[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-216931-en":3,"doc-seo-216931-105":30,"detail-sidebar-cat-0-en-105":92},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"site_id":24,"html_lang":23,"table_of_contents":25,"faqs":26,"seo_title":27,"seo_description":14,"update_tm":28,"read_time":29},216931,137451207643,"Margaret","https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2",7,"Healthcare","Gentamicin Sulfate Injection, USP - 80 mg/2 mL","Gentamicin Sulfate Injection, USP (80 mg/2 mL; 40 mg/mL as gentamicin) is an aminoglycoside indicated to treat or prevent infections proven or strongly suspected to be bacterial. The label emphasizes careful clinical monitoring due to aminoglycoside-associated toxicity, including potential nephrotoxicity and irreversible ototoxicity. Renal function, urinary findings, and periodic blood tests guide dose adjustment, while serum peak/trough monitoring helps maintain safe levels and avoid toxic concentrations.","Gentamicin Sulfate  \nInjection, USP  \n80 mg/2 mL  \n(40 mg/mL as Gentamicin)  \nFOR INTRAVENOUS INFUSION OR INTRAMUSCULAR INJECTION CAUTION: MUST BE DILUTED FOR INTRAVENOUS USE.  \nFliptop Vial  \nRx only  \nTo reduce the development of drug-resistant bacteria and maintain the effectiveness of gentamicin and other antibacterial drugs, gentamicin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.  \nWARNINGS  \nPatients treated with aminoglycosides should be under close clinical observation because of the potential toxicity associated with their use.  \nAs with other aminoglycosides, Gentamicin Sulfate Injection, USP is potentially nephrotoxic. The risk of nephrotoxicity is greater in patients with impaired renal function and in those who receive high dosage or prolonged therapy.  \nNeurotoxicity manifested by ototoxicity, both vestibular and auditory, can occur in patients treated with Gentamicin Sulfate Injection, USP, primarily in those with pre-existing renal damage and in patients with normal renal function treated with higher doses and/or for longer periods than recommended. Aminoglycoside-induced ototoxicity is usually irreversible. Other manifestations of neurotoxicity may include numbness, skin tingling, muscle twitching and convulsions.  \nRenal and eighth cranial nerve function should be closely monitored, especially in patients with known or suspected reduced renal function at onset of therapy and also in those whose renal function is initially normal but who develop signs of renal dysfunction during therapy. Urine should be examined for decreased specific gravity, increased excretion of protein, and the presence of cells or casts. Blood urea nitrogen, serum creatinine, or creatinine clearance should be determined periodically. When feasible, it is recommended that serial audiograms be obtained in patients old enough to be tested, particularly high-risk patients. Evidence of ototoxicity (dizziness, vertigo, tinnitus, roaring in the ears or hearing loss) ornephrotoxicity requires dosage adjustment or discontinuance of the drug. As with the other aminoglycosides, on rare occasions changes in renal and eighth cranial nerve function may not become manifest until soon after completion of therapy.  \nSerum concentrations of aminoglycosides should be monitored when feasible to assure adequate levels and to avoid potentially toxic levels. When monitoring gentamicin peak concentrations, dosage should be adjusted so that prolonged levels above 12 mcg/mL are avoided. When monitoring gentamicin trough concentrations, dosage should be adjusted so that levels above 2 mcg/mL are avoided. Excessive peak and/or trough serum concentrations of aminoglycosides may increase the risk of renal and eighth cranial nerve toxicity. In the event of overdose or toxic reactions, hemodialysis may aid in the removal of  \ngentamicin from the blood, especially if renal function is, or becomes, compromised. The rate of removal of gentamicin is considerably lower by peritoneal dialysis than it is by hemodialysis.  \nConcurrent and/or sequential systemic or topical use of other potentially neurotoxic and/or nephrotoxic drugs, such as cisplatin, cephaloridine, kanamycin, amikacin, neomycin, polymyxin B, colistin, paromomycin, streptomycin, tobramycin, vancomycin, and viomycin, should be avoided.  \nOther factors which may increase patient risk to toxicity are advanced age and dehydration.  \nThe concurrent use of gentamicin with potent diuretics, such as ethacrynic acid or furosemide, should be avoided, since certain diuretics by themselves may cause ototoxicity. In addition, when administered intravenously, diuretics may enhance aminoglycoside toxicity by altering the antibiotic concentration in serum and tissue.  \nAminoglycosides can cause fetal harm when administered to a pregnant woman (see WARNINGS  \nsection) .   \nDESCRIPTION  \nGentamicin Sulfate Injection, USP is a sterile, nonpyrogenic solution of","cbCaio6jKpdhm8Gs","https://ap.wps.com/l/cbCaio6jKpdhm8Gs","pdf",182528,1,12,"English","en",105,"# WARNINGS\n## Nephrotoxicity and neurotoxicity\n## Monitoring and dose adjustment\n# DESCRIPTION\n## Composition and classification\n# CLINICAL PHARMACOLOGY\n## Pharmacokinetics after administration","[{\"question\":\"What infections is gentamicin intended to treat or prevent?\",\"answer\":\"Gentamicin should be used only to treat or prevent infections proven or strongly suspected to be caused by bacteria.\"},{\"question\":\"Why is close clinical monitoring required during gentamicin therapy?\",\"answer\":\"Because aminoglycosides can cause toxicity, including potential nephrotoxicity and neurotoxicity such as vestibular and auditory ototoxicity.\"},{\"question\":\"How should serum gentamicin peak and trough levels be managed?\",\"answer\":\"Adjust dosage to avoid prolonged peak levels above 12 mcg/mL and trough levels above 2 mcg/mL, since excessive levels increase the risk of renal and eighth cranial nerve toxicity.\"}]","Gentamicin Sulfate Injection, USP - 80 mg/2 mL | PDF",1788828404,30,{"code":4,"msg":31,"data":32},"ok",{"site_id":24,"language":23,"slug":33,"title":13,"keywords":34,"description":14,"schema_data":35,"social_meta":87,"head_meta":89,"extra_data":91,"updated_unix":28},"gentamicin-sulfate-injection-usp-80-mg2-ml","",{"@graph":36,"@context":86},[37,54,69],{"@type":38,"itemListElement":39},"BreadcrumbList",[40,44,48,51],{"item":41,"name":42,"@type":43,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":45,"name":46,"@type":43,"position":47},"https://docshare.wps.com/document/","Document",2,{"item":49,"name":12,"@type":43,"position":50},"https://docshare.wps.com/document/healthcare/",3,{"item":52,"name":13,"@type":43,"position":53},"https://docshare.wps.com/document/gentamicin-sulfate-injection-usp-80-mg2-ml/216931/",4,{"url":52,"name":13,"@type":55,"author":56,"headline":13,"publisher":58,"fileFormat":61,"inLanguage":23,"description":14,"dateModified":62,"datePublished":63,"encodingFormat":61,"isAccessibleForFree":64,"interactionStatistic":65},"DigitalDocument",{"name":9,"@type":57},"Person",{"url":41,"name":59,"@type":60},"DocShare","Organization","application/pdf","2026-09-11","2026-09-08",true,{"@type":66,"interactionType":67,"userInteractionCount":20},"InteractionCounter",{"@type":68},"ViewAction",{"@type":70,"mainEntity":71},"FAQPage",[72,78,82],{"name":73,"@type":74,"acceptedAnswer":75},"What infections is gentamicin intended to treat or prevent?","Question",{"text":76,"@type":77},"Gentamicin should be used only to treat or prevent infections proven or strongly suspected to be caused by bacteria.","Answer",{"name":79,"@type":74,"acceptedAnswer":80},"Why is close clinical monitoring required during gentamicin therapy?",{"text":81,"@type":77},"Because aminoglycosides can cause toxicity, including potential nephrotoxicity and neurotoxicity such as vestibular and auditory ototoxicity.",{"name":83,"@type":74,"acceptedAnswer":84},"How should serum gentamicin peak and trough levels be managed?",{"text":85,"@type":77},"Adjust dosage to avoid prolonged peak levels above 12 mcg/mL and trough levels above 2 mcg/mL, since excessive levels increase the risk of renal and eighth cranial nerve toxicity.","https://schema.org",{"og:url":52,"og:type":88,"og:title":13,"og:site_name":59,"og:description":14},"article",{"robots":90,"canonical":52},"index,follow",{"doc_id":7,"site_id":24},{"code":4,"msg":5,"data":93},[94,98,102,106,111,116,119,123,128,131,135],{"id":20,"doc_module":4,"doc_module_name":46,"category_name":95,"show_sort_weight":96,"slug":97},"Story & Novel",90,"story-novel",{"id":47,"doc_module":4,"doc_module_name":46,"category_name":99,"show_sort_weight":100,"slug":101},"Literature",80,"literature",{"id":53,"doc_module":4,"doc_module_name":46,"category_name":103,"show_sort_weight":104,"slug":105},"Exam",70,"exam",{"id":107,"doc_module":4,"doc_module_name":46,"category_name":108,"show_sort_weight":109,"slug":110},5,"Comic",60,"comic",{"id":112,"doc_module":4,"doc_module_name":46,"category_name":113,"show_sort_weight":114,"slug":115},6,"Technology",50,"technology",{"id":11,"doc_module":4,"doc_module_name":46,"category_name":12,"show_sort_weight":117,"slug":118},40,"healthcare",{"id":120,"doc_module":4,"doc_module_name":46,"category_name":121,"show_sort_weight":29,"slug":122},8,"Research & Report","research-report",{"id":124,"doc_module":4,"doc_module_name":46,"category_name":125,"show_sort_weight":126,"slug":127},9,"Religion & Spirituality",20,"religion-spirituality",{"id":126,"doc_module":4,"doc_module_name":46,"category_name":129,"show_sort_weight":126,"slug":130},"World Cup","world-cup",{"id":132,"doc_module":4,"doc_module_name":46,"category_name":133,"show_sort_weight":132,"slug":134},10,"Lifestyle","lifestyle",{"id":136,"doc_module":4,"doc_module_name":46,"category_name":137,"show_sort_weight":107,"slug":138},19,"General","general"]