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This study quantifies the global burden and temporal trends of AYA cancer, emphasizing socioeconomic disparities, to support evidence-informed global cancer control strategies. Methods AYA cancer was defined as cancer in individuals aged 15–39 and analyzed using Global Burden of Disease (GBD) 2021 data and GLOBOCAN 2022. Burden was assessed by age, sex, geography, and Human Development Index (HDI), including incidence, mortality, and temporal trends using age-standardized rates and average annual percent change.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/global-cancer-statistics-for-adolescents-and-young-adults-population-based-study/329198/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/global-cancer-statistics-for-adolescents-and-young-adults-population-based-study/329198.png","ImageObject",300,407,{"name":92,"@type":93},"Sage","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How is AYA cancer defined in this study?","Question",{"text":112,"@type":113},"The study defines AYA cancer as cancer occurring in individuals aged 15–39.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which data sources are used to estimate global burden and trends?",{"text":117,"@type":113},"Estimates are based on the Global Burden of Disease (GBD) 2021 study and the Global Cancer Observatory (GLOBOCAN) 2022 project.",{"name":119,"@type":110,"acceptedAnswer":120},"What disparities by Human Development Index (HDI) were observed?",{"text":121,"@type":113},"Higher-HDI countries showed higher incidence, while lower-HDI countries faced disproportionately higher mortality burden despite lower incidence.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},329198,1790442194,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},687197207057,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Li etal. Journal of Hematology & Oncology (2024) 17:99 [https://doi.org/10.1186/s13045-024-01623-9](https://doi.org/10.1186/s13045-024-01623-9)  \nJournal of Hematology & Oncology  \n RESEARCH Open Access  \nGlobal cancer statistics for adolescents  \nand young adults: population based study  \nWangzhong Li1,2, Hengrui Liang1,2, Wei Wang1,2,3, Jun Liu1,2,3, Xiwen Liu1,2, Shen Lao1,2, Wenhua Liang1,2,3* and Jianxing He 1,2,3*  \nAbstract  \nBackground Accurate and up-to-date estimates of the global cancer burden in adolescents and young adults (AYA) are scarce. This study aims to assess the global burden and trends of AYA cancer, with a focus on socioeconomic disparities, to inform global cancer control strategies.  \nMethods AYA cancer, defined as cancer occurring in individuals aged 15–39, was analyzed using data  \nfrom the Global Burden of Disease (GBD) 2021 study and the Global Cancer Observatory (GLOBOCAN) 2022 project. We examined the global burden by age, sex, geographic location, and Human Development Index (HDI), as well as its temporal trends. Primary outcomes included age-standardized incidence and mortality rates (ASIR, ASMR) and the average annual percent change (AAPC) .  \nResults In 2022, an estimated 1,300,196 incidental cases and 377,621 cancer-related deaths occurred among AYAs worldwide, with an ASIR of 40.3 per 100,000 and an ASMR of 11.8 per 100,000 . The most common cancers were breast, thyroid, and cervical, while the leading causes of death were breast, cervical, and leukemia. The incidence and mortality were disproportionately higher among females (ASIR: 52.9 for females vs. 28.3 for males; ASMR: 13.1 for females vs. 10.6 for males) . Countries with higher HDI experienced a higher incidence of AYA cancers (ASIR: 32.0 [low HDI] vs. 54.8 [very high HDI]), while countries with lower HDI faced a disproportionately higher mortality burden (ASMR: 17.2 [low HDI] vs. 8.4 [very high HDI]) despite their relatively low incidence. Disproportionality and regression measures highlighted significant HDI-related inequalities. AYA cancer incidence was stable from 2000 to 2011 (AAPC: − 0 . 04) but increased from 2012 to 2021 (AAPC: 0 . 53), driven by growing gonadal and colorectal cancers. Mortality decreased substantially from 2000 to 2011 (AAPC: − 1 . 64), but the decline slowed from 2012 (AAPC: − 0 . 32) probably due to increased deaths from gonadal cancers. These trends varied by sex, cancer type, geography, and HDI.  \nConclusion AYA cancers present a significant and growing global burden, with marked disparities across sex, geographic locations, and HDI levels. Policymakers should prioritize equitable resource allocation and implement targeted interventions to reduce these inequalities, particularly in low-HDI regions and with regard to gonadal cancers. Keywords Adolescents and young adults, Cancer, Incidence, Mortality, Global analysis, Trend, Disparities  \n*Correspondence: Wenhua Liang [liangwh1987@163.com](liangwh1987@163.com)[ ](liangwh1987@163.com)Jianxing He [drjianxing.he@gmail.com](drjianxing.he@gmail.com)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulatio","cbCaicqAxp47vLJK","https://ap.wps.com/l/cbCaicqAxp47vLJK","pdf",7426432,14,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n## Keywords","[{\"question\":\"How is AYA cancer defined in this study?\",\"answer\":\"The study defines AYA cancer as cancer occurring in individuals aged 15–39.\"},{\"question\":\"Which data sources are used to estimate global burden and trends?\",\"answer\":\"Estimates are based on the Global Burden of Disease (GBD) 2021 study and the Global Cancer Observatory (GLOBOCAN) 2022 project.\"},{\"question\":\"What disparities by Human Development Index (HDI) were observed?\",\"answer\":\"Higher-HDI countries showed higher incidence, while lower-HDI countries faced disproportionately higher mortality burden despite lower incidence.\"}]","Global cancer statistics for adolescents and young adults - population based study | PDF",1789983039,35]