[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-349869-105":3,"detail-sidebar-cat-0-en-105":80,"doc-detail-349869-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":73,"head_meta":75,"extra_data":77,"updated_unix":79},105,"en","glycolysis-enzymes-and-cellular-lactylation-in-tumour","Glycolysis enzymes and cellular lactylation in tumour","","Cellular lactylation, a recently identified post-translational modification, is described as a crucial regulator of diverse biological processes, with strong emphasis on cancer. The review frames lactylation as a new lens for interpreting the functional meaning of the Warburg effect in tumour cells. It explains how glycolytic pathway enzymes modulate lactylation, thereby shaping tumour genesis and progression. 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The review emphasizes its crucial regulatory roles across biological processes, particularly in tumour development and progression.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"How do glycolysis enzymes influence lactylation in tumour cells?",{"text":67,"@type":63},"The review states that glycolytic enzymes such as hexokinase, phosphofructokinase-1, and lactate dehydrogenase drive lactate production and regulate lactylation patterns. This connects metabolic reprogramming to protein modification and tumour behaviors.",{"name":69,"@type":60,"acceptedAnswer":70},"What therapeutic potential does targeting lactylation offer?",{"text":71,"@type":63},"The review concludes that lactylation may serve as a biomarker for cancer prognosis and a target for therapeutic intervention. It summarizes the potential of targeting lactylation as a cancer therapy strategy.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},349869,1790193655,{"code":4,"msg":81,"data":82},"success",[83,87,91,95,100,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":84,"show_sort_weight":85,"slug":86},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":88,"show_sort_weight":89,"slug":90},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":92,"show_sort_weight":93,"slug":94},"Exam",70,"exam",{"id":96,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},5,"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":96,"slug":129},19,"General","general",{"code":4,"msg":81,"data":131},{"doc_id":78,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":22,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":98},7971461740886,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","DOI: 10.1002/ctm2.70549  \nREVIEW  \nGlycolysis enzymes and cellular lactylation in tumour  \nChenyuan Dai  Lihua Wang   \nDepartment of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China  \nCorrespondence  \nLihua Wang, Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.  \n[Email:](Email: wlihua@fudan.edu.cn)[ wlihua@fudan.edu.cn](Email: wlihua@fudan.edu.cn)  \nGraphical Abstract  \nGraphical Headlights  \n• Glycolytic enzymes regulate lactylation in cancer cells.  \n• Lactylation drives tumour growth, metastasis, immune evasion and contributes to microenvironment remodelling.  \n• Targeting lactylation holds promise for cancer therapy.  \nClin. Transl. Med. 2026;16:e70549 .  \n[https://doi.org/10.1002/ctm2.70549](https://doi.org/10.1002/ctm2.70549)  \n[wileyonlinelibrary.com/journal/ctm2](wileyonlinelibrary.com/journal/ctm2)  \nDOI: 10.1002/ctm2.70549  \nREVIEW  \nGlycolysis enzymes and cellular lactylation in tumour  \nChenyuan Dai  Lihua Wang   \nDepartment of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China  \nCorrespondence  \nLihua Wang, Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China. [Email:](Email: wlihua@fudan.edu.cn)[ wlihua@fudan.edu.cn](Email: wlihua@fudan.edu.cn)  \nFunding information  \nFudan University, Grant/Award Number: JIF101242Y  \nAbstract  \nCellular lactylation, a recently identified post-translational modification, has emerged as a crucial regulator in various biological processes, particularly in cancer. The discovery of lactylation provides a new perspective for understanding the functional significance of the Warburg effect in tumour cells. Enzymes involved in the glycolytic pathway modulate lactylation, influencing tumour genesis and progression. This review explores the intricate relationship between glycolysis, lactylation and tumour biology, with a focus on how enzymes participating in glycolysis impact lactylation in cancer cells. We discuss how glycolytic enzymes regulate lactylation and highlight their broader implications in tumour biology. The role oflactylation in shaping the tumour microenvironment underscores its increasing significance as a biomarker for cancer prognosis and a target for therapeutic intervention. Therefore, we also summarised the potential of targeting lactylation as a cancer therapy strategy.  \nKEYWORDS  \nglycolysis enzymes, lactylation, protein post-translational modification, tumour genesis and progression  \nKey points  \n∙ Glycolytic enzymes regulate lactylation in cancer cells.  \n∙ Lactylation drives tumour growth, metastasis, immune evasion and contributes to microenvironment remodelling  \n∙ Targeting lactylation holds promise for cancer therapy.  \n1  INTRODUCTION  \nCellular metabolism is fundamental for maintaining organismal homeostasis, supporting essential functions such as energy production, biosynthesis and signal transduction.1,2 Proper regulation of these metabolic pathways is crucial for sustaining metabolic balance and  \nensuring normal physiological processes.3–5 Dysregulation of cellular metabolism is a hallmark of many diseases, especially cancer where metabolic reprogramming is commonly observed. Among these reprogramming events, the reliance of tumour cells on aerobic glycolysis—also known as the Warburg effect—represents a central metabolic adaptation.6 This metabolic shift favours glycolytic flux  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2025 The Author(s) . Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.  \nDAI and WANG  \neven in the presence of oxygen, resulting in excessive lactate production,","cbCaipVX9ZZ32AVP","https://ap.wps.com/l/cbCaipVX9ZZ32AVP","pdf",2625939,24,"English","# Graphical Abstract\n# Abstract\n# Key points\n# Introduction","[{\"question\":\"What is cellular lactylation and why is it important in cancer?\",\"answer\":\"Cellular lactylation is a post-translational modification driven by lactyl groups. The review emphasizes its crucial regulatory roles across biological processes, particularly in tumour development and progression.\"},{\"question\":\"How do glycolysis enzymes influence lactylation in tumour cells?\",\"answer\":\"The review states that glycolytic enzymes such as hexokinase, phosphofructokinase-1, and lactate dehydrogenase drive lactate production and regulate lactylation patterns. This connects metabolic reprogramming to protein modification and tumour behaviors.\"},{\"question\":\"What therapeutic potential does targeting lactylation offer?\",\"answer\":\"The review concludes that lactylation may serve as a biomarker for cancer prognosis and a target for therapeutic intervention. It summarizes the potential of targeting lactylation as a cancer therapy strategy.\"}]","Glycolysis enzymes and cellular lactylation in tumour | PDF",1790086034]