN 1463-9262  \nThis is an Accepted Manuscript, which has been through the Royal Society of Chemistry peer review process and has been accepted for publication.  \nAccepted Manuscripts are published online shortly after acceptance, before technical editing, formatting and proof reading. Using this free service, authors can make their results available to the community, in citable form, before we publish the edited article. We will replace this Accepted Manuscript with the edited and formatted Advance Article as soon as it is available.  \nYou can find more information about Accepted Manuscripts in the author guidelines.  \nPlease note that technical editing may introduce minor changes to the text and/or graphics, which may alter content. The journal’s standard Terms & Conditions and the ethical guidelines, outlined in our author and reviewer resource centre, still apply. In no event shall the Royal Society of Chemistry be held responsible for any errors or omissions in this Accepted Manuscript or any consequences arising from the use of any information it contains.  \n[rsc.li/green-chem](rsc.li/green-chem)  \nPage 1 of 30  \nPublished on 19 February 2019. Downloaded on 2/20/20 19 5:35:26 AM .  \n1  \n2  \n3  \n4  \n5  \n6  \n7  \n8  \n9  \n10  \n11  \n12  \n13  \n14  \n15  \n16  \n17  \nGreen Chemistry  \nGranular fermentation enables high rate caproic acid production  \nfrom solid-free thinDOsI:t1il0l1a0eiwCArticle8GC03On64lin8eA  \nJosé María Carvajal-Arroyoa, Pieter Candrya, Stephen J. Andersena, Ruben Propsa, Thomas Seviourb, Ramon Ganigué and Korneel Rabaeya,*  \naCenter for Microbial Ecology and Technology (CMET), Department of Biotechnology, Ghent University, Coupure Links 653, B-9000 Gent, Belgium  \nbSingapore Centre of Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, 60 Nanyang Drive, SBS-01N-27, Singapore 637551.  \nResearch article to be submitted to Green Chemistry  \n*Corresponding author  \nKorneel Rabaey, Ghent University; Faculty of Bioscience Engineering; Center for Microbial Ecology and Technology (CMET); Coupure Links 653; B-9000 Gent, Belgium; phone: +32 (0)9 264 59 76; fax: +32 (0)9 264 62 48; [E-mail: ](E-mail: Korneel.Rabaey@ugent.be)[Korneel.Rabaey@ugent.be](E-mail: Korneel.Rabaey@ugent.be) ; [Webpage: ](Webpage: www.cmet.ugent.be)[www.cmet.ugent.be](Webpage: www.cmet.ugent.be).  \nGreen Chemistry Accepted Manuscript  \nGreen Chemistry Page 2 of 30  \nPublished on 19 February 2019. Downloaded on 2/20/20 19 5:35:26 AM .  \n18 Abstract View Article Online DOI: 10. 1039/C8GC03648A  \n19 Microbial chain elongation has been investigated as a process to upgrade diluted ethanol to more  \n20 valuable medium chain carboxylic acids. However, its application in the valorization of (agro)industrial  \n21 wastes or sidestreams has been hampered by low volumetric production rates. Microbial granulation, 22 widely applied in wastewater treatment, has been rarely explored in a context of bioproduction. Here  \n23 we show how fermentative granulation can be applied to the valorization of solid-free thin stillage, 24 through a high-rate chain elongation process for the production of MCCA without the addition of  \n25 exogenous electron donating intermediates. Using a fermentative expanded granular sludge bed reactor, 26 caproic acid was produced at sustained rates of 12.3 gC6 L-1 d-1 (625 mmol C L-1 d-1 or 27.2 g C6-COD  \n27 L-1 d-1) at pH 5.5, and concentrations of up to 6.8 g C6 L-1 . During a stable period (days 181-217) the  \n28 27.2% ofthe","cbCailoJK7w6072U","https://ap.wps.com/l/cbCailoJK7w6072U","pdf",1305180,31,"English","# Abstract\n## Introduction\n## Keywords","[{\"question\":\"What problem does the paper address in chain elongation processes?\",\"answer\":\"It addresses low volumetric production rates that have hindered applying microbial chain elongation to valorize (agro)industrial wastes or sidestreams.\"},{\"question\":\"How is caproic acid produced in this study?\",\"answer\":\"Through a fermentative expanded granular sludge bed reactor that applies fermentative granulation to solid-free thin stillage for high-rate chain elongation.\"},{\"question\":\"What role does lactic acid play in the process?\",\"answer\":\"Lactic acid serves as the electron donating intermediate; no net ethanol was consumed during the stable operation period.\"}]","Granular fermentation enables high rate caproic acid production - Accepted Manuscript | PDF",1792185275,78]