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This secondary analysis used age-standardized disability-adjusted life years (DALYs) and mortality from the Global Burden of Disease (GBD) Study 2021, stratified by dietary risk, sex, age, and SDI. Bayesian age-period-cohort modeling projected DALY and mortality trends to 2050, while inequality was evaluated using the slope and concentration indices.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/global-burden-and-trends-analysis-of-common-cancers-attributable-to-dietary-risks-from-1990-to-2021-and-projection-to-2050-a-secondary-analysis-for-the-global-burden-of-disease-study-2021/366916/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/global-burden-and-trends-analysis-of-common-cancers-attributable-to-dietary-risks-from-1990-to-2021-and-projection-to-2050-a-secondary-analysis-for-the-global-burden-of-disease-study-2021/366916.png","ImageObject",300,407,{"name":92,"@type":93},"hdkawk","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-26","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What data and outcomes were used to quantify the burden of diet-related neoplasms?","Question",{"text":112,"@type":113},"The study extracted age-standardized DALYs and mortality rates for DRNs from the GBD Study 2021, categorized by dietary risk, sex, age, and SDI level.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were future trends in DALYs and mortality projected to 2050?",{"text":117,"@type":113},"Projections from 2021 to 2050 were generated using Bayesian age-period-cohort models for DALY and mortality trends.",{"name":119,"@type":110,"acceptedAnswer":120},"Which dietary factors were identified as primary risks for diet-related neoplasms?",{"text":121,"@type":113},"Diets high in red meat and low in whole grains were identified as primary dietary risks for DRNs.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},366916,1791206668,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},3985747859855,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","OPEN ACCESS  \nEDITED BY  \nAsma Saleem Qazi,  \nNational University of Medical Sciences (NUMS), Pakistan  \nREVIEWED BY  \nAbdul Momin Rizwan Ahmad, University of York, United Kingdom Umar Farooq,  \nNational University of Medical Sciences (NUMS), Pakistan  \n*CORRESPONDENCE  \nFan Li  \n [202899@hospital.cqmu.edu.cn](202899@hospital.cqmu.edu.cn)  \n†These authors have contributed equally to this work  \nRECEIVED 29 July 2025  \nREVISED 19 November 2025  \nACCEPTED 25 November 2025  \nPUBLISHED 19 December 2025  \nCITATION  \nWei T, Li Y, Zhang Z, Xu Y, Huang H, Huang Y, Li J, Gong Z, Hu Z, Wang Y,  \nZhang A and Li F (2025) Global burden and trends analysis of common cancers attributable to dietary risks from 1990 to 2021 and projection to 2050: a secondary analysis for the global burden of disease study 2021. Front. Nutr. 12:1673422 .  \ndoi: 10.3389/fnut.2025.1673422  \nCOPYRIGHT  \n© 2025 Wei, Li, Zhang, Xu, Huang, Huang, Li, Gong, Hu, Wang, Zhang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nTYPE Original Research PUBLISHED 19 December 2025 DOI 10.3389/fnut.2025.1673422  \nGlobal burden and trends analysis of common cancers attributable to dietary risks from 1990 to 2021 and projection to 2050: a secondary analysis for the global burden of disease study 2021  \nTingting Wei 1†, Yunhai Li 1†, Ze Zhang 1, Yijing Xu 1, Hongbo Huang 1, Ying Huang 1, Jiaying Li 1, Zheng Gong 1, Zhiqi Hu 1, Yichen Wang 1, Aijie Zhang 2 and Fan Li 1*  \n1Department of Breast and Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China, 2Health Management Center of University Town Hospital Affiliated to Chongqing Medical University, Chongqing, China  \nBackground: Dietary risk factors play crucial roles in the carcinogenesis and progression of cancer. However, the global burden of diet-related neoplasms (DRNs) remains underexplored.  \nMethods: Age-standardized disability-adjusted life years (DALYs) and mortality rates for DRNs were extracted from the Global Burden of Disease (GBD) Study 2021. These were categorized by dietary risk, sex, age, and sociodemographic index (SDI) level. Predictions of DALY and mortality trends from 2021 to 2050 were generated via the Bayesian age-period-cohort models. Crosscountry inequalities were assessed using the slope index of inequality and the concentration index.  \nResults: In 2021, dietary risk contributed to 16.40 million DALYs and 0.67 million deaths from DRNs, including esophageal, stomach, colon and rectum, tracheal, bronchus, and lung, breast, and prostate cancers. Diets high in red meat and low in whole grains were primary dietary risks for DRNs. Globally, the agestandardized DALY and mortality rates related to DRNs have decreased over the past three decades and are projected to continue to decline until 2050. The DRNs burden is particularly heavy for colon and rectal cancer patients, patients in high and high-middle SDI regions, men, and those aged ≥70 years. Crosscountry inequalities reveal that the slope index of inequality rose for DRNs from 262.74 in 1990 to 296.14 in 2021. The concentration index was 0.27 in 1990 and 0.30 in 2021.  \nConclusion: This study revealed significant variations in the burden of DRNs across different age groups, sexes, regions, and countries, emphasizing the potential for tailored cancer screening strategies targeting populations with higher risks of DRNs.  \nKEYWORDS  \nneoplasms, global burden of disease study, dietary risk factors, sociodemographic index, health inequality  \nFrontiers in Nutrition 01 [frontiersin.org](frontiersin.org)  \nIntroduction ","cbCaitIPtujdVV5g","https://ap.wps.com/l/cbCaitIPtujdVV5g","pdf",8310727,13,"English","# Introduction\n## Background and rationale\n# Methods\n## Data sources and stratification\n## Prediction model and projections\n## Inequality assessment\n# Results\n## 2021 burden and major dietary risks\n## Trends from 1990 to 2021 and projections to 2050\n## High-burden groups and inequality findings\n# Conclusion","[{\"question\":\"What data and outcomes were used to quantify the burden of diet-related neoplasms?\",\"answer\":\"The study extracted age-standardized DALYs and mortality rates for DRNs from the GBD Study 2021, categorized by dietary risk, sex, age, and SDI level.\"},{\"question\":\"How were future trends in DALYs and mortality projected to 2050?\",\"answer\":\"Projections from 2021 to 2050 were generated using Bayesian age-period-cohort models for DALY and mortality trends.\"},{\"question\":\"Which dietary factors were identified as primary risks for diet-related neoplasms?\",\"answer\":\"Diets high in red meat and low in whole grains were identified as primary dietary risks for DRNs.\"}]","Global burden and trends analysis of common cancers attributable to dietary risks from 1990 to 2021 and projection to 2050: a secondary analysis for the global burden of disease study 2021 | PDF",1790168214,33]