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It covers the epidemiology, noting its rarity and status as the most common hereditary nephritis. The etiology is attributed to mutations or deletions in the COL4A5 gene on the X chromosome, encoding type IV collagen, with X-linked inheritance being most common (80%), followed by autosomal recessive (15%) and autosomal dominant (5%) forms. The disease is typically more severe in males. The pathophysiology involves a genetic defect in type IV collagen chains, a component of the basement membrane in the kidneys, eyes, and cochlea, leading to kidney damage (glomerulonephritis), sensorineural hearing loss, and ocular abnormalities. Clinical features vary widely in onset from infancy to late adulthood and often include asymptomatic periods, intermittent gross hematuria, and progression to nephritic syndrome and chronic kidney disease, frequently resulting in end-stage renal disease (ESRD) between 16-35 years of age. Sensorineural hearing loss and ocular findings such as retinopathy and anterior lenticonus are also characteristic. A mnemonic is provided to help remember the key symptoms: \"Patients with Alport syndrome can't pee, can't see, can't hear a bee.\"",{"@graph":69,"@context":105},[70,84],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/glomerular-diseases-part-3/26594/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/glomerular-diseases-part-3/26594.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-20","2026-05-08",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction","https://schema.org",{"og:url":107,"og:type":108,"og:title":65,"og:site_name":95,"og:description":67},"https://docshare.wps.com/document/glomerular-diseases-part-3/26594","article",{"robots":110,"canonical":107},"index,follow",{"doc_id":112,"site_id":62},26594,1778199054,{"code":4,"msg":5,"data":115},{"doc_id":112,"user_id":116,"nickname":92,"user_avatar":117,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":66,"file_id":118,"file_url":119,"file_type":120,"file_size":121,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":122,"language":123,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":66,"faqs":66,"seo_title":124,"seo_description":67,"update_tm":113,"read_time":125},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","cbCaisoSVLMyLL3u","https://ap.wps.com/l/cbCaisoSVLMyLL3u","pdf",1977122,48,"English","Glomerular Diseases Part 3 | PDF",121]