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Results show 383,241 new cases and 81,679 deaths globally in 2021, alongside 2,975,183 prevalent cases and 4,855,780 disability-adjusted life years, with marked regional SDI disparities. Over three decades, incidence and prevalence increased while mortality and disability declined, and breast cancer remained the most prevalent malignancy among AYA women.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/global-trends-in-adolescent-and-young-adult-female-cancer-burden-1990-2021-original-research-key-findings-and-implications/331483/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/global-trends-in-adolescent-and-young-adult-female-cancer-burden-1990-2021-original-research-key-findings-and-implications/331483.png","ImageObject",300,407,{"name":42,"@type":43},"Skyler","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-03","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What age range defines adolescent and young adult (AYA) cancer in the study?","Question",{"text":63,"@type":64},"AYA cancer is defined as cancer diagnosed between ages 15 and 39 years.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which female cancers are included in the burden analysis?",{"text":68,"@type":64},"The analysis covers breast, ovarian, uterine, and cervical cancers among females.",{"name":70,"@type":61,"acceptedAnswer":71},"What major global trend is reported for incidence and mortality from 1990 to 2021?",{"text":72,"@type":64},"Age-standardized incidence and prevalence increased over the past three decades, while age-standardized mortality and disability-adjusted rates declined.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},331483,1790069807,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":112,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":113,"slug":114},8,30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":112,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":124,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},2336464648746,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","ORIGINAL RESEARCH  \nGlobal trends in adolescent and young adult female cancer burden, 1990-2021: insights from the Global Burden of Disease study  \nZ. Huang1y, J. Wang1y, H. Liu2y, B. Wang1, M. Qi1, Z. Lyu2 􀀂 & H. Liu1 􀀂  \n1The Second Surgical Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin; 2Department of Epidemiology and Biostatistics, Key Laboratory of Molecular Cancer Epidemiology, Key Laboratory of Prevention and Control of Human Major Diseases, Ministry of Education, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China  \nAvailable online xxx  \nBackground: The impact of breast carcinoma and genital tract malignancy on the physical and mental health, especially reproductive function, of women aged 15-39 years in the adolescent and young adult (AYA) group is significant. This research aims to analyze the burden of AYA female cancer in various regions and countries globally from 1990 to 2021 . Materials and methods: Epidemiological data were sourced from the Global Burden of Disease (GBD) study 2021 . The study analyzed data on female cancers (breast, ovarian, uterine, and cervical) to assess disease burden across different ages, years, and locations, encompassing 21 GBD regions, 195 countries, and five sociodemographic index (SDI) regions. Results: In 2021, AYA female cancer saw 383 241 new cases and 81 679 deaths globally, with 2 975 183 prevalent cases and 4 855 780 disability-adjusted life years. In 2021, Central Latin America recorded the highest age-standardized incidence (ASIR) and prevalence rates (ASPR), whereas South sub-Saharan Africa had the highest age-standardized mortality (ASMR) and disability rates (ASDR) . Nations with high SDI typically exhibited elevated ASIR and ASPR, whereas ASMR and ASDR demonstrated inverse patterns. Over the past three decades, ASIR and ASPR of female cancers among AYA women have increased globally. In contrast, the ASMR and ASDR have demonstrated a declining trend. Notably, breast cancer emerged as the most prevalent malignancy among AYA women.  \nConclusions: Over the past three decades, the ASIR and ASPR of AYA female cancers have consistently increased, significantly burdening this demographic. Additionally, pronounced disparities are evident across different regions and countries, with AYA women in low SDI environments experiencing poorer prognoses compared to their counterparts in high SDI environments. Consequently, it is imperative to enhance interregional collaboration and communication to optimize the overall prognosis of AYA female cancers.  \nKey words: adolescents and young adults, female cancer, global disease burden, sociodemographic index, average annual percent change  \nINTRODUCTION  \nAdolescent and young adult (AYA) cancer is generally defined as cancer diagnosed between ages 15 and 39 years.1 Among all cancer, approximately 500 000 cases belong to this specific group.2 Compared to older cancer patients, AYAs are more likely to possess genetic  \n*Correspondence to: Prof. Hong Liu, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. Tel: þ86 18622221169  \nE-mail: [liuhong_submit@tjmuch.com](liuhong_submit@tjmuch.com) (H. Liu).  \nDr Zhangyan Lyu, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. Tel: þ86 17710663549  \nE-mail: [lyuzhangyan@tmu.edu.cn](lyuzhangyan@tmu.edu.cn) (Z. Lyu).  \nyThese authors contributed equally to this work and shared the first authorship.  \n2059-7029/© 2024 The Author(s). Published by Elsevier Ltd on behalf of European Society for Medical Oncology. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/)).  \npredispositi","cbCailrzwQRY7J1i","https://ap.wps.com/l/cbCailrzwQRY7J1i","pdf",3553712,"English","# Background\n# Materials and methods\n# Results\n## Global 2021 burden and regional disparities\n## Time trends (1990-2021)\n# Conclusions\n# Key words\n# Introduction","[{\"question\":\"What age range defines adolescent and young adult (AYA) cancer in the study?\",\"answer\":\"AYA cancer is defined as cancer diagnosed between ages 15 and 39 years.\"},{\"question\":\"Which female cancers are included in the burden analysis?\",\"answer\":\"The analysis covers breast, ovarian, uterine, and cervical cancers among females.\"},{\"question\":\"What major global trend is reported for incidence and mortality from 1990 to 2021?\",\"answer\":\"Age-standardized incidence and prevalence increased over the past three decades, while age-standardized mortality and disability-adjusted rates declined.\"}]","Global trends in adolescent and young adult female cancer burden, 1990-2021 - Original Research - Key findings and implications | PDF",1789993487,25]