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HPV16/18 are enriched in cervical carcinomas, and a subset of NENs shows HPV-associated aggressiveness and distinct molecular patterns.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/genomic-and-transcriptomic-differences-between-neuroendocrine-neoplasms-and-carcinomas-with-human-papillomavirus-hpv-research-open-access/349312/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/genomic-and-transcriptomic-differences-between-neuroendocrine-neoplasms-and-carcinomas-with-human-papillomavirus-hpv-research-open-access/349312.png","ImageObject",300,407,{"name":42,"@type":43},"Mimi","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-09-26","2026-09-22",true,{"@type":52,"interactionType":53,"userInteractionCount":26},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"What is the study’s main objective?","Question",{"text":62,"@type":63},"To compare HPV-positive NENs with HPV-positive non-NENs across anatomical sites using genomic and transcriptomic profiling, aiming to uncover biologically and clinically actionable differences.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"How were HPV16 and HPV18 positive tumors identified?",{"text":67,"@type":63},"HPV16- and HPV18-positive tumors were identified from 101,343 solid tumors profiled with DNA and RNA sequencing at Caris Life Sciences.",{"name":69,"@type":60,"acceptedAnswer":70},"What key molecular feature distinguishes HPV-positive NENs?",{"text":71,"@type":63},"Interferon signaling is significantly suppressed in HPV-positive NENs, suggesting a distinct tumor-immune microenvironment compared with HPV-positive non-NENs.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},349312,1790383953,{"code":4,"msg":81,"data":82},"success",[83,87,91,95,100,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":84,"show_sort_weight":85,"slug":86},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":88,"show_sort_weight":89,"slug":90},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":92,"show_sort_weight":93,"slug":94},"Exam",70,"exam",{"id":96,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},5,"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":96,"slug":129},19,"General","general",{"code":4,"msg":81,"data":131},{"doc_id":78,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":26,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":111,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":117},2336477974920,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Madill et al. Infectious Agents and Cancer (2026) 21:49 Infectious Agents and Cancer  \n[https://doi.org/10.1186/s13027-026-00761-8](https://doi.org/10.1186/s13027-026-00761-8)  \nRESEARCH Open Access  \nGenomic and transcriptomic differences between neuroendocrine neoplasms and carcinomas with human papillomavirus (HPV)  \nMorgann Madill 1†, Udhayvir Grewal2†, Harris Krause3, Andrew Elliott3, Marya Wahidi4, Janet S. Rader6, DeannaTeoh1, Soo J. Park7, John Wallbillich8, David J. Benjamin9, Arash Rezazadeh Kalebasty10, Penelope Duerksen-Hughes11, Robert Morris8, Radhika Gogoi8, Fadi Zaiem12, Thomas J. Herzog 13, Premal H. Thaker 14, Dave Bryant3,  \nMatthew Oberley3, Heloisa Soares15, Joanne Xiu3, Andrew Hinton3, Deepti Jain4, Britt K. Erickson 1, Martina Bazzaro 1,16, Emil Lou 1 and Rouba Ali Fehmi5*  \nAbstract  \nIntroduction Human papillomavirus (HPV) is a well-established oncogenic virus implicated in the development of several epithelial cancers, most notably cervical, anogenital, and oropharyngeal carcinomas. In contrast, neuroendocrine neoplasms (NENs)—a heterogeneous group of malignancies arising from neuroendocrine cells across various organ systems—have not traditionally been linked to HPV infection. In this study, we performed extensive genomic and transcriptomic profiling to compare HPV-positive NENs to HPV-positive non-NENs across anatomical sites, aiming to uncover biologically and clinically actionable differences.  \nMethods HPV16-and HPV18-positive tumors were identified from 101,343 solid tumors profiled at Caris Life Sciences (Phoenix, AZ) with DNA and RNA sequencing. Prevalence of pathogenic mutations and copy number amplifications were calculated. Fisher’s exact/χ2 tests were applied appropriately with p-values adjusted for multiple comparisons (p \u003C 0. 05) .  \nResults HPV positivity was most frequent in cervical carcinomas (70%, 1200/1716) . Importantly, 6%(96/1620) of NENs from all tissues were positive for HPV16 or HPV18 . Among HPV-positive NENs, 93% were high-grade compared to 54% observed in HPV-negative NENs (p \u003C 0. 001), highlighting a strong association between HPV and tumor aggressiveness in this subset. Analysis of HPV-associated sites (cervix, anorectal region, and head and neck) revealed that HPV-positive NENs possess distinct genomic and transcriptomic landscapes compared to HPV-positive non-NENs.  \n†Morgann Madill and Udhayvir Grewal contributed equally to this work.  \n*Correspondence:  \nRouba Ali Fehmi[alifehmi@med.umich.edu](alifehmi@med.umich.edu)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2026. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creati](http://creati)[vecommons.org/licenses/by-nc-nd/4.0/](vecommons.org/licenses/by-nc-nd/4.0/.)[.](vecommons.org/licenses/by-nc-nd/4.0/.)  \nMadill et al. Infectious Agents and Cancer (2026) 21:49 Page 2 of 8  \nNotably, interferon signaling was significantly suppressed in HPV-positive NENs, suggesting a unique tumor-immune microenvironment.  \nConclusions Our findings indicate that HPV-positive N","cbCaimjcFGJtu3Ps","https://ap.wps.com/l/cbCaimjcFGJtu3Ps","pdf",2124390,"English","# Abstract\n# Introduction\n## HPV and cancer epidemiology\n## WHO classification of neuroendocrine neoplasms\n# Methods\n# Results\n## Prevalence across tumor sites\n## HPV-associated aggressiveness\n## Distinct genomic and transcriptomic landscapes\n# Conclusions","[{\"question\":\"What is the study’s main objective?\",\"answer\":\"To compare HPV-positive NENs with HPV-positive non-NENs across anatomical sites using genomic and transcriptomic profiling, aiming to uncover biologically and clinically actionable differences.\"},{\"question\":\"How were HPV16 and HPV18 positive tumors identified?\",\"answer\":\"HPV16- and HPV18-positive tumors were identified from 101,343 solid tumors profiled with DNA and RNA sequencing at Caris Life Sciences.\"},{\"question\":\"What key molecular feature distinguishes HPV-positive NENs?\",\"answer\":\"Interferon signaling is significantly suppressed in HPV-positive NENs, suggesting a distinct tumor-immune microenvironment compared with HPV-positive non-NENs.\"}]","Genomic and transcriptomic differences between neuroendocrine neoplasms and carcinomas with human papillomavirus (HPV) - research open access | PDF",1790082703]