[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331856-105":59,"doc-detail-331856-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","glycerol-kinase-enzyme-is-a-prognostic-predictor-in-esophageal-carcinoma-associated-with-immune-cell-infiltration","Glycerol kinase enzyme is a prognostic predictor in esophageal carcinoma - associated with immune cell infiltration","","Lipid metabolism is closely linked to tumorigenesis, yet the function of glycerol kinase (GK) in esophageal carcinoma (ESCA) has remained unclear. Using database analyses, immunohistochemistry on clinical ESCA tumor and normal samples, and Kaplan–Meier survival evaluation of TCGA data, elevated GK expression is shown to be associated with worse patient outcomes. Multivariable regression identifies high GK as an independent prognostic risk factor. Furthermore, GK expression correlates with immune cell infiltration, particularly involving T and B lymphocytes, suggesting a potential prognostic biomarker and therapeutic target.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/glycerol-kinase-enzyme-is-a-prognostic-predictor-in-esophageal-carcinoma-associated-with-immune-cell-infiltration/331856/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/glycerol-kinase-enzyme-is-a-prognostic-predictor-in-esophageal-carcinoma-associated-with-immune-cell-infiltration/331856.png","ImageObject",300,407,{"name":92,"@type":93},"Himbo","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What does increased glycerol kinase (GK) expression indicate for ESCA patients?","Question",{"text":112,"@type":113},"Higher GK expression correlates with poorer ESCA outcomes, including overall survival and disease-specific survival. Statistical analyses also support high GK as an independent prognostic risk factor.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was GK expression evaluated in the study?",{"text":117,"@type":113},"GK expression was assessed using database information and validated with immunohistochemistry on clinical ESCA tumor samples and normal specimens. TCGA survival analyses with Kaplan–Meier plots were used to relate expression to prognosis.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the relationship between GK expression and the immune microenvironment?",{"text":121,"@type":113},"GK expression shows a significant correlation with immune infiltration, particularly involving certain T and B lymphocytes. This supports GK’s role as a biomarker linked to immune involvement.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331856,1790698498,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},687197100911,"https://ap-avatar.wpscdn.com/avatar/a000239b6f1da00475?x-image-process=image/resize,m_fixed,w_180,h_180&k=1785132997149421697","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nGlycerol kinase enzyme is a prognostic predictor in esophageal carcinoma  \nand is associated with immune cell infiltration  \nFei Ying, Xuyong Chen & Lihong Lv *  \nThe influence of lipid metabolism on tumorigenesis and progression has garnered significant attention. However, the role of Glycerol Kinase (GK), a key enzyme in glycerol metabolism, in Esophageal Carcinoma (ESCA) remains unclear. To further elucidate the relationship between GK and ESCA, we investigated GK expression levels using database information. Controlled studies employing immunohistochemistry were conducted on clinical ESCA tumor samples and normal specimens, confirming GK’s elevated expression in ESCA. Analysis of The Cancer Genome Atlas (TCGA) data via Kaplan–Meier (KM) survival plots revealed that increased GK expression correlates with poorer ESCA patient outcomes, particularly in overall survival (OS) and disease-specific survival (DSS) . Multiple regression analysis indicated that elevated GK expression is an independent risk factor affecting ESCA prognosis. Statistical analysis of prognostic data from clinical samples further corroborated this finding. Moreover, there appears to be a significant correlation between GK expression and immune infiltration, specifically involving certain T and B lymphocytes. In conclusion, elevated GK expression in ESCA is strongly linked to poor prognosis and increased immune cell infiltration, highlighting its potential as an independent prognostic biomarker and a viable therapeutic target.  \nKeywords GK, Esophageal carcinoma, Prognosis, Immune infiltration  \nEsophageal Carcinoma (ESCA),according to 2020 data ranks as one of the most prevalent malignancies worldwide, occupying the seventh position in incidence (604,000 new cases annually), and the sixth in mortality (544,000 deaths per year)1. Notably, the highest regional incidence rates are observed in East Asia, particularly among the Chinese population1. Unlike Europe and the United States, where esophageal adenocarcinoma (EA) is the predominant pathological type, esophageal squamous cell carcinoma (ESCC) is more prevalent in China1,2. There has been a significant improvement in patient outcomes due to the multidisciplinary and comprehensive treatment models in recent years. The five-year survival rate for patients treated in early stages can exceed 90%, in stark contrast to less than 30% for those with advanced-stage disease3. This disparity underscores the importance of early diagnosis and treatment in improving patient prognosis. However, the identification of reliable tumor markers for diagnosis and prognosis in ESCA remains limited.  \nGlycerol kinase (GK), a protein-coding gene, is expressed in various organs, including the esophagus and liver, with its highest expression in the kidney. The protein encoded by the GK gene plays a crucial role in glycerol uptake and metabolism, catalyzing the phosphorylation of glycerol using adenosine triphosphate (ATP) to produce adenosine diphosphate (ADP) and glycerol-3-phosphate (G3P). This process is essential for the synthesis of glycerolipids, proteins, and glucose. Mutations in this gene are associated with Glycerol Kinase Deficiency (GKD), a condition characterized primarily by hypertriglyceridemia and hypoglycemia4,5. Additionally, patients with complex GKD exhibit a wide range of symptoms, including congenital adrenal dysplasia, hyperglyceridemia, and progressive pseudohypertrophic myotonic dystrophy, which can be controlled by glucocorticoid supplementation4,5.  \nDepartment of Gastroenterology, Xianju People’s Hospital, NO.53 North East Road, Xianju County, Taizhou, Zhejiang  \nProvince, China.* email: [756073810@qq.com](756073810@qq.com)  \n[www. nature.com/scientificreports/](www. nature.com/scientificreports/)  \nExtensive research has established GK’s importance in maintaining normal physiological processes. Rahibet al.’s analysis confir","cbCaiqo1uTPtKU4j","https://ap.wps.com/l/cbCaiqo1uTPtKU4j","pdf",7520179,15,"English","# Glycerol kinase (GK) and ESCA\n## GK expression patterns in ESCA\n## Prognostic value of GK\n## Association with immune cell infiltration\n## Study aim and methods\n## Background: ESCA burden and lipid metabolism","[{\"question\":\"What does increased glycerol kinase (GK) expression indicate for ESCA patients?\",\"answer\":\"Higher GK expression correlates with poorer ESCA outcomes, including overall survival and disease-specific survival. Statistical analyses also support high GK as an independent prognostic risk factor.\"},{\"question\":\"How was GK expression evaluated in the study?\",\"answer\":\"GK expression was assessed using database information and validated with immunohistochemistry on clinical ESCA tumor samples and normal specimens. TCGA survival analyses with Kaplan–Meier plots were used to relate expression to prognosis.\"},{\"question\":\"What is the relationship between GK expression and the immune microenvironment?\",\"answer\":\"GK expression shows a significant correlation with immune infiltration, particularly involving certain T and B lymphocytes. This supports GK’s role as a biomarker linked to immune involvement.\"}]","Glycerol kinase enzyme is a prognostic predictor in esophageal carcinoma - associated with immune cell infiltration | PDF",1789995518,38]