[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-378622-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-378622-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","glucose-metabolic-reprogramming-and-its-therapeutic-potential-in-obesity-associated-endometrial-cancer","Glucose metabolic reprogramming and its therapeutic potential in obesity-associated endometrial cancer","","Endometrial cancer (EC) is a common gynecological malignancy whose incidence remains high despite advances in management. Obesity, prevalent worldwide, elevates EC risk but the mechanistic link is not fully resolved. EC displays emerging metabolic reprogramming features: obesity drives insulin resistance and hyperglycaemia, reshaping systemic metabolism and worsening prognosis. Glucose utilization in EC involves glycolysis and mitochondrial pathways, influencing initiation and progression. This review focuses on glucose metabolic regulation in both systemic and tumor-intrinsic metabolism, aiming to guide future therapeutic strategies.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/glucose-metabolic-reprogramming-and-its-therapeutic-potential-in-obesity-associated-endometrial-cancer/378622/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/glucose-metabolic-reprogramming-and-its-therapeutic-potential-in-obesity-associated-endometrial-cancer/378622.png","ImageObject",300,407,{"name":42,"@type":43},"anakgang17","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",12,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why does obesity increase the risk of endometrial cancer?","Question",{"text":63,"@type":64},"Obesity is associated with insulin resistance, hyperinsulinemia, and hyperglycaemia. This metabolic disruption remodels systemic status, thereby increasing EC risk and contributing to poor prognosis.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What does glucose metabolic reprogramming involve in endometrial cancer?",{"text":68,"@type":64},"Glucose metabolic reprogramming includes rewiring glucose handling to satisfy energy requirements. In EC cells, glucose metabolism is mediated by glycolysis and mitochondria, supporting malignant behaviors.",{"name":70,"@type":61,"acceptedAnswer":71},"How could understanding glucose metabolism help treatment?",{"text":72,"@type":64},"Clarifying metabolic profiles and the regulation mechanisms linking glucose metabolism to EC may provide novel perspectives for developing treatment strategies targeting these pathways.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},378622,1790484866,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":146},962090883568,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Huang et al. Journal of Translational Medicine (2023) 21:94  \n[https://doi.org/10.1186/s12967-022-03851-4](https://doi.org/10.1186/s12967-022-03851-4)  \nJournal of Translational Medicine  \n REVIEW Open Access  \nGlucose metabolic reprogramming and its   therapeutic potential in obesity-associated endometrial cancer  \nPengzhu Huang1,2, Xiangqin Fan1,2, Hongfei Yu1,2, Kaiwen Zhang1,2, Huanrong Li1,2, Yingmei Wang1,2* and Fengxia Xue1,2*  \nAbstract  \nEndometrial cancer (EC) is a common gynecological cancer that endangers women health. Although substantial progresses of EC management have been achieved in recent years, the incidence of EC still remains high. Obesity has been a common phenomenon worldwide that increases the risk of EC. However, the mechanism associating obesity and EC has not been fully understood. Metabolic reprogramming as a remarkable characteristic of EC is currently emerging. As the primary factor of metabolic syndrome, obesity promotes insulin resistance, hyperinsulinemia and hyperglycaemia. This metabolic disorder remodels systemic status, which increases EC risk and is related with poor prognosis. Glucose metabolism in EC cells is complex and mediated by glycolysis and mitochondria to ensure energy requirement. Factors that affect glucose metabolism may have an impact on EC initiation and progression. In this study, we review the glucose metabolic reprogramming of EC not only systemic metabolism but also inherent tumor cell metabolism. In particular, the role of glucose metabolic regulation in malignant properties of EC will be focused. Understanding of metabolic profile and glucose metabolism-associated regulation mechanism in EC may provide novel perspective for treatment.  \nKeywords Endometrial cancer, Metabolic syndrome, Glucose metabolic reprogramming, Glycolysis, Mitochondria  \nIntroduction  \nEndometrial cancer (EC) is one of the most common gynecologic malignancies worldwide. The incidence of EC is rising in recent years especially in young women, which deeply influences reproductive health and imposes heavy social burden. The American Cancer Society estimates that in 2022, there would be 65,950 new cases and  \n*Correspondence:  \nYingmei Wang [wangyingmei@tmu.edu.cn](wangyingmei@tmu.edu.cn)[ ](wangyingmei@tmu.edu.cn)Fengxia Xue [xuefengxia@tmu.edu.cn](xuefengxia@tmu.edu.cn)  \n1 Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin 300052, China  \n2 Tianjin Key Laboratory of Female Reproductive Health and Eugenics, Tianjin Medical University General Hospital, Tianjin, China  \n12,550 deaths with EC in the United States, making it the fourth most common cancer and the sixth most common causes of cancer death of women [1]. As the most common subtype of EC, endometrioid carcinoma (type I) is hormone-receptor-positive with less-aggressive characteristic and better prognosis compared with type II. Multiple factors contribute to the development of EC including obesity, metabolic dysregulation, excess estrogen and genetic predisposition [2]. Standard treatment for EC is primary hysterectomy and bilateral salpingooophorectomy, whereas lymph node dissection, adjuvantor targeted treatment is conducted according to the clinical pathological and molecular characteristic. Progestinbased conservative treatment of EC is viable for those women who wish to preserve fertility with well-differentiated, clinical stage 1 A, endometrioid EC [3]. Although  \n© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless ind","cbCaiu0heVP76KoH","https://ap.wps.com/l/cbCaiu0heVP76KoH","pdf",1006619,14,"English","# Abstract\n# Introduction\n# Glucose metabolism in endometrial cancer\n# Metabolic reprogramming and therapeutic implications","[{\"question\":\"Why does obesity increase the risk of endometrial cancer?\",\"answer\":\"Obesity is associated with insulin resistance, hyperinsulinemia, and hyperglycaemia. This metabolic disruption remodels systemic status, thereby increasing EC risk and contributing to poor prognosis.\"},{\"question\":\"What does glucose metabolic reprogramming involve in endometrial cancer?\",\"answer\":\"Glucose metabolic reprogramming includes rewiring glucose handling to satisfy energy requirements. In EC cells, glucose metabolism is mediated by glycolysis and mitochondria, supporting malignant behaviors.\"},{\"question\":\"How could understanding glucose metabolism help treatment?\",\"answer\":\"Clarifying metabolic profiles and the regulation mechanisms linking glucose metabolism to EC may provide novel perspectives for developing treatment strategies targeting these pathways.\"}]","Glucose metabolic reprogramming and its therapeutic potential in obesity-associated endometrial cancer | PDF",1790231544,35]