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A 34-year-old woman presented with progressive thoracolumbar pain, kyphotic deformity, and incomplete spinal cord injury with transient paraplegia. Imaging showed marked L1 collapse, severe canal compromise, and an expansile lytic lesion with paravertebral extension. Definitive posterior-only surgery achieved rapid sensory recovery and ambulatory function within 24 hours.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/giant-cell-tumor-in-the-thoracolumbar-junction-a-case-report/443345/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/giant-cell-tumor-in-the-thoracolumbar-junction-a-case-report/443345.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What symptoms and key imaging findings were reported in the presented case?","Question",{"text":113,"@type":114},"The patient had progressive thoracolumbar pain, kyphotic deformity, and incomplete spinal cord injury with transient paraplegia. Radiographs showed ~90% L1 vertebral collapse with marked regional kyphosis, and MRI demonstrated an expansile lytic L1 lesion with paravertebral extension and severe canal compromise.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What surgical strategy was used to treat the spinal giant cell tumor?",{"text":118,"@type":114},"Definitive treatment used a posterior-only approach with a Schwab type five osteotomy, mesh-cage reconstruction with autograft, and T12–L4 instrumentation.",{"name":120,"@type":111,"acceptedAnswer":121},"How did the patient’s neurological status change after surgery, and what follow-up issues emerged?",{"text":122,"@type":114},"Postoperatively, sensory function below T11 recovered rapidly and motor function was preserved, with regaining ambulation within 24 hours. Follow-up imaging confirmed deformity correction and construct stability, while locoregional recurrence was identified eight months postoperatively.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},443345,1790741088,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":46,"preview_page_count":4},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Review began 11/03/2025  \nReview ended 11/27/2025  \nPublished 12/05/2025  \n© Copyright 2025  \nVillalba-Piña et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CCBY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.98546  \nOpen Access Case Report  \nGiant Cell Tumor in the Thoracolumbar Junction: A Case Report  \nVictor M. Villalba-Piña 1, Javier Gomez-Farias 2, Roxana G. Figueroa-Baca 1 , Felipe Aguilar-Chávez 3  \n1. Department of Orthopedics and Traumatology, Hospital General de Ciudad Juarez, Ciudad Juarez, MEX 2. Department of Neurology, University of Texas Health Science Center at Houston, Houston, USA 3. Department of Orthopedics and Traumatology, Cisne Spine Academy, Star Medical Hospital, Autonomous University of Chihuahua, Chihuahua, MEX  \nCorresponding author: Javier Gomez-Farias, [jgomezfarias@hsph.harvard.edu](jgomezfarias@hsph.harvard.edu)  \nAbstract  \nA giant cell tumor (GCT) of the spine is an uncommon benign bone neoplasm that can behave aggressively and cause neurological compromise. Its rarity and location within load-bearing, neuro-critical anatomy make diagnosis and management particularly complex. A 34-year-old woman presented with progressive thoracolumbar pain, kyphotic deformity, and incomplete spinal cord injury leading to transient paraplegia. Radiographs showed 90% collapse ofthe L1 vertebral body with about 45° regional kyphosis. Magnetic resonance imaging revealed an expansile lytic lesion at L1 with paravertebral extension and severe canal compromise.  \nDefinitive management was achieved through a posterior-only approach using a Schwab type five osteotomy, mesh-cage reconstruction with autograft, and T 12-L4 instrumentation. Postoperatively, the patient showed rapid sensory recovery below T11 and preserved motor function, regaining ambulation within 24 hours. Follow-up imaging confirmed correction of deformity and construct stability. Histopathology demonstrated multinucleated giant cells in a mononuclear stromal background, confirming GCT. Locoregional recurrence was identified eight months postoperatively. This case highlights the value of prompt recognition and meticulous surgical planning in spinal GCT. Early intervention with complete resection and stabilization can restore alignment, prevent permanent neurological deficits, and achieve durable local control. Multidisciplinary management is crucial for optimizing outcomes in these rare but challenging lesions.  \nCategories: Neurosurgery, Oncology, Orthopedics  \nKeywords: giant cell tumor, kyphosis, osteotomy, paraplegia, spinal neoplasms  \nIntroduction  \nSpinal tumors are rare but clinically significant neoplasms that, without treatment, can cause severe neurological morbidity. They are classified based on their relationship to the spinal cord and dura mater as extradural (the most common at 50%), intradural-extramedullary, and intramedullary. The vast majority are metastatic (up to 97% of all vertebral lesions), with those originating from the breast, lung, and prostate being the most frequent [1-4].  \nIn contrast, primary spinal tumors are rare and may arise from the spinal cord, meninges, or bony and softtissue structures. Malignant primary neoplasms include chordoma, chondrosarcoma, Ewing sarcoma, and osteosarcoma, while benign lesions include osteoid osteoma, osteoblastoma, aneurysmal bone cyst, osteochondroma, and giant cell tumor (GCT) [5] .  \nWhen vertebral bodies are involved, lesions may produce vertebral destruction syndrome (VDS), structural instability, deformity, and neurologic compromise from infectious, metabolic, or neoplastic causes. Clinical evaluation should be paired with prognostic scores (Karnofsky, Tomita, Tokuhashi) to gauge function, metastatic burden, and survival, guiding treatment planning [5,6] .  \nAccording to the World Health Organization (WHO)","cbCaiuSSswmc7rK6","https://ap.wps.com/l/cbCaiuSSswmc7rK6","pdf",4612971,"English","# Abstract\n# Introduction\n## Spinal tumor classification and clinical impact\n## Primary spinal tumors and differential diagnoses\n## Vertebral destruction syndrome and prognostic scoring\n## WHO characteristics of giant cell tumor\n## Diagnostic and therapeutic challenges in thoracolumbar GCT\n# How to cite this article\n# Management overview\n# Study aim","[{\"question\":\"What symptoms and key imaging findings were reported in the presented case?\",\"answer\":\"The patient had progressive thoracolumbar pain, kyphotic deformity, and incomplete spinal cord injury with transient paraplegia. Radiographs showed ~90% L1 vertebral collapse with marked regional kyphosis, and MRI demonstrated an expansile lytic L1 lesion with paravertebral extension and severe canal compromise.\"},{\"question\":\"What surgical strategy was used to treat the spinal giant cell tumor?\",\"answer\":\"Definitive treatment used a posterior-only approach with a Schwab type five osteotomy, mesh-cage reconstruction with autograft, and T12–L4 instrumentation.\"},{\"question\":\"How did the patient’s neurological status change after surgery, and what follow-up issues emerged?\",\"answer\":\"Postoperatively, sensory function below T11 recovered rapidly and motor function was preserved, with regaining ambulation within 24 hours. Follow-up imaging confirmed deformity correction and construct stability, while locoregional recurrence was identified eight months postoperatively.\"}]","Giant Cell Tumor in the Thoracolumbar Junction - A Case Report | PDF",1790703735]