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The study integrates multicohort transcriptomic and clinical data, along with digital pathology, live-cell imaging, and in vitro/in vivo modeling, to show that glutathione (GSH) pathway dysregulation underpins NAC resistance.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/glutathione-dynamics-is-a-potential-predictive-and-therapeutic-trait-for-neoadjuvant-chemotherapy-response-in-bladder-cancer/382974/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/glutathione-dynamics-is-a-potential-predictive-and-therapeutic-trait-for-neoadjuvant-chemotherapy-response-in-bladder-cancer/382974.png","ImageObject",300,407,{"name":92,"@type":93},"Mimi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is predicting response to preoperative cisplatin-based NAC in muscle-invasive bladder cancer still challenging?","Question",{"text":112,"@type":113},"Complete response rates are relatively low, and current clinicopathologic and molecular classifications are inadequate to reliably predict NAC response.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What does the study identify as fundamental to NAC resistance?",{"text":117,"@type":113},"Dysregulation of the glutathione (GSH) pathway is shown to be fundamental for NAC resistance in muscle-invasive bladder cancer.",{"name":119,"@type":110,"acceptedAnswer":120},"How do the findings suggest a therapeutic strategy beyond prediction?",{"text":121,"@type":113},"GSH dynamics is linked to cisplatin resistance, and combination treatment using a GSH dynamics modulator with cisplatin significantly suppresses tumor growth in an orthotopic xenograft model.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},382974,1790293745,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},2336477974920,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Article  \nGlutathione dynamics is a potential predictive and therapeutic trait for neoadjuvant chemotherapy response in bladder cancer  \nAuthors  \nYongHwan Kim, Hyein Ju, Seung-Yeon Yoo, ..., Jae Lyun Lee, Yong Mee Cho, Dong-Myung Shin  \nCorrespondence  \n[jaelyun@amc.seoul.kr](jaelyun@amc.seoul.kr) (J.L.L.),  \n[yongcho@amc.seoul.kr](yongcho@amc.seoul.kr) (Y.M.C.), [d0shin03@amc.seoul.kr](d0shin03@amc.seoul.kr) (D.-M.S.)  \nIn brief  \nKim et al. integrate multicohort transcriptomic and clinical data analysis of MIBC patients, digital pathology, livecell imaging, and in vitro and in vivo modeling. They highlight the importance of glutathione dynamics as a predictive biomarker for MIBC’s response topreoperative cisplatin-based neoadjuvant chemotherapy and a potential therapeutic target for chemoresistant MIBCs.  \nd MIBC multicohort analysis of molecular and clinical data for NAC responsiveness  \nd Discovery and validation of GSH dynamic features for predicting responses to NAC  \nd Glutaminase-1 is a key factor regulating GSH dynamics inhuman MIBC cells  \nd Modulation of GSH dynamics resensitizes chemoresistant MIBCs  \nKim et al., 2023, Cell Reports Medicine 4, 101224 October 17, 2023 ª 2023 The Author(s) .  \n[https://doi.org/10.1016/j.xcrm.2023.101224](https://doi.org/10.1016/j.xcrm.2023.101224)  \nll  \nll  \nOPEN ACCESS  \nArticle  \nGlutathione dynamics is a potential predictive and therapeutic trait for neoadjuvant chemotherapy response in bladder cancer  \nYongHwan Kim,1,13 Hyein Ju,1,13 Seung-Yeon Yoo,2,13 Jinahn Jeong,3 Jinbeom Heo,1 Seungun Lee,1 Ja-Min Park,3 Sun Young Yoon,3 Se Un Jeong,4 Jinyoung Lee,5 HongDuck Yun,1 Chae-Min Ryu,6 Jinah Lee,1 Yun Ji Nam,1 Hyungu Kwon,1 Jaekyoung Son,5 Gowun Jeong,7 Ji-Hye Oh,3 Chang Ohk Sung,3 Eui Man Jeong,8 Jaehoon An,9,10 Sungho Won,9,10 Bumsik Hong,11 Jae Lyun Lee,12,* Yong Mee Cho,3,* and Dong-Myung Shin1,14,*  \n1Department of Cell and Genetic Engineering, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea  \n2Pathology Center, Seegene Medical Foundation, Seoul 04805, Korea  \n3Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea  \n4Department of Pathology, Ewha Womans University College of Medicine, Ewha Womans University Mokdong Hospital, Seoul 07985, Korea  \n5Department of Biochemistry and Molecular Biology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea  \n6Center for Cell Therapy, Asan Medical Center, Seoul 05505, Korea  \n7AI Recommendation, T3K, SK Telecom, Seoul 04539, Korea  \n8College of Pharmacy, Jeju National University, Jeju 63243, Korea  \n9Department of Public Health Sciences, Seoul National University, Seoul 08826, Korea  \n10RexSoft, Inc. , Seoul 08826, Korea  \n11Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea  \n12Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea  \n13These authors contributed equally  \n14Lead contact  \n*Correspondence: [jaelyun@amc.seoul.kr](jaelyun@amc.seoul.kr) (J.L.L.), [yongcho@amc.seoul.kr](yongcho@amc.seoul.kr) (Y.M.C.), [d0shin03@amc.seoul.kr](d0shin03@amc.seoul.kr) (D.-M.S.) [https://doi.org/10.1016/j.xcrm.2023.101224](https://doi.org/10.1016/j.xcrm.2023.101224)  \nSUMMARY  \nRadical cystectomy with preoperative cisplatin-based neoadjuvant chemotherapy (NAC) is the standard care for muscle-invasive bladder cancers (MIBCs) . However, the complete response rate to this modality remains relatively low, and current clinicopathologic and molecular classifications are inadequate to predict NAC response in patients with MIBC. Here, we demonstrate that dysregulation of the glutathione (GSH) pathway is fundamental for MIBC NAC resistance. Comprehensive analysis of the multicohort transcriptomes reveals that GSH metabolism and immune-response genes are enriched in NAC-resistant and NAC-sensitive MIBCs, respectively. A machine-learning-based ","cbCaiicpMNCwVHgm","https://ap.wps.com/l/cbCaiicpMNCwVHgm","pdf",9889951,26,"English","# Summary\n# Introduction\n# Results (implied by study aims)\n## Multicohort transcriptomic and clinical analysis\n## Discovery and validation of GSH dynamic features\n## Role of glutaminase-1 in regulating GSH dynamics\n## Therapeutic targeting to resensitize chemoresistant tumors","[{\"question\":\"Why is predicting response to preoperative cisplatin-based NAC in muscle-invasive bladder cancer still challenging?\",\"answer\":\"Complete response rates are relatively low, and current clinicopathologic and molecular classifications are inadequate to reliably predict NAC response.\"},{\"question\":\"What does the study identify as fundamental to NAC resistance?\",\"answer\":\"Dysregulation of the glutathione (GSH) pathway is shown to be fundamental for NAC resistance in muscle-invasive bladder cancer.\"},{\"question\":\"How do the findings suggest a therapeutic strategy beyond prediction?\",\"answer\":\"GSH dynamics is linked to cisplatin resistance, and combination treatment using a GSH dynamics modulator with cisplatin significantly suppresses tumor growth in an orthotopic xenograft model.\"}]","Glutathione dynamics is a potential predictive and therapeutic trait for neoadjuvant chemotherapy response in bladder cancer | PDF",1790253325,66]