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Epidemiologic and genetic findings from the general population and exceptional longevity cohorts indicate attenuated GH/IGF-1 signaling may mediate healthy aging and reduce risk of age-related diseases including cancer, diabetes, dementia, and cardiovascular disease. These results have supported preclinical trials of newly developed and repurposed therapeutics aimed at diminishing GH/IGF-1 signaling to potentially delay aging and associated conditions.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ghigf-1-axis-as-a-gerotherapeutic-target-abstract-citation-id-igaf1221103/424717/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ghigf-1-axis-as-a-gerotherapeutic-target-abstract-citation-id-igaf1221103/424717.png","ImageObject",300,407,{"name":92,"@type":93},"jay","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How is GH/IGF-1 linked to aging in model organisms versus humans?","Question",{"text":112,"@type":113},"In model organisms, GH/IGF-1 is well established as a modulator of aging and longevity. In humans, its role in aging is described as less established.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What evidence suggests attenuated GH/IGF-1 signaling may promote healthy aging?",{"text":117,"@type":113},"Epidemiologic and genetic evidence from the general population and exceptional longevity cohorts points to attenuated GH/IGF-1 signaling as a mediator of healthy aging.",{"name":119,"@type":110,"acceptedAnswer":120},"What therapeutic strategy is being explored based on this evidence?",{"text":121,"@type":113},"Preclinical trials are testing newly developed and repurposed therapeutics that diminish GH/IGF-1 signaling, with the potential to delay aging and age-related diseases.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},424717,1790779757,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81,"preview_page_count":4},3985747858866,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Innovation in Aging, 2025, Vol. 9, No. S2 327  \nAbstract citation ID: igaf122.1103  \nGH/IGF-1 AXIS AS A GEROTHERAPEUTIC TARGET  \nSofiya Milman, Albert Einstein College of Medicine, Albert Einstein College of Medicine, New York, United States  \nWhile growth hormone/ insulin like growth factor-1 (GH/ IGF-1) is a well-documented modulator of aging and longevity in model organisms, its role in human aging is less established.  \nGrowing epidemiologic and genetic evidence from general population and exceptional longevity cohorts is pointing to attenuated GH/IGF-1 signaling as a mediator of healthy aging and protection against age-related diseases, including cancer, diabetes, dementia, and cardiovascular disease. This evidence has led to preclinical trials of newly developed and repurposed therapeutics that diminish GH/IGF-1 signaling, with the potential to delay aging and age-related diseases in people.","cbCaiaKGxQmEOKTP","https://ap.wps.com/l/cbCaiaKGxQmEOKTP","pdf",335193,"English","# Background\n# Evidence from human cohorts\n## Healthy aging and disease protection\n# Therapeutic implications\n## Preclinical trials targeting GH/IGF-1","[{\"question\":\"How is GH/IGF-1 linked to aging in model organisms versus humans?\",\"answer\":\"In model organisms, GH/IGF-1 is well established as a modulator of aging and longevity. In humans, its role in aging is described as less established.\"},{\"question\":\"What evidence suggests attenuated GH/IGF-1 signaling may promote healthy aging?\",\"answer\":\"Epidemiologic and genetic evidence from the general population and exceptional longevity cohorts points to attenuated GH/IGF-1 signaling as a mediator of healthy aging.\"},{\"question\":\"What therapeutic strategy is being explored based on this evidence?\",\"answer\":\"Preclinical trials are testing newly developed and repurposed therapeutics that diminish GH/IGF-1 signaling, with the potential to delay aging and age-related diseases.\"}]","GH/IGF-1 Axis as a Gerotherapeutic Target - Abstract citation ID igaf122.1103 | PDF",1790635161]