[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-332594-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-332594-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","global-obesity-epidemic-and-rising-incidence-of-early-onset-cancers","Global obesity epidemic and rising incidence of early-onset cancers","","Background: Incidence of early-onset cancers across multiple organ sites has risen worldwide in recent decades. Methods: Incidence data for 21 common cancers among people aged 25–49 from 42 countries (2000–2012) were analyzed, relating changes in overweight and obesity prevalence to cancer incidence with time lags of 0–15 years. Results: Increases were observed for several obesity-related and non-obesity-related cancers, with positive correlations for key obesity-related sites. Conclusions: Early-onset colon, rectal, pancreatic, and kidney cancer increases may be partly driven by excess body weight, while other cancers likely reflect additional factors.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/global-obesity-epidemic-and-rising-incidence-of-early-onset-cancers/332594/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/global-obesity-epidemic-and-rising-incidence-of-early-onset-cancers/332594.png","ImageObject",300,407,{"name":42,"@type":43},"Rowan","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-26","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the study aiming to explain?","Question",{"text":63,"@type":64},"The study examined whether the worldwide increase in early-onset cancers could be explained by trends in obesity.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were the data sources and study approach defined?",{"text":68,"@type":64},"Incidence data for 21 cancers among ages 25–49 (2000–2012) were taken from the Cancer Incidence in Five Continents database, and overweight/obesity prevalence estimates came from the Non-communicable Disease Risk Factor Collaboration.",{"name":70,"@type":61,"acceptedAnswer":71},"Which cancer sites showed positive correlations with overweight and obesity?",{"text":72,"@type":64},"For obesity-related cancers with increased incidence, cancer incidence changes were positively correlated with changes in overweight and obesity prevalence, including colon, rectum, pancreas, and kidney when a 15-year lag was considered.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},332594,1790197264,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},1099514067415,"https://ap-avatar.wpscdn.com/avatar/100002539d78ffe74a7?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779092875211072502","Electronic  \nThe online  \nsupplementary material:  \nversion of this article contains supplementary material.  \n© 2024 The Author(s)  \nCite as: Chen J, Dalerba P, Terry MB, Yang W. Global obesity epidemic and rising incidence of early-onset cancers. J Glob Health 2024;14:04025.  \nGlobal obesity epidemic and rising incidence of early-onset cancers  \nJianjiu Chen1,  \nPiero Dalerba2,3,4,5,6,7  \n, Mary Beth Terry1,2,  \nWan Yang1,2  \n1Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA  \n2Herbert Irving Comprehensive Cancer Center (HICCC), Columbia University Irving Medical Center, New York, New York, USA 3Department of Pathology and Cell Biology, Columbia University, New York, New York, USA 4Division of Digestive and Liver Disorders, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA  \n5Digestive and Liver Disease Research Center (DLDRC), Columbia University Irving Medical Center, New York, New York, USA  \n6Columbia Stem Cell Initiative (CSCI), Columbia University Irving Medical Center, New York, New York, USA  \n7Center for Discovery and Innovation (CDI), Hackensack Meridian Health, Nutley, New Jersey, USA  \nCorrespondence to:  \nJianjiu Chen  \nDepartment of Epidemiology, Mailman School of Public Health, Columbia University 722 West 168th Street, Room 517, New York, New York  \nUSA  \n[chenjianjiu@gmail.com](chenjianjiu@gmail.com)  \nWan Yang  \nDepartment of Epidemiology, Mailman School of Public Health, Columbia University; Herbert Irving Comprehensive Cancer Center (HICCC), Columbia University Irving Medical Center  \n722 West 168th Street, Room 514, New York,  \nNew York  \nUSA[wy2202@cumc.columbia.edu](wy2202@cumc.columbia.edu)  \nBackground Incidence of early-onset cancers at multiple organ sites has increased worldwide in recent decades. We investigated whether such increasing trends could be explained by trends in obesity.  \nMethods We obtained incidence data for 21 common cancers among 25–49-year-olds during 2000–2012 in 42 countries from the Cancer Incidence in Five Continents database. Nine cancers we examined have been classified as obesity-related by the International Agency for Research on Cancer. Estimates of overweight and obesity prevalence came from the Non-communicable Disease Risk Factor Collaboration. Using country-level data, we examined whether changes in the prevalence of overweight and obesity combined were correlated with changes in cancer incidence, after accounting for various time lags (0–15 years) between exposure and cancer diagnosis. To test the validity of our approach, we conducted negative control analyses (using non-obesity-related cancers as the outcome variable, and per-capita gross national income as the exposure variable), and sensitivity and supplemental analyses using alternative data streams or processing.  \nResults We found increased incidence for six of nine obesity-related and seven of twelve non-obesity-related cancers in 25–49-year-olds. These increases were more predominant in Western countries (particularly Australia, the USA, Canada, Norway, the Netherlands, and Lithuania). For four obesity-related cancers displaying increased incidence (colon, rectum, pancreas, kidney), changes in cancer incidence were positively correlated with changes in overweight and obesity prevalence. When accounting for a 15-year lag, the estimated correlation was 0.27 (95% confidence interval (CI) = −0 .04, 0.53; P = 0 .090) for colon cancer, 0.33 (95% CI = 0 .02, 0 .58; P = 0 .036) for rectal cancer, 0.39 (95% CI = 0 .08, 0.64; P = 0 .018) for pancreatic cancer, and 0.22 (95% CI = −0 . 10, 0 .50; P = 0 . 173) for kidney cancer. Similar correlations were found in the sensitivity and supplemental analyses. We did not find similar correlations with excess body weight for the non-obesity-related early-onset cancers, nor correlations with per-capita gross national income for any cancer types, in the negative control analyses. ","cbCaitiBTU5W8ob8","https://ap.wps.com/l/cbCaitiBTU5W8ob8","pdf",3711452,11,"English","# Background\n# Methods\n# Results\n# Conclusions","[{\"question\":\"What was the study aiming to explain?\",\"answer\":\"The study examined whether the worldwide increase in early-onset cancers could be explained by trends in obesity.\"},{\"question\":\"How were the data sources and study approach defined?\",\"answer\":\"Incidence data for 21 cancers among ages 25–49 (2000–2012) were taken from the Cancer Incidence in Five Continents database, and overweight/obesity prevalence estimates came from the Non-communicable Disease Risk Factor Collaboration.\"},{\"question\":\"Which cancer sites showed positive correlations with overweight and obesity?\",\"answer\":\"For obesity-related cancers with increased incidence, cancer incidence changes were positively correlated with changes in overweight and obesity prevalence, including colon, rectum, pancreas, and kidney when a 15-year lag was considered.\"}]","Global obesity epidemic and rising incidence of early-onset cancers | PDF",1789998869,28]