[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-26602-105":3,"detail-sidebar-cat-0-en-105":64,"doc-detail-26602-en":114},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":56,"head_meta":59,"extra_data":61,"updated_unix":63},105,"en","glomerular-diseases","Glomerular diseases","","Glomerular diseases constitute a significant portion of acute and chronic kidney disease, stemming from diverse causes including immunological injury, inherited disorders like Alport syndrome, metabolic conditions such as diabetes mellitus, and the deposition of abnormal proteins like amyloid within the glomeruli. The glomerulus, a crucial filtration unit in the kidney, can be targeted by injury at various cellular levels, including the endothelium which is indirectly affected, the glomerular basement membrane (GBM), the mesangium, and the podocytes. Specific conditions associated with damage to these components include small-vessel vasculitis and ANCA in serum affecting the endothelium; Goodpasture's disease and anti-GBM antibody associated with GBM damage; IgA nephropathy and serum IgA increase linked to mesangial injury; and membranous nephropathy with anti-phospholipase A2 receptor 1 antibodies affecting podocytes. Circulating immune complexes, such as cryoglobulins in serum, hypocomplementemic urticarial vasculitis syndrome, and endocarditis, also play a role in the pathogenesis of glomerular diseases. Furthermore, planted antigens can trigger conditions like systemic lupus erythematosus (SLE), characterized by ANA and anti-dsDNA antibodies in serum, and post-infectious glomerulonephritis. Glomerulonephritis, literally meaning inflammation of the glomeruli, is often used broadly to encompass all glomerular diseases, many of which are immunologically mediated and responsive to immunosuppressive drugs. Diagnosis aids include testing for circulating or glomerular deposition of antibodies. GN is categorized into primary diseases (e.g., membranous GN, IgA nephropathy) and secondary diseases due to systemic illness (e.g., post-infectious GN, diabetic nephropathy, lupus nephritis). Presentation-based classification includes rapidly progressive GN, marked by hematuria, nephritic features, sub-acute renal failure, and often crescents on biopsy.",{"@graph":14,"@context":55},[15,34],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/glomerular-diseases/26602/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/glomerular-diseases/26602.png","ImageObject",300,407,{"name":42,"@type":43},"Ezra","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-09-18","2026-05-08",true,{"@type":52,"interactionType":53,"userInteractionCount":26},"InteractionCounter",{"@type":54},"ViewAction","https://schema.org",{"og:url":57,"og:type":58,"og:title":10,"og:site_name":45,"og:description":12},"https://docshare.wps.com/document/glomerular-diseases/26602","article",{"robots":60,"canonical":57},"index,follow",{"doc_id":62,"site_id":7},26602,1778199090,{"code":4,"msg":65,"data":66},"success",[67,71,75,79,84,89,93,98,103,106,110],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":68,"show_sort_weight":69,"slug":70},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":72,"show_sort_weight":73,"slug":74},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":76,"show_sort_weight":77,"slug":78},"Exam",70,"exam",{"id":80,"doc_module":4,"doc_module_name":25,"category_name":81,"show_sort_weight":82,"slug":83},5,"Comic",60,"comic",{"id":85,"doc_module":4,"doc_module_name":25,"category_name":86,"show_sort_weight":87,"slug":88},6,"Technology",50,"technology",{"id":90,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":91,"slug":92},7,40,"healthcare",{"id":94,"doc_module":4,"doc_module_name":25,"category_name":95,"show_sort_weight":96,"slug":97},8,"Research & Report",30,"research-report",{"id":99,"doc_module":4,"doc_module_name":25,"category_name":100,"show_sort_weight":101,"slug":102},9,"Religion & Spirituality",20,"religion-spirituality",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":104,"show_sort_weight":101,"slug":105},"World Cup","world-cup",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":107,"slug":109},10,"Lifestyle","lifestyle",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":80,"slug":113},19,"General","general",{"code":4,"msg":65,"data":115},{"doc_id":62,"user_id":116,"nickname":42,"user_avatar":117,"doc_module":4,"category_id":90,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":11,"file_id":118,"file_url":119,"file_type":120,"file_size":121,"view_count":26,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":122,"language":123,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":11,"faqs":11,"seo_title":124,"seo_description":12,"update_tm":63,"read_time":125},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","cbCaidaa7AWXaRXA","https://ap.wps.com/l/cbCaidaa7AWXaRXA","pdf",11203037,51,"English","Glomerular diseases | PDF",129]