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Immunohistochemistry of patient samples measures GLO1 expression, while HeLa cell studies test how pharmacologic GLO1 inhibition affects viability and migration. Single-cell RNA sequencing, gene set variation analysis, and public microarray datasets assess GLO1-linked metabolism across cancer stages. GLO1 is consistently upregulated and associates with glycolysis.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/glyoxalase-1-emerging-biomarker-and-therapeutic-target-in-cervical-cancer-progression/332145/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/glyoxalase-1-emerging-biomarker-and-therapeutic-target-in-cervical-cancer-progression/332145.png","ImageObject",300,407,{"name":92,"@type":93},"Hazel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main biological focus of the study?","Question",{"text":112,"@type":113},"The study focuses on Glyoxalase-1 (GLO1) and its role in methylglyoxal detoxification in cervical cancer progression.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was GLO1 expression assessed in patient samples?",{"text":117,"@type":113},"GLO1 expression was assessed in cervical cancer patient samples using immunohistochemistry.",{"name":119,"@type":110,"acceptedAnswer":120},"What effects did GLO1 inhibition have in vitro?",{"text":121,"@type":113},"GLO1 inhibition decreased cell viability and migration in cervical cancer cell lines, including HeLa-based in vitro experiments.",{"name":123,"@type":110,"acceptedAnswer":124},"What do the analyses suggest about GLO1 and cancer metabolism?",{"text":125,"@type":113},"Single-cell RNA sequencing and public gene expression datasets support GLO1 overexpression and its involvement in cancer metabolism, particularly glycolysis, with a progressive increase across disease stages.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},332145,1790549529,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":143,"language":144,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":67,"update_tm":148,"read_time":149,"preview_page_count":4},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","PLOS ONE  \nOPEN ACCESS  \nCitation: Kim J-Y, Jung J-H, Jung S, Lee S, Lee HA, Ouh Y-T, et al. (2024) Glyoxalase 1: Emerging biomarker and therapeutic target in cervical cancer progression. PLoS ONE 19(6): e0299345 . [https://](https://)[ ](https://)[doi.org/10.1371/journal.pone.0299345](doi.org/10.1371/journal.pone.0299345)  \n[Editor:](Editor: Faramarz Dehghani)[ Faramarz Dehghani](Editor: Faramarz Dehghani), Martin Luther University, GERMANY  \nReceived: February 28, 2024  \nAccepted: May 26, 2024  \nPublished: June 13, 2024  \nCopyright: © 2024 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nData Availability Statement: All relevant data are within the manuscript and its Supporting Information files.  \nFunding: This study was supported by the National Research Foundation of Korea (NRF) grant funded by Korea (RS-2023-00279214) . This study was also supported by the Analytic Biological Service Project (ABSP), funded by the Kangwon National University Hospital Grant in 2021 and 2022.  \nCompeting interests: No potential conflict of interest relevant to this article was reported.  \nRESEARCH ARTICLE  \nGlyoxalase 1: Emerging biomarker and therapeutic target in cervical cancer progression  \nJi-Young Kim1, Ji-Hye Jung1, Soryung Jung2, Sanghyuk Lee2, Hyang Ah Lee3, YungTaekOuh3,4 *, Seok-Ho Hong1,5 *  \n1 Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea, 2 Department of Life Science, Ewha Womans University, Seoul, Republic of Korea, 3 Department of Obstetrics and Gynecology, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea, 4 Department of Obstetrics and Gynecology, Ansan Hospital, Korea University College of Medicine, Gyeonggi, Republic of Korea, 5 KW-Bio Co. , Ltd, Chuncheon, Republic of Korea  \n* [oytjjang@gmail.com](oytjjang@gmail.com) (Y-TO); [shhong@kangwon.ac.kr](shhong@kangwon.ac.kr) (S-HH)  \nAbstract  \nIntroduction  \nCervical cancer presents a significant global health challenge, disproportionately impacting underserved populations with limited access to healthcare. Early detection and effective management are vital in addressing this public health concern. This study focuses on Glyoxalase-1 (GLO1), an enzyme crucial for methylglyoxal detoxification, in the context of cervical cancer.  \nMethods  \nWe assessed GLO1 expression in cervical cancer patient samples using immunohistochemistry. In vitro experiments using HeLa cells were conducted to evaluate the impact of GLO1 inhibition on cell viability and migration. Single-cell RNA sequencing (scRNA-seq) and gene set variation analysis were utilized to investigate the role of GLO1 in the metabolism of cervical cancer. Additionally, public microarray data were analyzed to determine GLO1 expression across various stages of cervical cancer.  \nResults  \nOur analysis included 58 cervical cancer patients, and showed that GLO1 is significantly upregulated in cervical cancer tissues compared to normal cervical tissues, independent of pathological findings and disease stage. In vitro experiments indicated that GLO1 inhibition by S-p-bromobenzylglutathione cyclopentyl diester decreased cell viability and migration in cervical cancer cell lines. Analyses of scRNA-seq data and public gene expression datasets corroborated the overexpression of GLO1 and its involvement in cancer metabolism, particularly glycolysis. An examination of expression data from precancerous lesions revealed a progressive increase in GLO1 expression from normal tissue to invasive cervical cancer.  \nConclusions  \nThis study highlights the critical role of GLO1 in the progression of cervical cancer, presenting it as a potential biomarker and therapeutic target. These findings contribute valuable insights towards personalized treatment approa","cbCaioZJCXI33Nao","https://ap.wps.com/l/cbCaioZJCXI33Nao","pdf",1730884,14,"English","# Abstract\n# Introduction\n# Methods\n# Results\n# Conclusions","[{\"question\":\"What is the main biological focus of the study?\",\"answer\":\"The study focuses on Glyoxalase-1 (GLO1) and its role in methylglyoxal detoxification in cervical cancer progression.\"},{\"question\":\"How was GLO1 expression assessed in patient samples?\",\"answer\":\"GLO1 expression was assessed in cervical cancer patient samples using immunohistochemistry.\"},{\"question\":\"What effects did GLO1 inhibition have in vitro?\",\"answer\":\"GLO1 inhibition decreased cell viability and migration in cervical cancer cell lines, including HeLa-based in vitro experiments.\"},{\"question\":\"What do the analyses suggest about GLO1 and cancer metabolism?\",\"answer\":\"Single-cell RNA sequencing and public gene expression datasets support GLO1 overexpression and its involvement in cancer metabolism, particularly glycolysis, with a progressive increase across disease stages.\"}]","Glyoxalase 1 - Emerging biomarker and therapeutic target in cervical cancer progression | PDF",1789997032,35]