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Early screening enables timely detection and better surgical and treatment opportunities, improving outcomes.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"What are the main categories of early gastric cancer screening methods?",{"text":67,"@type":63},"The article identifies three predominant categories: imaging screening, endoscopic screening, and serum biomarker screening.",{"name":69,"@type":60,"acceptedAnswer":70},"What screening options are included within imaging, endoscopy, and biomarker approaches?",{"text":71,"@type":63},"Imaging includes upper gastrointestinal barium meal, MDCT, MRI, and ultrasonography. Endoscopy covers white light endoscopy, chromoendoscopy, computed virtual chromoendoscopy, and other advanced endoscopic techniques. Biomarkers include conventional markers (e.g., CEA, CA19-9, CA72-4) and emerging markers such as peptides, DNA alterations, and noncoding RNAs.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},342760,1790141860,{"code":4,"msg":81,"data":82},"success",[83,87,91,95,100,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":84,"show_sort_weight":85,"slug":86},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":88,"show_sort_weight":89,"slug":90},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":92,"show_sort_weight":93,"slug":94},"Exam",70,"exam",{"id":96,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},5,"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":96,"slug":129},19,"General","general",{"code":4,"msg":81,"data":131},{"doc_id":78,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":22,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":117,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":103},4810365810221,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Review  \nIvyspring  \nInternational Publisher  \nJournal of Cancer  \n2024; 15(10): 3045-3064. doi: 10.7150/jca.95311  \nGlobal progress and future prospects of early gastric cancer screening  \nYixiao Huang1,2*, Yongfu Shao1,2*, Xuan Yu2, Chujia Chen2, Junming Guo2􀀍, Guoliang Ye1,3􀀍  \n1. Department of Gastroenterology, the First Affiliated Hospital of Ningbo University, Ningbo 315020, China.  \n2. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo 315211, China.  \n3. Institute of Digestive Disease of Ningbo University, Ningbo 315020, China.  \n* These authors contributed equally to this work and should be regarded as co-first authors.  \n􀀍 Corresponding authors: Guoliang Ye, Institute of Digestive Disease of Ningbo University & Department of Gastroenterology, the First Affiliated Hospital of Ningbo University, Ningbo 315020, China. Tel: +86-574-87035171; Fax: +[86-574-87380487. E-mail: yeguoliang@nbu.edu.cn or ndfyygl@126.com](86-574-87380487. E-mail: yeguoliang@nbu.edu.cn or ndfyygl@126.com); or Junming Guo, Health Science Center, Ningbo University, Ningbo 315211, China. Tel: +86-574-87600756; Fax: +86-574-87608638; [E-mail: guojunming@nbu.edu.cn](E-mail: guojunming@nbu.edu.cn).© The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/)). See [http://ivyspring.com/terms](http://ivyspring.com/terms) for full terms and conditions.  \nReceived: 2024.02.14; Accepted: 2024.03.21; Published: 2024.04.08  \nAbstract  \nGastric cancer is a prevalent malignancy that poses a serious threat to global health. Despite advances in medical technologies, screening methods, and public awareness, gastric cancer remains a significant cause of morbidity and mortality worldwide. Early gastric cancer frequently does not present with characteristic symptoms, while advanced stage disease is characterized by a dismal prognosis. As such, early screening in gastric cancer is of great importance. In recent years, advances have been made globally in both clinical and basic research for the screening of early gastric cancer. The current predominant screening methods for early gastric cancer include imaging screening, endoscopic screening and serum biomarker screening. Imaging screening encompasses upper gastrointestinal barium meal, multidimensional spiral computed tomography (MDCT), Magnetic resonance imaging (MRI), and ultrasonography. Endoscopic screening methods include white light endoscopy, chromoendoscopy, computed virtual chromoendoscopy, and other endoscopic techniques like endocytoscopy, confocal laser endomicroscopy, optical coherence tomography and so on. Biomarkers screening involves the assessment of conventional biomarkers such as CEA, CA19-9 and CA72-4 as well as more emerging biomarkers such as peptides (PG, G-17, GCAA, TAAs and others), DNA (cfDNA, DNA methylation, MSI), noncoding RNA (miRNA, lncRNA, circRNA, and tsRNA) and others. Each screening method has its strengths and limitations. This article systematically summarizes worldwide progress and future development of early gastric cancer screening methods to provide new perspectives and approaches for early diagnostic and treatment advancements in gastric cancer worldwide.  \nKeywords: Gastric cancer, Early screening, Imaging, Endoscopy, Biomarkers, Noncoding RNA  \nIntroduction  \nGastric cancer is a prevalent gastrointestinal tumor, with the fifth and third highest incidence and mortality rates for malignant tumors, respectively [1] . Objective statistics indicate that over 1 million cases were recorded in 2020 worldwide, resulting in over 768,000 fatalities [2] . The incidence of gastric cancer is particularly high in East Asia, where it reaches up to 45.7 per 100,000 people (Figure 1) [2] . In recent years, gastric cancer has remained a significant challenge for ","cbCaikQrrvXwrXNj","https://ap.wps.com/l/cbCaikQrrvXwrXNj","pdf",4898004,"English","# Abstract\n# Introduction","[{\"question\":\"Why is early gastric cancer screening important?\",\"answer\":\"Early gastric cancer frequently shows no clear symptoms, so diagnosis is often delayed until the disease is advanced. Early screening enables timely detection and better surgical and treatment opportunities, improving outcomes.\"},{\"question\":\"What are the main categories of early gastric cancer screening methods?\",\"answer\":\"The article identifies three predominant categories: imaging screening, endoscopic screening, and serum biomarker screening.\"},{\"question\":\"What screening options are included within imaging, endoscopy, and biomarker approaches?\",\"answer\":\"Imaging includes upper gastrointestinal barium meal, MDCT, MRI, and ultrasonography. Endoscopy covers white light endoscopy, chromoendoscopy, computed virtual chromoendoscopy, and other advanced endoscopic techniques. Biomarkers include conventional markers (e.g., CEA, CA19-9, CA72-4) and emerging markers such as peptides, DNA alterations, and noncoding RNAs.\"}]","Global progress and future prospects of early gastric cancer screening | PDF",1790048063]