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Incidence, mortality, and disability-adjusted life years (DALYs) were analyzed by sex and age group, and stratified by sociodemographic index (SDI) quintiles. Age-period-cohort models assessed prevalence, incidence, mortality, and DALY patterns, while forecasting models predicted changes across pediatric age groups. Overall, global disease burden declined, while future childhood cancer projections rose slightly between 2020 and 2040.",{"@graph":69,"@context":127},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/global-regional-and-national-burdens-of-cancer-in-children-aged-zero-to-nine-years-from-1990-to-2019/330733/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/global-regional-and-national-burdens-of-cancer-in-children-aged-zero-to-nine-years-from-1990-to-2019/330733.png","ImageObject",300,407,{"name":92,"@type":93},"Hazel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119,123],{"name":110,"@type":111,"acceptedAnswer":112},"What population and time period does the study focus on?","Question",{"text":113,"@type":114},"The study examines children aged zero to nine years over 1990–2019, assessing cancer burden trends across global, regional, and national settings.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which cancer burden metrics are analyzed?",{"text":118,"@type":114},"Incidence, mortality, and disability-adjusted life years (DALYs) are analyzed, including rates by sex and age group.",{"name":120,"@type":111,"acceptedAnswer":121},"What overall trend was found from 1990 to 2019?",{"text":122,"@type":114},"Cancer disease burden in children aged zero to nine years decreased significantly globally from 1990 to 2019.",{"name":124,"@type":111,"acceptedAnswer":125},"How did the study’s prediction for 2020 to 2040 change?",{"text":126,"@type":114},"The overall prediction of childhood cancer increased slightly from 2020 to 2040, despite the declining burden observed in the historical period.","https://schema.org",{"og:url":83,"og:type":129,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":131,"canonical":83},"index,follow",{"doc_id":133,"site_id":62},330733,1790380743,{"code":4,"msg":5,"data":136},{"doc_id":133,"user_id":137,"nickname":92,"user_avatar":138,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":139,"file_id":140,"file_url":141,"file_type":142,"file_size":143,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":144,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":67,"update_tm":148,"read_time":31,"preview_page_count":4},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","Electronic  \nThe online  \nsupplementary material:  \nversion of this article contains supplementary material.  \n© 2024 The Author(s)  \nCite as: Wang P, Huang S, Shi X, Xu H, Wang R, Peng J, Chen Q, Zhang W, Shi L, Zhou X, Tang X. Global, regional, and national burdens of cancers in children aged zero to nine years from 1990 to 2019. J Glob Health 2024;14:04104 .  \nGlobal, regional, and national burdens of cancer in children aged zero to nine years from 1990 to 2019  \nPing Wang1,2*, Shu Huang3,4*, Xiaomin Shi1,2*, Huan Xu1,2*, Ruiyu Wang1,2, Jieyu Peng1,2, Qi Chen1,2, Wei Zhang1,2, Lei Shi1,2, Xian Zhou1,2, Xiaowei Tang1,2†  \n1Department of Gastroenterology, Affiliated Hospital of Southwest Medical University, Luzhou, China 2Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, China 3Department of Gastroenterology, Lianshui County People’ Hospital, Huaian, China  \n4Department of Gastroenterology, Lianshui People’ Hospital of Kangda College Affiliated to Nanjing Medical University, Huaian, China  \n*Joint first authorship.  \n†Joint senior authorship.  \nCorrespondence to:  \nXiaowei Tang  \nDepartment of Gastroenterology, the Affiliated Hospital of Southwest Medical University  \nStreet Taiping No.25, Luzhou China [solitude5834@hotmail.com](solitude5834@hotmail.com)  \nBackground The description of long-term trends in the cancer burden among children aged zero to nine years from 1990 to 2019 reveals significant changes in children’s health. It helps in resource allocation and health policy planning. We analysed data on the incidence, mortality, and disability-adjusted life years (DALYs) by sex and age group in children aged zero to nine.  \nMethods Estimates of DALYs for children aged zero to nine years, appeared as part of the Global Burden of Diseases, Injuries, and Risk Factor Study 2019, by age, sex, and location for 1990–2019. We also provided estimations by the sociodemographic index (SDI) quintile, a systematic measure to indicate educational attainment, income per capita, and total fertility rate for those younger than 25 years. We used age-period-cohort models to investigate paediatric cancers prevalence, incidence, mortality, and DALYs rates and auto-regressive integrated moving average models to predict cancer in children of different age groups in males and females.  \nResults A total of 6 224 010 DALY numbers for cancer cases occurred globally in 2019 among children aged zero to nine years. Additionally, the incidence of paediatric cancers in 2019 in the middle SDI countries was the highest, including 60 662 cases, and the highest mortality and DALYs cases of paediatric cancers were in the low SDI countries (25 502 and 2 199 790) . The joinpoint regression analysis revealed that the trend of total cancer burden in age-standardised mortality rates and age-standardised DALYs rates showed a significant decrease with an average annual percentage change of –2.10 and –2.03 from 1990 to 2019. Furthermore, the paediatric cancer spectrum was changing. Other malignant neoplasms and other leukaemia were the major components of cancer in all age groups of children.  \nConclusions The disease burden in children aged zero to nine years decreased significantly globally from 1990 to 2019. However, the overall prediction of childhood cancer increased slightly from 2020 to 2040. Our findings may help guide investments and inform policies. This highlights the necessity to improve current treatment measures and establish effective prevention strategies to reduce the cancer burden among children aged zero to nine years.  \nCancer is the second leading cause of mortality worldwide and is currently a major threat to global development [1]. Children with cancer often die without a timely and accurate diagnosis and treatment, and there are no evidence-based and risk-reduction tactics available to improve outcomes [2]. A recent study based on the Global Burden of Diseases, Injuries, and Risk Factor Study 2019 (GBD 2019)  \n","cbCaigZWbFBUfSrt","https://ap.wps.com/l/cbCaigZWbFBUfSrt","pdf",1627943,"English","# Background\n## Methods\n## Results\n## Conclusions","[{\"question\":\"What population and time period does the study focus on?\",\"answer\":\"The study examines children aged zero to nine years over 1990–2019, assessing cancer burden trends across global, regional, and national settings.\"},{\"question\":\"Which cancer burden metrics are analyzed?\",\"answer\":\"Incidence, mortality, and disability-adjusted life years (DALYs) are analyzed, including rates by sex and age group.\"},{\"question\":\"What overall trend was found from 1990 to 2019?\",\"answer\":\"Cancer disease burden in children aged zero to nine years decreased significantly globally from 1990 to 2019.\"},{\"question\":\"How did the study’s prediction for 2020 to 2040 change?\",\"answer\":\"The overall prediction of childhood cancer increased slightly from 2020 to 2040, despite the declining burden observed in the historical period.\"}]","Global, regional, and national burdens of cancer in children aged zero to nine years from 1990 to 2019 | PDF",1789989869]