[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-331802-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-331802-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","glucose-regulated-protein-78-targeting-icg-and-dox-loaded-hollow-fe3o4-nanoparticles-for-hepatocellular-carcinoma-diagnosis-and-therapy","Glucose-Regulated Protein 78 Targeting ICG and DOX Loaded Hollow Fe3O4 Nanoparticles for Hepatocellular Carcinoma Diagnosis and Therapy","","Hepatocellular carcinoma accounts for about 90% of liver cancers and remains a major cause of cancer-related death, often diagnosed at advanced stages due to insufficient screening. Local recurrence after resection and limited penetration and accuracy of light-based phototherapies hinder outcomes. This study constructs SP94-Fe3O4@ICG&DOX nanoparticles and evaluates their ability to support in vitro release, photothermal/photodynamic performance, in vivo imaging, and combined photochemotherapy inhibition in Hepa1-6, with attention to biosafety.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/glucose-regulated-protein-78-targeting-icg-and-dox-loaded-hollow-fe3o4-nanoparticles-for-hepatocellular-carcinoma-diagnosis-and-therapy/331802/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/glucose-regulated-protein-78-targeting-icg-and-dox-loaded-hollow-fe3o4-nanoparticles-for-hepatocellular-carcinoma-diagnosis-and-therapy/331802.png","ImageObject",300,407,{"name":42,"@type":43},"Jiven","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main objective of this study on HCC?","Question",{"text":63,"@type":64},"To construct SP94-Fe3O4@ICG&DOX nanoparticles and evaluate their potential for both diagnosis and treatment benefits in hepatocellular carcinoma.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What key properties and performance are tested for the nanoparticles?",{"text":68,"@type":64},"The study synthesizes and characterizes SP94-Fe3O4@ICG&DOX nanoparticles, confirms in vitro release behavior, and evaluates photothermal and photodynamic performance, including in vivo imaging capability.",{"name":70,"@type":61,"acceptedAnswer":71},"How do the results support tumor diagnosis and therapy?",{"text":72,"@type":64},"The nanoparticles show strong MPI and fluorescence imaging for precise tumor localization and demonstrate synergistic photo-chemotherapy effects, with laser-triggered temperature rise and effective inhibition of tumor cell proliferation.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},331802,1790090448,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":112,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":113,"slug":114},8,30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":112,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":118,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":104,"preview_page_count":4},1099513958607,"https://ap-avatar.wpscdn.com/avatar/100002390cf8733938c?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778829742770036399","International Journal of Nanomedicine Dovepress  \nopen access to scientific and medical research  \n Open Access Full Text Article ORIGINAL RESEARCH  \nGlucose-Regulated Protein 78 Targeting ICG and DOX Loaded Hollow Fe 3 O4 Nanoparticles for Hepatocellular Carcinoma Diagnosis and Therapy  \nYushen Jin 1 , Zhongquan Cheng2 , Zhu Yuan 2 , Yang Du 3 , Jie Tian 3 , Bing Shao 1 ,4  \n1Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Centre for Disease Prevention and Control, Beijing, 100013, People’s Republic of China; 2Department of General Surgery, Capital Medical University, Beijing Friendship Hospital, Beijing, 100050, People’s Republic of China; 3CAS Key Laboratory of Molecular Imaging, Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, People’s Republic of China; 4College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People’s Republic of China  \nCorrespondence: Bing Shao; Jie Tian, Email [shaobingch@sina.com](shaobingch@sina.com); [jietian@ia.ac.cn](jietian@ia.ac.cn)  \n\n| Purpose: Liver cancer is considered as the third leading cause of cancer-related deaths, with hepatocellular carcinoma (HCC) accounting for approximately 90% of liver cancers. Improving the treatment of HCC is a serious challenge today. The primary objective of this study was to construct SP94-Fe3O4@ICG&DOX nanoparticles and investigate their potential diagnosis and treatment effect benefits on HCC.\u003Cbr>Methods: Firstly, we synthesized and characterized SP94-Fe3O4@ICG&DOX nanoparticles and confirmed their in vitro release behavior, photothermal and photodynamic performance. Moreover, the in vivo imaging capability was also observed. Finally, the inhibitory effects on Hepa1-6 in vitro and in vivo were observed as well as biosafety.\u003Cbr>Results: SP94-Fe3O4@ICG&DOX nanoparticles have a size of ~22.1 nm, with an encapsulation efficiency of 45.2% for ICG and 42.7% for DOX, showing excellent in vivo MPI and fluorescence imaging capabilities for precise tumor localization, and synergistic photo-chemotherapy (pH-and thermal-sensitive drug release) against tumors under irradiation. With the assistance of a fluorescence molecular imaging system or MPI scanner, the location and contours of the tumor were clearly visible. Under a constant laser irradiation (808 nm, 0.6 W/cm2) and a set concentration (50 µg/mL), the temperature of the solution could rapidly increase to ~45 °C, which could effectively kill the tumor cells. It could be effectively uptaken by HCC cells and significantly inhibit their proliferation under the laser irradiation (100% inhibition rate for HCC tumors) . And most importantly, our nanoparticles exhibited favorable biocompatibility with normal tissues and cells.\u003Cbr>Conclusion: This versatile agent can serve as an intelligent and promising nanoplatform that integrates multiple accurate diagnoses, precise positioning of cancer tissue, and effective coordination with synergistic tumor photodynamic therapy.\u003Cbr>Keywords: porous hollow structure, magnetic particle imaging, fluorescence imaging, synergistic treatment, theranostics |\n| --- |\n| Introduction\u003Cbr>Hepatocellular carcinoma (HCC), accounts for approximately 90% of liver cancers, is a primary malignancy tumor.1,2 Liver cancer is considered the third leading cause of cancer-related deaths3 with nearly 830, 000 deaths globally in 2020, of which 390,000 occurred in China.4 Due to insufficient screening, HCC is usually diagnosed at an advanced stage.5,6 Clinically, local recurrence of residual tiny tumors after radical resection is one of the main causes leading to treatment failure. Photothermal therapy (PTT) and photodynamic therapy (PDT) have been recognized as common phototherapy regimens for tumor treatment; however, their therapeutic outcomes have been limited owing to the limited penetration depth of light and low therapeutic accuracy.7–9 To further prolong the survival tim","cbCaikaBmCK7WVUs","https://ap.wps.com/l/cbCaikaBmCK7WVUs","pdf",17503850,"English","# Purpose\n# Methods\n# Results\n# Conclusion\n# Introduction","[{\"question\":\"What is the main objective of this study on HCC?\",\"answer\":\"To construct SP94-Fe3O4@ICG\\u0026DOX nanoparticles and evaluate their potential for both diagnosis and treatment benefits in hepatocellular carcinoma.\"},{\"question\":\"What key properties and performance are tested for the nanoparticles?\",\"answer\":\"The study synthesizes and characterizes SP94-Fe3O4@ICG\\u0026DOX nanoparticles, confirms in vitro release behavior, and evaluates photothermal and photodynamic performance, including in vivo imaging capability.\"},{\"question\":\"How do the results support tumor diagnosis and therapy?\",\"answer\":\"The nanoparticles show strong MPI and fluorescence imaging for precise tumor localization and demonstrate synergistic photo-chemotherapy effects, with laser-triggered temperature rise and effective inhibition of tumor cell proliferation.\"}]","Glucose-Regulated Protein 78 Targeting ICG and DOX Loaded Hollow Fe3O4 Nanoparticles for Hepatocellular Carcinoma Diagnosis and Therapy | PDF",1789995227]