[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332983-105":59,"doc-detail-332983-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","glycomic-profiling-of-parathyroid-neoplasms-via-lectin-microarray-analysis","Glycomic profiling of parathyroid neoplasms via lectin microarray analysis","","Parathyroid carcinoma (PC) is a rare malignancy with poor prognosis, and reliable diagnostic markers for distinguishing PC from benign parathyroid adenoma (PA) remain limited. This study compares overall lectin-specific glycosylation patterns between PC and PA tissues using a 70-lectin microarray, then validates lectins showing significant differential response with lectin histochemistry. Most PCs show higher lectin signal intensities than PAs, with amaranthus caudatus (ACL) displaying the strongest difference.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/glycomic-profiling-of-parathyroid-neoplasms-via-lectin-microarray-analysis/332983/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/glycomic-profiling-of-parathyroid-neoplasms-via-lectin-microarray-analysis/332983.png","ImageObject",300,407,{"name":92,"@type":93},"Valentina","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main purpose of the study?","Question",{"text":112,"@type":113},"To identify glycomic differences between parathyroid carcinoma (PC) and parathyroid adenoma (PA) and to find efficient diagnostic markers for differential diagnosis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were glycosylation patterns assessed?",{"text":117,"@type":113},"The study used a lectin microarray containing 70 lectins to compare lectin-specific glycosylation patterns between PC (n=8) and PA (n=6) tissues.",{"name":119,"@type":110,"acceptedAnswer":120},"Which lectin showed the most significant difference between PC and PA?",{"text":121,"@type":113},"Amaranthus caudatus (ACL) showed the most strongly differential response, and lectin histochemistry further confirmed higher ACL intensity in PCs than in PAs.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332983,1790790369,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},13056703020460,"https://ap-avatar.wpscdn.com/avatar/be000253dac470eee5d?_k=1778207105932848923","Endocrine (2025) 87:1224–1234  \n[https://doi.org/10.1007/s12020-024-04107-5](https://doi.org/10.1007/s12020-024-04107-5)  \nGlycomic profiling of parathyroid neoplasms via lectin microarray analysis  \nQingyuan Zheng1 ● Ming Cui1 ● Jinheng Xiao1 ● Sen Yang1 ● Tianqi Chen2 ● Yanan Shi2 ● Ya Hu1 ● Quan Liao1  \nReceived: 18 September 2024 / Accepted: 7 November 2024 / Published online: 20 November 2024 © The Author(s) 2024  \nAbstract  \nPurpose Parathyroid carcinoma (PC) is a rare malignancy with a poor prognosis. Diagnosis of PC is often difficult in clinical practice and efficient diagnostic markers are still needed for differential diagnosis. Aberrant glycosylations of glycoproteins were identified with lectin microarray in various cancers, while relevant information is lacking in PC.  \nMethods In this study, 8 PC and 6 parathyroid adenoma (PA) tissues were assessed using a microarray consisting of 70 lectins. Overall lectin-specific glycosylation patterns were compared between PA and PC tissues. Lectins with significant differential response between PC and PA were further validated by lectin histochemistry.  \nResults The difference in signal intensities was found in 71.4%(50/70) of the lectins between the two groups (P \u003C 0.05) . The vast majority of PCs had higher intensity signals than PAs (PCs vs. PAs, ratio >1) and amaranthus caudatus (ACL) showed the most significantly different response between them (ratio = 2.45) . Lectin histochemistry further confirmed higher ACL intensity in PCs than in PAs. The differentially expressed glycans in PC tissues were primarily glucose, mannose, and galactose-based.  \nConclusion PC presented unique glycomic features and ACL may serve as a candidate diagnostic marker for PC. Keywords Parathyroid carcinoma ● Parathyroid tumor ● Glycosylation ● Lectin microarray ● Biomarker  \nIntroduction  \nParathyroid carcinoma (PC) is a relatively rare endocrine neoplasm that exhibits clinical presentations and imaging characteristics sometimes closely resembling those of parathyroid adenoma (PA) . Benign and malignant parathyroid tumors exhibit many similarities in their pathological  \nThese authors contributed equally: Qingyuan Zheng, Ming Cui  \n* Ya Hu [huyafrank@sohu.com](huyafrank@sohu.com)  \n* Quan Liao[lqpumc@126.com](lqpumc@126.com)  \n1 Department of General Surgery, Peking Union Medical College Hospital, State Key Laboratory of Complex Severe and Rare Disease, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China  \n2 Biomedical Engineering Facility of National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China  \nmorphology under a light microscope, which presents a diagnostic challenge [1, 2] . The parafibromin encoded by Cell Division Cycle 73 (CDC73) is an important differential marker of parathyroid tumors. However, CDC73 mutations may also be found in some PAs [3–5] . Therefore, it is particularly important to explore simple and efficient diagnostic markers for parathyroid tumors.  \nGlycosylation is a crucial posttranslational modification that plays a pivotal role in cell recognition, immune response, and signaling [6–9] . In recent years, there has been growing recognition of the association of aberrant glycosylations with tumor development. Structural changes in glycans induced by glycosylation actively promote the proliferation and migration of tumor cells [10, 11] . For instance, the ST6GALNAC4 may induce abnormal glycosylation of transforming growth factor beta receptor 2 to promote hepatocellular carcinogenesis [12] . However, direct detection of glycobiomarkers is not only low throughput but also time-consuming. With the advances in technology, high-throughput screening of tumor-specificglycosylations has become possible [13] .  \nLectins are a class of naturally occurring proteins that are widely used in studies of glycan mod","cbCaie2gMs0W7W6Z","https://ap.wps.com/l/cbCaie2gMs0W7W6Z","pdf",2462101,11,"English","# Abstract\n## Purpose\n## Methods\n## Results\n## Conclusion\n# Introduction\n## Clinical challenge in differential diagnosis\n## Role of glycosylation\n## Rationale for lectin microarrays","[{\"question\":\"What is the main purpose of the study?\",\"answer\":\"To identify glycomic differences between parathyroid carcinoma (PC) and parathyroid adenoma (PA) and to find efficient diagnostic markers for differential diagnosis.\"},{\"question\":\"How were glycosylation patterns assessed?\",\"answer\":\"The study used a lectin microarray containing 70 lectins to compare lectin-specific glycosylation patterns between PC (n=8) and PA (n=6) tissues.\"},{\"question\":\"Which lectin showed the most significant difference between PC and PA?\",\"answer\":\"Amaranthus caudatus (ACL) showed the most strongly differential response, and lectin histochemistry further confirmed higher ACL intensity in PCs than in PAs.\"}]","Glycomic profiling of parathyroid neoplasms via lectin microarray analysis | PDF",1790000282,28]