[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-328492-105":59,"doc-detail-328492-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","glut5-overexpression-related-tumorigenic-implications","GLUT5-overexpression-related tumorigenic implications","","Glucose transporter 5 (GLUT5) overexpression has gained increasing attention for its role in tumorigenesis. The review consolidates evidence that GLUT5 is upregulated across multiple cancer types, reshaping fructose metabolism and promoting oxygen-independent glycolysis-like adaptations. These metabolic changes provide tumors with alternative energy and support uncontrolled growth and survival. GLUT5 overexpression also links to immune evasion mechanisms, worsening progression and complicating treatment. The review positions GLUT5 as a diagnostic and therapeutic target and emphasizes the need for mechanistic research to exploit vulnerabilities in GLUT5-overexpressing cancers.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/glut5-overexpression-related-tumorigenic-implications/328492/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/glut5-overexpression-related-tumorigenic-implications/328492.png","ImageObject",300,407,{"name":92,"@type":93},"Oliver","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What biological role does GLUT5 play in cancer when overexpressed?","Question",{"text":112,"@type":113},"GLUT5 overexpression is associated with altered fructose metabolism and enhanced glycolysis-like behavior, helping cancer cells access energy for growth and survival.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does GLUT5 overexpression contribute to tumor progression beyond metabolism?",{"text":117,"@type":113},"Recent findings indicate GLUT5 can support immune evasion, which further accelerates tumor progression and makes therapy more difficult.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is GLUT5 considered a potential diagnostic marker and therapeutic target?",{"text":121,"@type":113},"Because GLUT5 overexpression connects to metabolic reprogramming and immune modulation, understanding its molecular drivers could enable targeted strategies that disrupt GLUT5-dependent vulnerabilities.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},328492,1790145486,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},8796095461610,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Hadzi-Petrushev etal. Molecular Medicine (2024) 30:114 Molecular Medicine  \n[https://doi.org/10.1186/s10020-024-00879-8](https://doi.org/10.1186/s10020-024-00879-8)  \nREVIEW Open Access  \nGLUT5-overexpression-related tumorigenic implications  \nNikola Hadzi-Petrushev 1†, Radoslav Stojchevski2,3,4†, Anastasija Jakimovska 1, Mimoza Stamenkovska 1, Slavica Josifovska 1, Aleksandar Stamatoski5, Iliyana Sazdova6, Ramadan Sopi7, Andre Kamkin8, Hristo Gagov6, Mitko Mladenov 1,8† and Dimiter Avtanski2,3,4*†  \nAbstract  \nGlucose transporter 5 (GLUT5) overexpression has gained increasing attention due to its profound implications for tumorigenesis. This manuscript provides a comprehensive overview of the key findings and implications associated with GLUT5 overexpression in cancer. GLUT5 has been found to be upregulated in various cancer types, leading to alterations in fructose metabolism and enhanced glycolysis, even in the presence of oxygen, a hallmark of cancer cells. This metabolic shift provides cancer cells with an alternative energy source and contributes to their uncontrolled growth and survival. Beyond its metabolic roles, recent research has unveiled additional aspects of GLUT5 in cancer biology. GLUT5 overexpression appears to play a critical role in immune evasion mechanisms, which further worsens tumor progression and complicates therapeutic interventions. This dual role of GLUT5 in both metabolic reprogramming and immune modulation highlights its significance as a potential diagnostic marker and therapeutic target. Understanding the molecular mechanisms driving GLUT5 overexpression is crucial for developing targeted therapeutic strategies that can disrupt the unique vulnerabilities of GLUT5-overexpressing cancer cells. This review emphasizes the complexities surrounding GLUT5’s involvement in cancer and underscores the pressing need for continued research to unlock its potential as a diagnostic biomarker and therapeutic target, ultimately improving cancer management and patient outcomes.  \nKeywords GLUT5, Fructose, Tumorigenesis, Pharmacokinetics, Nano-formulation  \n\n| †Nikola Hadzi-Petrushev and Radoslav Stojchevski contributed equally to this work and are recognized as co-first authors. |\n| --- |\n| †Dimiter Avtanski and Mitko Mladenov participated equally as senior authors. |\n\n*Correspondence: Dimiter Avtanski [davtanski@northwell.edu](davtanski@northwell.edu)  \n1Institute of Biology, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University, Skopje 1000, North Macedonia  \n2Friedman Diabetes Institute, Lenox Hill Hospital, Northwell Health, 110 E 59th Street, New York, NY 10022, USA  \n3Feinstein Institutes for Medical Research, Manhasset, NY 11030, USA 4Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549, USA  \n5Faculty of Dental Medicine, University Clinic for Maxillofacial Surgery in Skopje, Ss. Cyril and Methodius University, Skopje 1000, North Macedonia 6Department of Animal and Human Physiology, Faculty of Biology, Sofia University ‘St. Kliment Ohridski’, Sofia 1504, Bulgaria  \n7Faculty of Medicine, University of Prishtina, Prishtina 10 000, Kosovo 8Institute of Physiology of the Federal State Autonomous Educational Institution of Higher Education“N. I. Pirogov Russian National Research Medical University” Ministry of Health, Moscow, Russian Federation  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons","cbCaisecvdk4m4RT","https://ap.wps.com/l/cbCaisecvdk4m4RT","pdf",3974895,"English","# Abstract\n# Introduction\n## Structure, function, and regulation of GLUT5","[{\"question\":\"What biological role does GLUT5 play in cancer when overexpressed?\",\"answer\":\"GLUT5 overexpression is associated with altered fructose metabolism and enhanced glycolysis-like behavior, helping cancer cells access energy for growth and survival.\"},{\"question\":\"How does GLUT5 overexpression contribute to tumor progression beyond metabolism?\",\"answer\":\"Recent findings indicate GLUT5 can support immune evasion, which further accelerates tumor progression and makes therapy more difficult.\"},{\"question\":\"Why is GLUT5 considered a potential diagnostic marker and therapeutic target?\",\"answer\":\"Because GLUT5 overexpression connects to metabolic reprogramming and immune modulation, understanding its molecular drivers could enable targeted strategies that disrupt GLUT5-dependent vulnerabilities.\"}]","GLUT5-overexpression-related tumorigenic implications | PDF",1789979980,48]