[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-366587-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-366587-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","global-lifetime-estimates-of-expected-and-preventable-gastric-cancers-across-185-countries","Global lifetime estimates of expected and preventable gastric cancers across 185 countries","","Chronic Helicobacter pylori infection is modeled as a modifiable driver of gastric cancer burden across birth cohorts from 2008–2017. Expected lifetime cases in 185 countries are estimated by combining GLOBOCAN 2022 age-specific incidence with United Nations cohort mortality projections. Globally, 15.6 million cases are expected, 76% attributable to H. pylori, with two-thirds concentrated in Asia. Demographic shifts predict substantial future increases in lower-incidence regions, especially sub-Saharan Africa, supporting population-based screen-and-treat prevention.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/global-lifetime-estimates-of-expected-and-preventable-gastric-cancers-across-185-countries/366587/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/global-lifetime-estimates-of-expected-and-preventable-gastric-cancers-across-185-countries/366587.png","ImageObject",300,407,{"name":42,"@type":43},"Kurz","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-24","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",15,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main goal of the study on gastric cancer burden?","Question",{"text":63,"@type":64},"To project the future lifetime burden of gastric cancer, including the portion attributable to Helicobacter pylori, to support policy planning for prevention strategies.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How are expected gastric cancer cases estimated across the 185 countries?",{"text":68,"@type":64},"By combining national age-specific incidence rates from GLOBOCAN 2022 with cohort-specific mortality rates from United Nations demographic projections for the 2008–2017 birth cohorts.",{"name":70,"@type":61,"acceptedAnswer":71},"What prevention approach does the paper emphasize for reducing gastric cancer risk?",{"text":72,"@type":64},"Implementing population-based H. pylori screen-and-treat strategies, reflecting that most gastric cancers can be prevented by treating the infection with antibiotics and proton pump inhibitors.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},366587,1790218114,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":99},2336478945635,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","nature medicine  \nArticle [https://doi.org/10.1038/s41591-025-03793-6](https://doi.org/10.1038/s41591-025-03793-6)  \nGlobal lifetime estimates of expected and preventable gastric cancers across 185 countries  \nReceived: 11 December 2024  \nAccepted: 23 May 2025  \n\n| Published online: 7 July 2025 |\n| --- |\n|  Check for updates |\n\nJin Young Park  1 , Damien Georges  1, Catharina J. Alberts1,2,3, Freddie Bray4, Gary Clifford  1 & Iacopo Baussano  1   \nChronic infection with Helicobacter pylori is a modifiable cause of gastric cancer. To assist policymakers in advocating for and planning prevention strategies, we projected the future burden of gastric cancer, including that attributable toH. pylori, among a cohort of young people born in 2008–2017. Expected gastric cancer cases, in the absence of intervention, were quantified in 185 countries by combining national age-specific incidence rates from GLOBOCAN 2022 and cohort-specific mortality rates from the United Nations’demographic projections. Globally, 15.6 million (95% uncertainty interval 14.0–17.3 million) lifetime gastric cancer cases are expected within these birth cohorts, 76% of which are attributable to H. pylori. Two-thirds of cases will be concentrated in Asia, followed by the Americasand Africa. Whereas 58% of cases are expected in traditionally high-incidence areas for gastric cancer, 42% of cases are expected to occur in lower-incidence areas owing to demographic changes, particularly in sub-Saharan Africa, where the future burden could be six times greater than estimated in 2022. A shift in focus toward the life course of today’s young people and their prospects of developing gastric cancer, with or without effective interventions, underscores the need for greater investment in gastric cancer prevention, includingthe implementation of population-based H. pylori screen-and-treat strategies.  \nAlthough some higher-resource countries, notably in East Asia, have put in place organized early detection programs1,2, gastric cancer remains the fifth most common cause of cancer death worldwide3, and thereis evidence that the disease will remain an important public health problem for the foreseeable future unless effective measures are implemented4. Long considered an ‘unplanned triumph’ of primary prevention5, gastric cancer has been prone to underinvestment relative to other infection-related cancers, such as cervical or liver cancer3,6,7. Of note, gastric cancer incidence rates at younger ages (\u003C50 years) are increasing in both low-and high-incidence populations8–11, which may,  \nin turn, result ina deceleration or reversal of the long-term declinesin incidence rates. Further, the numbers of gastric cancer cases and deaths are projected to increase in the next decades through population aging and growth irrespective of overall trends4.  \nMost gastric cancers, especially noncardia gastric cancer (NCGC), are caused by chronic infection with Helicobacter pylori12,13 and can be prevented by treatment of the infection with a combination of antibiotics and proton pump inhibitors. A systematic review of the available randomized controlled trials and observational studies showed that studies of different designs consistently found that  \n1Early Detection, Prevention and Infections Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France. 2Department of Epidemiology and Data Science, Amsterdam University Medical Center, Amsterdam, the Netherlands. 3Department of Infectious Diseases, Public Health Service (GGD) of Amsterdam, Amsterdam, the Netherlands. 4Cancer Surveillance Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.  \n[e-mail:](e-mail: parkjy@iarc.who.int)[ parkjy@iarc.who.int](e-mail: parkjy@iarc.who.int); [baussanoi@iarc.who.int](baussanoi@iarc.who.int)  \nTable 1 | Estimates of gastric cancer incidence in individuals born between 2008 and 2017  \nCategory Number of  \npeople at risk  \nExpected gastric cancer cases in the absence ","cbCaih4LBgnSt5YZ","https://ap.wps.com/l/cbCaih4LBgnSt5YZ","pdf",3050724,24,"English","# Overview and purpose\n# Methods for projecting lifetime burden\n# Global and regional burden of expected cases\n# Prevention implications: H. pylori screen-and-treat\n# Evidence base on controllability and interventions\n# Table 1: Incidence estimates by region","[{\"question\":\"What is the main goal of the study on gastric cancer burden?\",\"answer\":\"To project the future lifetime burden of gastric cancer, including the portion attributable to Helicobacter pylori, to support policy planning for prevention strategies.\"},{\"question\":\"How are expected gastric cancer cases estimated across the 185 countries?\",\"answer\":\"By combining national age-specific incidence rates from GLOBOCAN 2022 with cohort-specific mortality rates from United Nations demographic projections for the 2008–2017 birth cohorts.\"},{\"question\":\"What prevention approach does the paper emphasize for reducing gastric cancer risk?\",\"answer\":\"Implementing population-based H. pylori screen-and-treat strategies, reflecting that most gastric cancers can be prevented by treating the infection with antibiotics and proton pump inhibitors.\"}]","Global lifetime estimates of expected and preventable gastric cancers across 185 countries | PDF",1790166268]